Top 5 Nootropics for Schizophrenia in 2024

Updated on March 19, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Article discussing the impact of nootropics on schizophrenia.

What are the best nootropics for schizophrenia?

Schizophrenia is a severe mental illness that affects millions of people worldwide. Its symptoms can be debilitating and make it difficult for those affected to function in their day-to-day lives.

In recent years, nootropics have garnered attention for their potential to improve cognitive function, memory, and concentration. While nootropics should not be considered a replacement for proper medication, they can be used in conjunction with treatment to boost cognitive function and improve quality of life for those with schizophrenia.

In this blog post, we will explore the top five nootropics that show promise in helping manage schizophrenia symptoms.

Best Nootropic for Schizophrenia

  • Performance Lab Mind — Best for overall neural health and performance
  • Piracetam — Best against psychotic disorders
  • Glycine — Great to boost brain cell health
  • Omega-3 — Great for regulating neural pathways
  • Melatonin — Great for improving blood flow to the brain

1. Performance Lab Mind

Performance Lab Mind is a highly effective nootropic supplement that aims to improve cognitive function and support brain health. Manufactured by Performance Lab, this supplement is designed to provide a short-term cognitive boost while helping the brain recover from mental exertion. One of the standout features of Performance Lab Mind is its select ingredients, which are in enhanced forms that allow for optimal nutrient delivery. This ensures that the brain receives the necessary nutrients for optimal function. 

The supplement offers a wide range of benefits, including promoting efficient mental processing, improving focus and attention, boosting memory and recall, and supporting overall brain health, effectively helping reduce the positive symptoms of schizophrenia. It works by increasing blood flow, oxygen, and glucose to the brain, fostering healthy brain function, and promoting neural regeneration. Performance Lab Mind’s formula contains natural and research-backed ingredients, such as Cognizin Citicoline, Ajipure L-Tyrosine, Maritime Pine Bark Extract, and Sharp-PS Green.


  • Enhances cognitive function and mental clarity
  • Improves memory and attention span
  • Increases focus and concentration
  • Enhances learning and problem-solving abilities
  • Supports brain health and neuroprotection


  • May take some time to see noticeable effects
  • May not be suitable for individuals with certain medical conditions or taking specific medications
  • Not recommended for pregnant or nursing women
  • Possible side effects such as headaches or nausea, though rare

Overall, Performance Lab Mind is an excellent choice for individuals looking to enhance their cognitive abilities and support their brain health. With its focus on delivering precise dosages of effective ingredients, this nootropic supplement stands out as a reliable option in the market.

2. Piracetam

Piracetam is one of the most well-known and widely used nootropics. Its chemical structure is derived from gamma-aminobutyric acid (GABA) and acetamide. Piracetam enhances brain neurotransmission by modulating ion channels, specifically calcium channels, leading to increased neuronal excitability. It also enhances the function of the neurotransmitter acetylcholine through muscarinic receptors.

Studies have shown that piracetam increases oxygen consumption in the brain and improves glucose metabolism.(1) Researchers found to have neuroprotective effects, reducing cell damage in hypoxic conditions. Additionally, piracetam has been shown to improve interhemispheric transmission in the brain.(1)

One of the key benefits of piracetam is its ability to improve memory and cognitive function. It has been studied for its potential in treating conditions such as dementia and Alzheimer’s disease. However, it is important to note that piracetam is not a cure for these conditions, but rather a supportive treatment.

Piracetam is well-tolerated and has a low risk of side effects. It is available as a dietary supplement in many countries, although in some places it may require a prescription. The recommended dosage of piracetam varies depending on the individual and the desired effects.


  • Enhances memory and learning ability
  • Improves cognitive function and mental performance
  • Increases focus and attention span
  • Helps with symptoms of age-related cognitive decline


  • Individual responses can vary, with some people experiencing no benefits
  • May have contraindications for certain medical conditions
  • Not recommended for pregnant or nursing women

Overall, piracetam is a popular choice among individuals looking to enhance their cognitive abilities and improve memory and focus. It is important to consult with a healthcare professional before starting any supplement regimen to ensure safety and effectiveness.

