5 Best Nootropics for Quitting Smoking in 2024 (Erase Nicotine Withdrawal)

Updated on February 6, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
How nootropics support the brain in overcoming nicotine withdrawal for smokers.

What are the best nootropics for reducing nicotine withdrawal when quitting smoking?

Are you struggling to quit smoking? You’re not alone. Nicotine addiction is one of the toughest habits to kick, with high rates of relapse even among those who have made the commitment to quit.

But there is hope. Nootropics, or “smart drugs,” have been found to be incredibly effective in easing the process of nicotine withdrawal, with some even mimicking the bioactivity of nicotine itself.

In this in-depth review, we’ll be looking at the top five nootropics to support smoking cessation, so you can finally say goodbye to this harmful habit for good.

Best Nootropics for Nicotine Withdrawal

How to Choose Best Nootropics for Nicotine Withdrawal?

Selecting the right nootropics for nicotine withdrawal is crucial for managing symptoms and supporting cognitive function during this challenging period.

FactorDescriptionWhy It’s Important
EffectivenessThe ability of a nootropic to alleviate withdrawal symptoms.Ensures the supplement positively impacts your quitting process.
Ingredient ProfileThe quality and type of ingredients used in the nootropic formula.High-quality, natural ingredients are generally safer and may be more effective.
Scientific BackingThe extent of research and studies supporting the nootropic’s benefits.Provides reassurance that the product is likely to be effective.
Side Effect ProfileThe likelihood of experiencing adverse reactions from the nootropic.Minimizes the risk of negative health impacts during withdrawal.
Brand ReputationThe trustworthiness and history of the company producing the nootropic.A reputable brand often ensures product quality and reliability.
  • Effectiveness: The most important factor to consider is how well the nootropic helps with nicotine withdrawal symptoms. Look for nootropics that have a track record of helping others quit smoking, as evidenced by user testimonials and clinical research.
  • Ingredient Profile: The presence of high-quality, natural ingredients is key. Ingredients should have a clear link to easing withdrawal symptoms like anxiety, irritability, and cognitive decline.
  • Scientific Backing: Products supported by scientific research ensure that you’re not just buying into a placebo effect. Peer-reviewed studies that demonstrate a nootropic’s efficacy are a strong indicator of a worthwhile product.
  • Side Effect Profile: Even the most effective nootropic is not ideal if it causes significant side effects. Opt for nootropics known for their safety and low risk of adverse effects.
  • Brand Reputation: A reputable brand with transparent practices and positive reviews can increase confidence in the effectiveness and safety of the nootropic supplement.

The Best Nootropics for Nicotine Withdrawal of 2024

According to our in-depth research and testing, the best nootropics for nicotine withdrawal are:

1. Feedamind

Feedamind is a nootropic supplement that can ease the physical and psychological symptoms associated with nicotine withdrawal. This supplement can also enhance cognitive performance and improve mood while quitting smoking. The formula of Feedamind contains natural ingredients such as Cat’s Claw, a herb used for centuries to treat mood disorders, and Bacopa Monnieri, another herb used to enhance mental performance.(1)(2) Feedamind also includes Marigold Flower Extract, which can alleviate symptoms of fatigue and improve concentration.(3)

Overall, Feedamind is a great nootropic supplement for those looking to quit smoking. It is a natural, safe, and effective way to support your brain health during nicotine withdrawal. Feedamind is also affordable and easy to use, making it a great option for those who are on a budget or always on-the-go. If you are struggling with quitting smoking and experiencing withdrawal symptoms, Feedamind can be an effective tool to help you quit smoking for good.


  • Improves focus and concentration
  • Enhances memory and recall
  • Reduces mental fatigue
  • Improves hand-eye coordination
  • Reduces stress and elevates mood
  • Promotes neuron development and brain health


  • Has suboptimal dosages of some ingredients
  • May cause side effects, such as headaches and drowsiness, in some users

In addition, seeking professional help can also improve your chances of successfully quitting smoking. It is important to remember that quitting smoking is a difficult process, but with the right support and tools, it is possible to overcome nicotine addiction.

2. Mind Lab Pro

Mind Lab Pro is one of the five best nootropics for nicotine withdrawal that can help you achieve mental clarity and focus while trying to quit smoking. Mind Lab Pro is a natural nootropic that is designed to enhance cognitive function, memory, and focus. It contains 11 well-researched ingredients that work together to optimize brain activity and boost mental performance.

