8 Optimal Nootropics to Help Neurogenesis (BDNF) as of 2024

Updated on March 15, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Overview of the best nootropics for enhancing neurogenesis and BDNF activity.

Are you looking for ways to boost your neurogenesis?

Are you curious about how nootropics can help improve your BDNF?

If so, you’ve come to the right place.

In this article, we’ll be discussing some of the best nootropics for neurogenesis and BDNF.

Best Nootropics for Neurogenesis

1. Nooceptin

Nooceptin helps to increase neurogenesis by stimulating the production of neurotrophic factors (NTFs). This is done by providing the necessary nutrients and extracts, such as citicoline, rhodiola rosea, bacopa monnieri, L-theanine, ginkgo biloba, lion’s mane and panax ginseng.

These compounds help to increase the production of NTFs, which in turn help to stimulate the growth and development of new neurons in the brain. As a result, Nooceptin helps to improve cognitive function, memory retention and recall, focus, and overall brain health.

2. Lion’s Mane Mushroom

Lion’s mane mushroom is one of the most powerful nootropics for neurogenesis. It has been used for centuries to help improve cognitive function(1), as well as boost nerve growth factor levels. Studies have found that Lion’s mane mushroom can stimulate the growth of new neurons and increase the number of stem cells in the brain.

It has also been found to help reduce symptoms of depression, anxiety, and fatigue. Additionally, it has been found to improve memory and focus. Taking Lion’s mane mushroom as a nootropic can help increase neurogenesis and improve overall cognitive function.

3. Bacopa Monnieri

Bacopa Monnieri is another popular nootropic that can help with neurogenesis(2). This herb is traditionally used in Ayurvedic medicine and is known for its neuroprotective and neuroregenerative properties. It is believed to increase neurogenesis by boosting levels of NGF and BDNF, two important proteins that help create new neurons.

It may also help to improve learning and memory, enhance focus and concentration, and reduce stress and anxiety. The active ingredient in Bacopa Monnieri is bacoside A, which is thought to be responsible for its neurogenesis-promoting effects.

4. DHA (Omega-3)

DHA (Omega-3) is an essential fatty acid that is needed for proper brain functioning. Studies indicate that it can be beneficial in increasing neurogenesis, as it is believed to promote the growth of new neurons in the hippocampus(3). This is thought to be due to its ability to protect against oxidative stress, which is a major contributor to the decline of cognitive abilities.

Additionally, it may also help improve memory, focus, and learning abilities. Supplementing with DHA (Omega-3) can be a great way to help increase neurogenesis and improve overall brain health.

5. Panax Ginseng

Panax ginseng is an adaptogenic herb that has been used for centuries in traditional Chinese medicine. It is known to have a positive effect on cognitive functioning, and it also has powerful neuroprotective properties. Studies have shown that Panax ginseng can help to increase the production of nerve growth factor (NGF)(4), which is essential for the growth and maintenance of neurons in the brain.

This means that taking Panax ginseng can help to promote neurogenesis and help to improve cognitive functioning. Furthermore, it has also been shown to reduce inflammation in the brain, which is important for protecting the neurons from damage. As such, Panax ginseng is an excellent choice for those looking to increase their neurogenesis.

6. L-Theanine

L-theanine is an amino acid found naturally in green tea and other plants. It has been used as a nootropic for years, and has been found to help promote neurogenesis. Studies have shown that L-theanine can increase the production of nerve growth factors(5), which in turn helps to promote the growth of new neurons.

It is also known to improve the performance of existing neurons, and is believed to help protect against neurodegenerative diseases. Additionally, L-theanine has been found to reduce stress and anxiety, making it a great choice for those looking to increase neurogenesis naturally.

7. Ashwagandha

Ashwagandha is an incredibly powerful nootropic that has been used for centuries in the Ayurvedic system of medicine. It is known to be a potent neuroregenerative agent, enhancing neurogenesis and promoting the growth of new neurons(6). This makes it an ideal nootropic for those looking to increase their cognitive abilities and improve their overall brain health.