3. Glycine

Glycine, also known as 2-Aminoacetic Acid or Gly-G, is a powerful supplement that has shown promising benefits for treating schizophrenia. In addition to its nootropic properties, glycine has been found to enhance sleep quality and reduce symptoms of OCD. 

Glycine is an amino acid that acts as a precursor and derivative of glycine, making it a key component in the treatment of schizophrenia. Physicians often prescribe glycine to patients with schizophrenia, as it has been shown to help ease negative symptoms associated with the disorder.(2)

Research studies have demonstrated the positive effects of glycine supplementation on schizophrenia symptoms. In one notable study, 17 individuals with schizophrenia took glycine supplements in addition to their regular medication for a period of 6 weeks.(3) The results showed a significant reduction in negative symptoms of schizophrenia, as well as improvements in cognitive and positive symptoms.

It is important to note that glycine supplements should be taken under the guidance of a healthcare professional. They can help determine the dosage and ensure there are no potential risks, side effects, or interactions with other medications.


  • Improves sleep quality and promotes relaxation
  • Supports mood regulation and stress reduction
  • Has anti-inflammatory effects
  • Supports gut health and digestion


  • Individual responses can vary
  • Not recommended for pregnant or nursing women

In conclusion, glycine is a natural and promising option for individuals with schizophrenia. Its ability to address negative symptoms and improve cognitive function makes it a valuable addition to traditional antipsychotic medications. However, it is crucial to consult with a healthcare provider before adding any new supplements to your treatment plan.

4. Omega-3

Omega-3 fatty acids have gained significant attention in recent years for their potential benefits in improving brain health. These essential fats can be found in fatty fish, such as salmon and sardines, as well as in flaxseeds, chia seeds, and walnuts. Omega-3 fatty acids have been extensively studied for their ability to reduce inflammation and oxidative stress in the brain, which are believed to be involved in the development and progression of mental health disorders, including schizophrenia.

There’s some researchers’ evidence that individuals with higher blood levels of omega-3 fatty acids have better cognitive function and social functioning. In a study conducted on people at high risk of developing schizophrenia, it was found that taking fish oil supplements enriched with omega-3 fatty acids helped prevent the onset of the disorder.(4) Another study demonstrated that omega-3 supplementation improved cognition in individuals with schizophrenia.(5)


  • Supports cognitive function and memory
  • Reduces inflammation and supports heart health
  • Improves mood and helps with depression
  • Supports eye health and reduces the risk of certain eye conditions


  • Large doses may have potential risks for certain individuals, such as bleeding disorders
  • May not have immediate noticeable effects
  • Not recommended for individuals with seafood allergies or sensitivities

While omega-3 fatty acids cannot replace traditional treatment for schizophrenia, they offer an additional avenue for managing symptoms and improving overall brain health. Incorporating foods rich in omega-3 fatty acids into your diet or taking omega-3 supplements under the guidance of your healthcare provider would be beneficial. As with any supplement, it is important to consult with your treatment team before making any changes to your medication regimen.

5. Melatonin

Melatonin is a popular nootropic supplement known for its sleep-regulating properties. It is a hormone naturally produced by the body’s pineal gland that helps regulate the sleep-wake cycle. However, melatonin has also been found to have other cognitive benefits, making it a suitable option for individuals with schizophrenia.

Melatonin helps promote better sleep quality and duration, which is crucial for individuals with schizophrenia who may experience sleep disturbances. A good night’s sleep contributes to better mental health by reducing symptoms such as anxiety and depression.

Additionally, melatonin acts as a powerful antioxidant, protecting brain cells against oxidative stress and inflammation.(6) This is especially beneficial for individuals with schizophrenia, as oxidative stress and inflammation are believed to play a role in the development and progression of this condition.

Furthermore, melatonin has been found to have neuroprotective properties, supporting brain health and function.(7) It helps improve cognitive function, including memory and attention, which can be impaired in individuals with schizophrenia.