Some of the key ingredients in Mind Lab Pro include Bacopa Monnieri, Lion’s Mane Mushroom, and Maritime Pine Bark Extract, among others. These ingredients are known to have cognitive-enhancing effects, such as improving memory retention, reducing anxiety, and increasing mental clarity.(4) Mind Lab Pro is not addictive, and it’s safe to use daily. It’s also vegan, non-GMO, and gluten-free.

This nootropic supplement can be taken by anyone who wants to improve their mental performance, including students, professionals, and athletes. If you’re trying to quit smoking, taking Mind Lab Pro can help you minimize the effects of nicotine withdrawal. It can improve your focus and mood, reduce anxiety, and increase your motivation to quit smoking.


  • Precisely dosed and research-backed nootropics that complement each other
  • Boosts brain energy and improves mental performance
  • Sharpens memory, slows cognitive decline, and promotes a positive-minded outlook


  • Magnitude of effects may be less profound for some people

Overall, Mind Lab Pro is an effective and safe nootropic supplement that can help you achieve optimal brain function and reduce the symptoms of nicotine withdrawal.

3. Rhodiola Rosea

Rhodiola Rosea is a natural herb that has been used in traditional medicine in Europe and Asia for centuries. It is an adaptogenic herb, which means that it helps your body handle stress more effectively. Rhodiola Rosea improves mood and decreases feelings of burnout in both anxious and highly stressed individuals.(5) This herb contains active compounds called salidroside and rosavin, which protect your brain from oxidative stress and improve signaling in your hippocampus, an area of your brain in which memories are processed.

Studies have shown Rhodiola Rosea to reduce mental fatigue and increase feelings of well-being in college students during stressful exam periods. It is often used in nootropic supplements to improve mental performance. Some studies have found that Rhodiola Rosea can improve exercise performance and help with weight loss.


  • Has strong adaptogenic, anti-fatigue, and anti-stress effects
  • Helps improve mood and cognitive function
  • Reduces anxiety and depression symptoms


  •  May take long term use to show results
  •  Some people may experience adverse effects, such as dry mouth, dizziness, or insomnia

Overall, Rhodiola Rosea is a promising natural herb that may have several potential benefits for mental and physical health. More research is needed to fully understand its mechanisms and optimal dosing, but it could be a useful addition to a healthy lifestyle.

4. L-Theanine

L-Theanine, a natural amino acid found in green tea leaves, has been gaining popularity as a nootropic supplement for its benefits to the nervous system. It has been shown to increase alpha brain wave activity, which induces a calm, relaxed state without causing drowsiness. This can help reduce anxiety and stress, which are common symptoms of nicotine withdrawal. Withdrawal from nicotine can cause disruptions in sleep patterns. L-Theanine has been shown to improve the quality of sleep by increasing relaxation and reducing anxiety.(6)

L-Theanine has been shown to improve cognitive function, including attention and memory, without causing drowsiness. This can be particularly helpful during the withdrawal process, which can cause brain fog and difficulty concentrating. It has been shown to increase levels of dopamine, serotonin, and GABA, which are neurotransmitters that play a role in regulating mood. This can help individuals dealing with nicotine withdrawal to feel more positive and motivated.


  • Promotes relaxation, reduces anxiety, and improves sleep quality
  • Improves cognitive performance and attention, without causing drowsiness or impairing motor skills 


  •  May interact with certain medications, such as blood pressure or stimulant drugs

Overall, L-Theanine can be a helpful supplement for those trying to quit smoking. It can reduce anxiety and stress, improve sleep quality, enhance cognitive function, and boost mood.

5. N-Acetyl L-Tyrosine (NALT)

N-Acetyl L-Tyrosine (NALT) is a nootropic that is known for its effectiveness in reducing stress and increasing focus. This amino acid derivative is a more bioavailable form of L-tyrosine, which is required by the body to produce neurotransmitters that regulate mood and stress response.

NALT promotes mental agility and productivity by providing a precursor to neurotransmitters in the brain. It improves cognitive function by increasing alertness, attention, and memory recall. NALT boosts physical performance by reducing muscle fatigue and improving endurance during exercise. It reduces stress and anxiety levels by regulating cortisol secretion and enhancing resilience to stressors.(7) NALT can alleviate symptoms of depression and improve emotional well-being by promoting the production of mood-regulating neurotransmitters.


