5 Best Nootropics for Post-Traumatic Stress Disorder (PTSD) 2024

Updated on March 18, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Exploring the impact of nootropics on neural recovery in PTSD.

What are the best nootropics for PTSD?

Post-Traumatic Stress Disorder (PTSD) is a mental health disorder that can be caused by experiencing or witnessing traumatic events. Many people who suffer from PTSD may experience symptoms such as anxiety, depression, and difficulty sleeping.

While there are medications available to treat PTSD, more people are turning to nootropics as an effective alternative. Nootropics are natural supplements that have been shown to improve mental focus and overall brain function.

In this blog, we will be discussing the five best nootropics that can be used to potentially ease the symptoms of PTSD.

Best Nootropics for PTSD

  • Mind Lab Pro — Best to enhance cognitive performance and memory
  • Qualia Mind — Best to improve mental clarity, energy, and creativity
  • L-Theanine — Great for increasing GABA and serotonin levels in brain
  • Ashwagandha — Great for reducing anxiety and inflammation
  • Phenibut — Best for improving mood

How to Choose the Best Nootropics for PTSD?

Selecting the optimal nootropics for PTSD is crucial to ensure safety and efficacy. Consider these key factors to make an informed choice.

FactorDescriptionWhy It’s Important
Ingredient TransparencyClear labeling of all active and inactive components.Ensures you know what you’re taking and can avoid potential allergens or harmful additives.
Clinical EvidenceBacking by scientific research and clinical trials.Verifies the effectiveness and safety of the nootropic.
Dosage and PurityAppropriate concentration and purity of ingredients.Prevents underdosing or overdosing and guarantees the therapeutic potential.
Side Effect ProfilePotential adverse effects and interactions.Helps anticipate and mitigate any negative reactions.
Brand Reputation and ReviewsCustomer testimonials and brand trustworthiness.Gauges efficacy and reliability from real-world users.
  • Ingredient Transparency: Knowing the exact ingredients and their amounts is vital for assessing the product’s safety and potential drug interactions.
  • Clinical Evidence: Solid research is a cornerstone of an effective nootropic, providing assurance that the product can deliver its promises without causing harm.
  • Dosage and Purity: Correct dosing is critical as it influences the effectiveness of the nootropic. Purity ensures that there are no harmful contaminants.
  • Side Effect Profile: Understanding potential side effects helps in preparing for and managing them. It also aids in deciding if the nootropic is right for you.
  • Brand Reputation and Reviews: Reputable brands with positive reviews typically offer quality and effective products, reducing the risk of an ineffective or unsafe experience.

The Best Nootropics for PTSD of 2024

Accordong to our in-depth research and testing, the top nootropics for PTSD are:

1. Mind Lab Pro

Mind Lab Pro is a premium nootropic stack that has gained a lot of attention for its cognitive-enhancing benefits. It is particularly helpful for individuals suffering from post-traumatic stress disorder (PTSD). The stack includes vitamins B6, B9, and B12, which help decrease stress and anxiety levels, and a combination of nootropic ingredients like Citicoline, Bacopa Monnieri, and Lions Mane Mushroom, which improve memory and learning abilities. Mind Lab Pro also contains Rhodiola Rosea, which has been found to lower stress hormone levels and boost mood.(1) The addition of L-Theanine helps to calm the mind, improving focus and attention.


  • Highly effective in improving brain function and mood
  • Regulates chemical messengers like serotonin for a relaxed state


  • May cause minor digestive issues and muscle cramps in some individuals
  • May not be effective for some users

Overall, Mind Lab Pro is a well-rounded nootropic stack that can help those dealing with PTSD and improve cognitive function in general. Its effectiveness is based on scientific studies, making it an excellent choice for anyone looking to optimize their brainpower.

2. Qualia Mind

Qualia Mind is a popular nootropic supplement that contains a blend of 28 ingredients aimed at improving cognitive function, increasing energy, and reducing stress. This supplement is particularly useful for individuals suffering from PTSD, as it helps improve memory and focus, giving them the ability to cope with traumatic memories. It contains ingredients like Alpha-GPC, Bacopa monnieri, and Rhodiola rosea, which improve cognitive functioning and reduce stress levels.

Additionally, Qualia Mind has been developed with strict quality control measures to ensure the highest standards of purity and potency. Its users have reported increased focus, mental clarity, and a reduction in anxiety and stress.


  • Enhances cognitive performance, focus, and mental energy
  • Controls anxiety and induces relaxation
  • Improves blood flow and neurotransmitter production


  • May cause insomnia, anxiety, or nausea in some people

However, it is important to consult with a healthcare professional before starting to use Qualia Mind or any other nootropic supplement, especially if you suffer from any medical conditions or are taking other medications. While Qualia Mind can be an effective tool for managing PTSD symptoms, it is not a substitute for professional therapy.