It is important to note that melatonin should be taken under the guidance of a healthcare professional, as dosage and timing vary depending on individual needs. It is also important to consider potential interactions with other medications or supplements.


  • Regulates sleep-wake cycles and improves sleep quality
  • Helps with jet lag and adaptation to shift work schedules
  • Effective in managing insomnia


  • May not be effective for everyone or all sleep disorders
  • May cause side effects such as drowsiness, vivid dreams, or headaches

In conclusion, melatonin is a beneficial nootropic supplement for individuals with schizophrenia. Its sleep-regulating properties, antioxidant effects, and neuroprotective benefits make it a valuable addition to a comprehensive treatment plan for this condition.

How Do Nootropics for Schizophrenia Work?

Nootropics for schizophrenia work by targeting various aspects of brain function to help alleviate symptoms and improve cognitive abilities. Schizophrenia is a complex mental disorder, and while nootropics cannot cure it, they provide benefits in managing the condition. These supplements aim to enhance brain health and function, which can have a positive impact on individuals with schizophrenia.

One way that nootropics work is by increasing the availability of neurotransmitters in the brain. Neurotransmitters are chemical messengers that facilitate communication between brain cells. Imbalances in neurotransmitters, such as dopamine and glutamate, are believed to contribute to the symptoms of schizophrenia. By promoting a healthier balance of these neurotransmitters, nootropics help alleviate symptoms.

Additionally, nootropics improve cognitive function, including memory, attention, and executive functioning. These cognitive enhancers can support individuals with schizophrenia in managing cognitive deficits often associated with the disorder.

It is important to note that nootropics should not be viewed as a standalone treatment for schizophrenia. They are best used with other forms of therapy, such as medication and psychological interventions. Before considering the use of nootropics for schizophrenia, individuals should consult with a healthcare professional to ensure they are taking the appropriate supplements and to discuss any potential interactions with other medications.

Overall, while nootropics can provide potential benefits for individuals with schizophrenia, they should be used as part of a comprehensive treatment approach and under the guidance of a healthcare professional.

How We Picked the Top Nootropics for Schizophrenia

Our selection of the top nootropics for schizophrenia was guided by a rigorous review process. We took into account factors such as efficacy, ingredient composition, brand standing, transparency, manufacturing methods, consumer feedback, cost, and value. We examined each of these criteria to provide readers with a comprehensive and trustworthy list of the best nootropics for managing schizophrenia symptoms.


Our analysis comprised clinical trials and user testimonials to measure improvements in schizophrenia symptoms, particularly focusing on cognitive function, thought clarity, and mood stabilization.


We rigorously evaluated each formula, favoring proven, natural, and premium-quality ingredients that can help manage schizophrenia symptoms.

Scientific Backing

We relied on peer-reviewed research and meta-analyses to validate the effectiveness of the main ingredients in managing schizophrenia.


We evaluated optimal dosages and ingredient proportions, ensuring they are in line with recognized research for peak effectiveness.


We confirmed the safety of each ingredient, considering possible side effects and interactions, and verifying compliance with regulatory standards. We prioritized FDA-approved ingredients.

Brand Reputation

We assessed the reliability and trustworthiness of each brand through consumer reviews, expert recommendations, and company history.

Product Transparency

We appreciated full disclosure of ingredients, including their sources and quantities, to aid consumers in making knowledgeable choices.

Manufacturing Process

We inspected the manufacturing standards, giving preference to products produced in accredited facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We scrutinized real customer feedback, valuing testimonies that detail improvements in managing schizophrenia symptoms and cognitive enhancements.


We compared the prices of the products, ensuring they are competitive and commensurate with the quality and effectiveness of the nootropic.


We evaluated the overall value, considering the balance of price, quality, and efficacy to assure optimal return on investment for managing schizophrenia symptoms with these nootropics.