  • Improves cognitive function and performance under stress
  • Enhances dopamine and norepinephrine levels in the brain, which improve mood, motivation, and attention
  • Has neuroprotective properties, helping protect brain cells from oxidative damage


  • Effectiveness may vary for different users depending on various factors
  • May cause adverse effects, such as nausea, headache, or heartburn in some people

NALT is considered a safe and well-tolerated nootropic, with few reported side effects. However, it is important to note that NALT supplements should be taken in moderation and as directed by a healthcare professional. In some cases, high doses of NALT may lead to nausea, headaches, or gastrointestinal discomfort. Overall, NALT is a promising nootropic that can help individuals reduce nicotine cravings and improve their overall mental and emotional well-being.

How Do Nootropics for Nicotine Withdrawal Work?

Nootropics are cognitive enhancers that can help people manage addiction withdrawals. When it comes to nicotine addiction, nootropics work in different ways to ease the symptoms of withdrawal and promote brain health. Here are some ways that nootropics work for nicotine withdrawal;

  • Substituting bioactivity of nicotine: Some nootropics have chemical structures that are similar to nicotine. These substances may mimic the effects of nicotine, reducing cravings and withdrawal symptoms.
  • Enhancing neurotransmitter levels: Nicotine addiction disrupts the delicate balance of neurotransmitters in the brain. Nootropics such as L-theanine and creatine can facilitate the release of natural neurotransmitters such as dopamine, serotonin, and GABA. This can help the brain re-establish its natural equilibrium and reduce the severity of withdrawal symptoms.
  • Modulating stress: Stress is a common trigger for nicotine cravings. Adaptogenic herbs like Rhodiola Rosea can help the body adapt to stress, reducing the risk of relapse.
  • Protecting brain cells: Nicotine addiction can damage brain cells and promote inflammation. Nootropics with antioxidant and anti-inflammatory properties, such as Bacopa Monnieri, protect brain cells from damage and promote overall brain health.

In short, nootropics for nicotine addiction work by reducing cravings, restoring neurotransmitter balance, reducing stress, and protecting brain cells. By promoting brain health, nootropics can help individuals overcome nicotine addiction and lead a healthier lifestyle.

What to Consider Before Buying Nootropics for Nicotine Withdrawal?

Before you invest in nootropics for nicotine withdrawal, it’s important to evaluate several key aspects to ensure that you make an informed decision.

1. Personal Sensitivities and Allergies

Ensure that you do not have any sensitivities or allergies to the ingredients in the nootropic supplement. Check the label for any potential allergens and consider any past experiences with similar supplements.

2. Interaction With Other Medications

If you are currently taking other medications, it’s crucial to ensure that there won’t be any negative interactions with the nootropic. It’s important to be aware of the ingredients and their potential interactions.

3. Long-Term Usability

Consider whether the nootropic is suitable for long-term use, especially if you anticipate a prolonged withdrawal period. Assess the risk of tolerance and the need for cycling the supplement.

4. Lifestyle Compatibility

Evaluate whether the nootropic fits into your daily routine and lifestyle. Consider factors like ease of use, the convenience of dosing, and the requirement for any dietary changes.

5. Financial Investment

Think about the financial aspect of purchasing nootropics. High-quality supplements can be costly, so weigh the potential benefits against the expense to determine if it’s a viable long-term option.

How We Picked the Top Nootropics for Nicotine Withdrawal

To identify the best nootropics for nicotine withdrawal, we employed a comprehensive review process that considered effectiveness, ingredients, brand reputation, transparency, manufacturing method, user feedback, price, and value. This thorough evaluation allowed us to present a well-researched and trustworthy list of the top nootropics to ease nicotine withdrawal symptoms.


We examined clinical trials and user experiences to evaluate the nootropics’ ability to alleviate withdrawal symptoms, reduce cravings, and promote overall well-being during the cessation process.


We carefully analyzed each formula, focusing on evidence-based, natural, and high-quality ingredients known to mitigate nicotine withdrawal effects and support brain health.

Scientific Evidence

We relied on peer-reviewed studies and meta-analyses to confirm the efficacy of key ingredients in combating nicotine withdrawal symptoms.


We evaluated optimal dosages and ingredient ratios, ensuring they align with established research for maximum effectiveness and safety.