Ashwagandha has also been shown to have neuroprotective benefits and may even help protect the brain from age-related cognitive decline. It is believed to help improve memory and focus, as well as reduce stress and anxiety. For those looking for a nootropic to increase neurogenesis, Ashwagandha is an excellent choice.

8. Noopept

Noopept is considered one of the most powerful nootropics for neurogenesis. It is known to increase the production of nerve growth factors, which help stimulate the growth of new neurons in the brain(7). Studies have also shown that Noopept can improve memory and executive functioning.

Additionally, it has been found to reduce anxiety and improve the overall mood of the user. The effects of Noopept on the body can be felt almost immediately, and it is considered one of the most powerful nootropics for neurogenesis.

How We Picked the Top Nootropics for Neurogenesis

We employed a multi-faceted evaluation approach to find the best nootropics for neurogenesis. We scrutinized effectiveness, ingredients, brand reputation, transparency, manufacturing techniques, user feedback, price, and value. We examined these factors to present our readers with a comprehensive and trustworthy list of top neurogenesis-boosting nootropics.


We analyzed clinical research and user experiences to measure neurogenesis enhancement, focusing on neural stem cell proliferation, nerve growth, and synaptic plasticity.


We evaluated each formula, prioritizing evidence-based, natural, and high-quality ingredients that boost neurogenesis and support brain health.

Scientific Evidence

We consulted peer-reviewed studies and meta-analyses to confirm the efficiency of key ingredients in promoting neurogenesis.


We reviewed optimal dosages and ingredient proportions, ensuring they conformed to established research for maximum impact.


We ensured the safety of each ingredient, considering potential side effects and interactions, and confirming compliance with regulatory guidelines. FDA-approved components are given priority.

Brand Reputation

We assessed brands’ credibility and trustworthiness through customer testimonials, expert endorsements, and company background.

Product Transparency

We valued comprehensive ingredient disclosure, including sources and concentrations, to support informed consumer decision-making.

Manufacturing Process

We inspected manufacturing standards, giving preference to products produced in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, emphasizing testimonies that detail neurogenesis enhancement and improved brain health.


We compared product prices, ensuring they were competitive and correlated with the quality and effectiveness of the nootropic.


We assessed overall value, considering the balance of price, quality, and effectiveness to guarantee optimal return on investment.

How Can Nootropics Help with Neurogenesis?

Nootropics are substances that are widely known to have cognitive-enhancing effects. They have been used for centuries to improve mental alertness and focus. More recently, they have also been studied for their potential to improve brain health and increase neurogenesis. Neurogenesis is the process of creating new neurons in the brain, which can lead to increased cognitive performance and improved brain function. Nootropics have been found to have beneficial effects on this process, helping to promote the production of new neurons in the brain.

Nootropics work by increasing the levels of neurotransmitters in the brain, such as dopamine and serotonin. These neurotransmitters are important for learning, memory and mood regulation. Additionally, nootropics can also increase the production of neurotrophic factors, which are proteins that help support the growth and survival of neurons in the brain. By increasing the levels of these neurotransmitters and neurotrophic factors, nootropics can help stimulate the growth of new neurons in the brain, leading to improved cognitive performance.

Nootropics can also improve the brain’s energy metabolism, leading to better overall brain health. They can also help protect the brain from oxidative stress and inflammation, which can cause damage to neurons and lead to cognitive decline. By improving the brain’s energy metabolism and protecting it from oxidative stress and inflammation, nootropics can help support a healthy brain and increase neurogenesis.

What are the Benefits of Nootropics for Neurogenesis?

Nootropics are believed to help with neurogenesis by increasing the number of neurons and strengthening the connections between them. This helps with memory formation, recall, and overall cognitive performance. Nootropics can also help with the production of neurotransmitters, which are essential for healthy brain function. Additionally, some nootropics have been found to increase levels of BDNF (Brain-Derived Neurotrophic Factor), which is a key hormone responsible for neurogenesis.

The benefits of nootropics for neurogenesis include increased cognitive performance, improved memory recall, better focus, and improved mental clarity. Nootropics are also believed to help protect the brain from damage caused by free radicals, and may even help reduce the risk of age-related cognitive decline. Nootropics can also help reduce stress and anxiety, as well as improve mood and motivation.