Nootropics are a class of supplements improve cognitive function and reduce symptoms of various mental health conditions, including schizophrenia. Some researchers have presented evidence that nootropics significantly reduced schizophrenia symptoms and people with schizophrenia find them helpful in managing their condition. The best nootropics for schizophrenia include Performance Lab Mind, Piracetam, Glycine, Omega-3, and Melatonin.

Performance Lab Mind is a top choice for its ability to promote efficient mental processing, reduce stress, and support healthy brain function. Piracetam is a nootropic stack that enhances memory, focus, and motivation, making it ideal for individuals with ADHD. Glycine is a great option for reducing stress, anxiety, and brain fog, while Omega-3 supports brain cell regeneration and cognitive function. Melatonin improves sleep patterns and protects against oxidative stress from blue light exposure.

When selecting the best nootropics, we considered factors such as ingredients, dosage, reviews, price, and effectiveness. These supplements are beneficial for individuals with schizophrenia as they help improve cognitive function and support overall brain health.

It’s important to note that while most nootropics are safe when taken in recommended doses, it’s always advisable to consult with a healthcare professional before starting any new supplement regimen. Nootropics should be used responsibly and with healthy lifestyle practices, including adequate sleep, nutrition, and exercise. Overall, incorporating the right nootropics into your routine helps optimize brain function and support your cognitive health.


Are nootropics safe to take for schizophrenia?

When taken as directed, most nootropics are considered safe. However, it’s important to consult with a healthcare professional before starting any new supplement, especially if you have any underlying health conditions or are taking medications.

Have researchers provided enough evidence to support the use of nootropics for schizophrenia?

The evidence supporting the use of nootropics for schizophrenia is limited. While some research suggests that certain nootropics, such as taurine and probiotics, help reduce symptoms of schizophrenia, other studies have found that they may not work for everyone.

How long does it take for nootropics to work for schizophrenia?

The time it takes for nootropics to work for schizophrenia can vary depending on the specific supplement and the individual. Some studies have shown benefits of nootropics for schizophrenia after just 8-12 weeks of use, while others may take longer to see improvement.

Do I need my doctor’s approval to take nootropics for schizophrenia?

While there is no evidence suggesting that nootropics can directly trigger psychosis in people with schizophrenia, it is important to talk to your doctor before taking any supplements for schizophrenia, as some supplements may interact poorly with prescribed medications or have unwanted side effects.

Sources, Studies, and Scientific Research
  1. Noorbala, A A et al. “Piracetam in the treatment of schizophrenia: implications for the glutamate hypothesis of schizophrenia.” Journal of clinical pharmacy and therapeutics vol. 24,5 (1999): 369-74. doi:10.1046/j.1365-2710.1999.00238.x ↩ ↩
  2. Wheeler, M. D., et al. “Glycine: a new anti-inflammatory immunonutrient.” Cellular and Molecular Life Sciences CMLS 56 (1999): 843-856. ↩
  3. Javitt, D C et al. “Adjunctive high-dose glycine in the treatment of schizophrenia.” The international journal of neuropsychopharmacology vol. 4,4 (2001): 385-91. doi:10.1017/S1461145701002590 ↩
  4. Hsu, Mei-Chi et al. “Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms.” Lipids in health and disease vol. 19,1 159. 3 Jul. 2020, doi:10.1186/s12944-020-01337-0 ↩
  5. Peet, Malcolm, and Caroline Stokes. “Omega-3 fatty acids in the treatment of psychiatric disorders.” Drugs vol. 65,8 (2005): 1051-9. doi:10.2165/00003495-200565080-00002 ↩
  6. Duan, Cathy et al. “Therapeutic use of melatonin in schizophrenia: A systematic review.” World journal of psychiatry vol. 11,8 463-476. 19 Aug. 2021, doi:10.5498/wjp.v11.i8.463 ↩
  7. Suresh Kumar, P N et al. “Melatonin in schizophrenic outpatients with insomnia: a double-blind, placebo-controlled study.” The Journal of clinical psychiatry vol. 68,2 (2007): 237-41. doi:10.4088/jcp.v68n0208 ↩