We assessed the safety of each ingredient, considering potential side effects and interactions, and confirming compliance with regulatory guidelines. We prioritized FDA-approved ingredients.

Brand Reputation

We appraised the credibility and trustworthiness of each brand using customer reviews, expert endorsements, and company history.

Product Transparency

We emphasized complete ingredient disclosure, including the sources and concentrations, enabling informed consumer decision-making.

Manufacturing Process

We investigated manufacturing standards, prioritizing products made in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, giving weight to testimonials that detail the alleviation of nicotine withdrawal symptoms and overall satisfaction.


We compared product prices, ensuring they were competitive and reflective of the quality and efficacy of the nootropic.


We evaluated overall value by considering the balance of price, quality, and effectiveness to guarantee the best return on investment for consumers seeking nootropics for nicotine withdrawal.

Nootropics for Nicotine Withdrawal in Summary

Nicotine use among athletes is high and increasing, with consumption patterns including smoking, chewing tobacco, and nicotine replacement therapies. Together with caffeine, nicotine is considered to be the most widely consumed psychoactive substance in the world. Meanwhile, nootropics for nicotine withdrawal work by speeding up information processing in the brain, reducing reaction times, and improving memory.

We have selected five of the best nootropics for nicotine withdrawal, based on their effectiveness and safety, as well as the quality of the scientific studies that support their use. Feedamind, Mind Lab Pro, Rhodiola Rosea, L-Theanine, and N-Acetyl L-Tyrosine (NALT) are all natural supplements that can help those who are struggling to quit smoking or using other forms of nicotine. Some of these nootropics work best when taken in combination with others, while others are more effective on their own.

The precise dosages and timings will depend on your individual circumstances and goals. We encourage you to consult with a qualified healthcare practitioner before starting any new supplementation program. Ultimately, the best way to quit smoking or using nicotine is through a combination of behavioral and lifestyle changes, along with appropriate medical support.

FAQs About Nootropics for Nicotine Withdrawal

Can nootropics be taken alongside nicotine replacement therapy?

Yes, it is safe to take nootropics alongside nicotine replacement therapy, such as nicotine patches or gum. However, it is important to consult with a healthcare professional before combining any supplements or medications.

Are there any side effects associated with nootropics for nicotine withdrawal?

Most nootropics are considered safe when taken in recommended doses. However, some people may experience mild side effects such as headaches, nausea, or stomach upset. It is important to pay attention to how your body reacts to different supplements and adjust your dosage accordingly.

How can I maximize the effectiveness of nootropics during nicotine withdrawal?

To maximize the effectiveness of nootropics during nicotine withdrawal, maintain a healthy lifestyle, practice stress management techniques, and stay physically active. These factors can help support your brain health and the effectiveness of nootropics.

Can I develop a tolerance to such nootropics?

The development of tolerance to nootropics is rare, but it’s essential to use them responsibly and as directed by a healthcare professional. If you notice a decrease in effectiveness, consult your healthcare provider for guidance.

Sources, Studies, and Scientific Research
  1. Erowele, Goldina Ikezuagu, and Abolanle O. Kalejaiye. “Pharmacology and therapeutic uses of cat’s claw.” American journal of health-system pharmacy 66.11 (2009): 992-995. ↩
  2. Aguiar, Sebastian, and Thomas Borowski. “Neuropharmacological review of the nootropic herb Bacopa monnieri.” Rejuvenation research 16.4 (2013): 313-326. ↩
  3. Hadden, W. Leigh, et al. “Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement.” Journal of agricultural and food chemistry 47.10 (1999): 4189-4194. ↩
  4. Rohdewald, P. “A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology.” International journal of clinical pharmacology and therapeutics 40.4 (2002): 158-168. ↩
  5. Panossian, Alexander, G. Wikman, and Jerome Sarris. “Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy.” Phytomedicine 17.7 (2010): 481-493. ↩
  6. Juneja, Lekh Raj, et al. “L-theanine—a unique amino acid of green tea and its relaxation effect in humans.” Trends in Food Science & Technology 10.6-7 (1999): 199-204. ↩
  7. Matsumura, Takashi, et al. “N‐acetyl‐l‐tyrosine is an intrinsic triggering factor of mitohormesis in stressed animals.” EMBO reports 21.5 (2020): e49211. ↩