The Safety and Side Effects of Taking Nootropics for Neurogenesis

When considering taking nootropics to increase neurogenesis, it is important to weigh the potential benefits against the associated risks and side effects. Nootropics are generally considered safe when taken responsibly and in moderation, but they can still have some side effects. This is especially true when taking a combination of nootropics, as this can increase the risk of potential side effects.

Common side effects associated with taking nootropics for neurogenesis include headaches, fatigue, nausea, and digestive issues. It is important to ensure that you are aware of the potential risks and side effects of any nootropics that you decide to take, and to talk to a doctor before starting any new supplement regimen. Additionally, it is important to be aware of any potential drug interactions that may occur when taking multiple nootropics, and to make sure that your doctor is aware of all of the supplements that you are taking.

Tips on Choosing the Right Nootropic for Increasing Neurogenesis

When it comes to choosing the right nootropic for increasing neurogenesis, it’s important to keep in mind your individual needs and goals. While some nootropics may be more effective than others, it’s important to consider the safety, side effects, and potential interactions with other medications. Research each nootropic carefully and consult with your doctor before taking any supplement. Additionally, you can look for clinically-studied, natural nootropics that are backed by research and have a track record of safety and efficacy.

Conclusion: The Pros and Cons of Taking Nootropics for Neurogenesis & BDNF

Nootropics can be a powerful tool to help with neurogenesis, but must be used responsibly. They can provide significant cognitive benefits, but it is important to understand the potential side effects, as well as the potential for addiction. Furthermore, you should always consult with a medical professional before taking any supplement, especially if you have an existing medical condition.

When taken properly, nootropics can be a great way to boost your cognitive function and help with the growth of new neurons. Nootropics can help to improve memory and concentration, as well as increase focus and mental clarity. They can also help to reduce stress, improve mood, and even reduce the symptoms of depression.

Ultimately, nootropics should be used in conjunction with a healthy lifestyle and proper nutrition. This can help to ensure that you get the most out of the supplement and maximize its benefits. With the right combination of nootropics and healthy habits, you can experience the many benefits of neurogenesis and see improved mental clarity and focus.

Sources, Studies, and Scientific Research
  1. Saitsu, Yuusuke et al. “Improvement of cognitive functions by oral intake of Hericium erinaceus.” Biomedical research (Tokyo, Japan) vol. 40,4 (2019): 125-131. doi:10.2220/biomedres.40.125 ↩
  2. Sivasangari, Karunanithi, and Koilmani Emmanuvel Rajan. “Standardized Bacopa monnieri Extract Ameliorates Learning and Memory Impairments through Synaptic Protein, Neurogranin, Pro-and Mature BDNF Signaling, and HPA Axis in Prenatally Stressed Rat Offspring.” Antioxidants (Basel, Switzerland) vol. 9,12 1229. 4 Dec. 2020, doi:10.3390/antiox9121229 ↩
  3. Sun, Grace Y et al. “Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases.” Prostaglandins, leukotrienes, and essential fatty acids vol. 136 (2018): 3-13. doi:10.1016/j.plefa.2017.03.006 ↩
  4. Hou, Wei et al. “Effects of Ginseng on Neurological Disorders.” Frontiers in cellular neuroscience vol. 14 55. 20 Mar. 2020, doi:10.3389/fncel.2020.00055 ↩
  5. Zeng, Li et al. “l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways.” Oxidative medicine and cellular longevity vol. 2021 8850112. 19 Jul. 2021, doi:10.1155/2021/8850112 ↩
  6. Gopukumar, Kumarpillai et al. “Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study.” Evidence-based complementary and alternative medicine : eCAM vol. 2021 8254344. 30 Nov. 2021, doi:10.1155/2021/8254344 ↩
  7. Taghizadeh, Mona et al. “Retraction notice to “Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process” [Heliyon (2021) e06219].” Heliyon vol. 7,5 e06981. 17 May. 2021, doi:10.1016/j.heliyon.2021.e06981 ↩