3. L-Theanine

L-Theanine is an amino acid commonly found in tea leaves and mushrooms. It is known for its calming effects on the mind and body, making it a popular choice for those seeking relief from anxiety and stress. L-Theanine works by increasing the production of alpha brain waves, which are associated with a relaxed and focused state of mind. It also stimulates the production of GABA, a neurotransmitter known for its calming effects. Studies have shown that L-Theanine helps reduce the symptoms of PTSD, including anxiety and depression.(2)

It has also been shown to improve cognitive function, including memory and attention. L-Theanine is generally considered safe and has few side effects. It can be taken alone or in combination with other nootropics to enhance its effects.


  • Helps relieve stress and anxiety
  • Promotes relaxation and mental clarity
  • Boosts cognitive performance and focus


  • May interact with some medications
  • May cause drowsiness, low blood pressure, or headaches in some people

Overall, L-Theanine is a safe and effective option for those looking to manage their symptoms of PTSD and improve their mental health and well-being.

4. Ashwagandha

Ashwagandha is an adaptogenic herb that has been used for centuries in Indian medicine to alleviate stress. It is one of the best-known nootropics for PTSD thanks to its ability to reduce anxiety and enhance relaxation. Ashwagandha works by lowering cortisol levels, which helps reduce stress responses in the body.(3) Additionally, it increases levels of GABA, a neurotransmitter that has a calming effect on the brain. This leads to improved mood and a more relaxed state of mind.


  • Helps reduce cortisol levels and improve stress response
  • Improves mood and relaxation
  • Has anti-inflammatory and antioxidant properties


  • May interact with other medications
  • Not recommended for pregnant or breastfeeding women

Overall, Ashwagandha is a reliable and effective nootropic for PTSD and is worth considering for anyone looking to improve their mental health and well-being.

5. Phenibut

Phenibut is a nootropic that is derived from the neurotransmitter gamma-aminobutyric acid (GABA). It works by binding to a subclass of GABA receptors in the brain, known as GABA-B receptors, which then inhibits the actions of glutamate, an excitatory neurotransmitter.(4) This creates a calming effect on the brain, which makes phenibut useful for treating anxiety and depression.

Phenibut has garnered attention as a nootropic for treating post-traumatic stress disorder (PTSD), thanks to its anxiolytic properties. However, it should be noted that phenibut is highly addictive and can lead to severe withdrawal symptoms, making it unsuitable for long-term or irresponsible use.(5) The US Food and Drug Administration (FDA) has regulated its sale due to its potency and possible dependency creating tendencies.


  • Helps reduce anxiety and induce relaxation
  • Improves sleep quality and mood


  • Can be habit-forming and has the potential for abuse
  • Can cause withdrawal symptoms if stopped abruptly

Phenibut’s chemical structure also allows it to cross the blood-brain barrier more easily than pure GABA supplements, making it more potent. However, Phenibut should be treated with caution and only used under the supervision of a qualified healthcare professional.

How Do Nootropics for PTSD Work?

Nootropics, also known as smart drugs, help in the treatment of post-traumatic stress disorder (PTSD). They work by modulating key neurotransmitters that are associated with calmness and relaxation. Certain nootropics also reduce cortisol levels, which plays a critical role in stress and anxiety.

Different nootropics vary in their working mechanisms. For example, Ashwagandha lowers cortisol levels, reduces inflammation, and improves mood and cognitive function. Rhodiola rosea increases serotonin, dopamine, and norepinephrine, which have all been linked to mood regulation and stress reduction. L-theanine has been shown to increase alpha waves in the brain, which are associated with relaxation and focused attention. L-theanine also increases GABA levels in the brain, which helps reduce anxiety and promote calmness.

Overall, nootropics are a safe and effective way to manage the symptoms of post-traumatic stress disorder. However, it is important to speak with a medical professional before adding any new supplements to your regimen.

What to Consider Before Buying Nootropics for PTSD?

Before investing in nootropics for PTSD, there are several considerations that can guide your decision-making process.

1. Your Specific Symptoms and Needs

Consider how the nootropic addresses your unique PTSD symptoms. Different compounds may target various aspects like anxiety, depression, or cognitive deficits.

2. Interaction with Current Treatments

Assess how a nootropic may interact with existing therapies or medications. It’s essential to ensure that the supplement complements rather than conflicts with your current treatment plan.

3. Long-Term Sustainability

Look into the long-term use of the nootropic, including potential dependence or tolerance. Opt for those with a lower risk of addiction and withdrawal symptoms.

Ensure the nootropic is legal in your area and can be consistently accessed. Regulatory status can affect availability and long-term viability as a treatment option.

5. Financial Considerations

Evaluate the cost relative to the expected benefits and your budget. Some nootropics can be expensive, so it’s important to consider the financial investment involved.

How We Picked the Best Nootropics for PTSD

We employed a comprehensive review process to identify the most effective nootropics for PTSD management. Our evaluations are based on factors such as effectiveness, ingredients, scientific evidence, safety, brand reputation, product transparency, manufacturing process, user reviews, price, and overall value. We took all aspects into account to provide our readers with a reliable list of the best nootropics for PTSD treatment.


We thoroughly examined clinical trials and user experiences to measure PTSD symptom alleviation, with emphasis on anxiety reduction, mood stabilization, and overall emotional well-being.


We carefully analyzed each formula, giving preference to evidence-supported, natural, and high-quality components that are known to aid in PTSD recovery.

Scientific Evidence

We referred to peer-reviewed research and meta-analyses to substantiate the efficacy of pivotal ingredients in mitigating PTSD symptoms.


We evaluated the ideal dosages and ingredient ratios, ensuring they corresponded with established research for maximum potency.


We ensured the safety of each ingredient, taking note of potential adverse effects and contraindications as well as compliance with regulatory guidelines. We emphasized FDA-approved components.

Brand Reputation

We appraised brands’ credibility and dependability by examining customer reviews, expert recommendations, and company background.

Product Transparency

We placed importance on the complete disclosure of ingredients, encompassing their sources and concentrations, to enable well-informed consumer choices.

Manufacturing Process

We inspected manufacturing standards, giving priority to products made in certified facilities and in accordance with Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer testimonials, placing emphasis on feedback describing PTSD symptom improvement and emotional well-being.


We juxtaposed product prices, confirming they were competitive and in line with the quality and efficacy of the nootropic.


We evaluated overall value by considering the balance of price, quality, and effectiveness to ensure the best possible return on investment.

Nootropics for PTSD in Summary

People who have survived natural disasters or traumatic events like wars, etc. may experience symptoms of post-traumatic stress disorder (PTSD). Psychotherapy and medication are common treatments, but nootropics are an emerging option for PTSD patients. The best nootropics for PTSD include Mind Lab Pro, Qualia Mind, L-Theanine, Ashwagandha, and Phenibut. These supplements work by lowering the stress response, promoting relaxation, reducing anxiety, and improving mood.

Mind Lab Pro enhances brain function and supports mental health. Qualia Mind also improves cognitive performance and mood. L-Theanine promotes relaxation and reduces stress and anxiety. Ashwagandha is an adaptogenic herb that reduces cortisol levels and promotes relaxation. Phenibut is a potent anxiolytic that regulates the nervous system and improves sleep quality.

Nootropics help regulate the brain’s chemistry by balancing neurotransmitter levels and promoting neuroplasticity. This results in improved cognitive function, reduced stress, and improved mood.

Using nootropics for PTSD is a safe and effective alternative to traditional treatments for mental health. However, it is essential to consult a medical professional before trying any new supplements. As with any medication or supplement, there may be side effects, contraindications, or interactions with other medications.

FAQs About Nootropics for PTSD

Are PTSD nootropics safe?

Most nootropics are considered safe when taken as directed. However, it is important to consult with a healthcare professional before taking any supplements, especially if you are on medication or have a history of medical conditions.

How long does it take for nootropics to show their effects on PTSD symptoms?

The time for noticeable effects varies by individual and nootropic. Some may show results within hours, while others may take weeks. Be patient and monitor your progress.

Can nootropics be combined with other PTSD treatments?

Nootropics may complement other PTSD treatments, such as therapy and medication.

Do nootropics work for everyone with PTSD?

Results vary by individual. Some may experience benefits, while others may not. It is essential to explore various nootropics to find the most suitable option.

Are there any risks associated with long-term nootropic use for PTSD?

Long-term nootropic use is generally safe; however, side effects or interactions with medications can occur. Consult a medical professional for personalized advice and regular monitoring of your condition.

Sources, Studies, and Scientific Research
  1. Jówko, Ewa, et al. “Effects of Rhodiola rosea supplementation on mental performance, physical capacity, and oxidative stress biomarkers in healthy men.” Journal of sport and health science 7.4 (2018): 473-480. ↩
  2. Ceremuga, Tomás Eduardo et al. “Effects of L-theanine on posttraumatic stress disorder induced changes in rat brain gene expression.” TheScientificWorldJournal vol. 2014 (2014): 419032. doi:10.1155/2014/419032 ↩
  3. Singh, Narendra et al. “An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda.” African journal of traditional, complementary, and alternative medicines : AJTCAM vol. 8,5 Suppl (2011): 208-13. doi:10.4314/ajtcam.v8i5S.9 ↩
  4. Hardman, Matthew I et al. “Acute phenibut withdrawal: A comprehensive literature review and illustrative case report.” Bosnian journal of basic medical sciences vol. 19,2 125-129. 20 May. 2019, doi:10.17305/bjbms.2018.4008 ↩
  5. Samokhvalov, Andriy V., et al. “Phenibut dependence.” Case Reports 2013 (2013): bcr2012008381. ↩