7 Best Nootropics for Serotonin in 2024 (Brain Supplements)

Updated on January 30, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Enhancing brain serotonin with nootropic supplements for improved neural connections.

What are the best nootropics for serotonin?

Are you feeling down and struggling to find the energy to focus on daily tasks? You’re not alone. Many of us experience low mood and lack of mental energy from time to time.

But there is hope. Nootropics, also known as “smart drugs,” are natural supplements that boost serotonin levels, improve mood, and increase mental energy. In this article, we’ll explore the seven best nootropics for serotonin, so you can feel your best and achieve your goals.

Ready to take your mental performance to the next level? Let’s dive in.

Best Nootropic for Serotonin

  • Mind Lab Pro — Best nootropic stack to elevate mood
  • Alpha Brain — Best nootropic stack against mood disorders
  • 5-HTP —  Best amino acid to regulate levels of serotonin
  • Turmeric — Great for improving cognition
  • Omega-3 — Great to ease depressive mindset
  • Rhodiola Rosea — Best antidepressant herbal nootropic
  • L-Theanine — best nootropics for depression

How to Choose the Best Nootropics for Serotonin?

Selecting the ideal nootropics for serotonin involves careful consideration of several factors that influence their efficacy and safety. Understanding these aspects can help you make an informed decision tailored to your cognitive needs and wellness goals.

FactorDescriptionWhy It’s Important
Ingredient QualityThe purity and sourcing of nootropic ingredients.Ensures the effectiveness and minimizes the risk of contaminants.
Scientific BackingResearch and clinical trials supporting the use of nootropics for serotonin.Provides evidence of efficacy and suggested dosages for optimal results.
Synergistic FormulationHow well the ingredients work together in a nootropic blend.Enhances the overall impact on serotonin levels and cognitive function.
Side Effect ProfileThe potential adverse effects and interactions of the nootropic.Helps maintain health and avoid negative reactions.
Brand ReputationThe credibility and user testimonials regarding the nootropic brand.Increases confidence in the product’s reliability and quality.
  • Ingredient Quality: High-quality ingredients are crucial for ensuring the nootropic is both safe and effective. Look for products that use standardized extracts and have a clear supply chain.
  • Scientific Backing: Evidence-based nootropics are more likely to provide the benefits they claim. Research studies and clinical trials can validate the effects of the nootropics on serotonin enhancement.
  • Synergistic Formulation: Some nootropics work better together. Finding a product that combines ingredients in a way that maximizes their effects can lead to better outcomes.
  • Side Effect Profile: Understanding the side effects and interactions can help prevent unwanted consequences and ensure that the nootropic will not adversely affect your health.
  • Brand Reputation: A reputable brand generally indicates that the nootropics are of high quality and that the company engages in good manufacturing practices.

The Best Nootropics for Serotonin of 2024

According to our in-depth research and testing, the best nootropics for serotonin are:

1. Mind Lab Pro

Mind Lab Pro is a natural nootropic supplement that has been designed to help people improve their mental clarity, focus, and motivation while also reducing anxiety and brain fog. The supplement is made up of 11 premium-grade nootropic ingredients that have been expertly blended and precisely dosed to work better together. Mind Lab Pro has been scientifically proven to enhance brainpower through double-blind placebo-controlled human trials.

The supplement is made using premium-grade research-backed ingredients that have been ethically sourced to ensure its purity and potency. Mind Lab Pro is vegan-certified, and its capsules are made from clean plant-based NutriCaps for optimal absorption and to support gut health. Mind Lab Pro is stimulant-free and delivers measurable results that accumulate subtly over time.


  • Scientifically proven to enhance brainpower
  • Includes pure and potent ingredients
  • Comprised of NutriCaps prebiotic capsules for optimal absorption
  • Improves mental agility, motivation, and mood


  • Effect may be less profound than expected for some users

The improvements you see from Mind Lab Pro will steadily increase the longer you take it. Mind Lab Pro is the cleanest, greenest brain supplement on the planet, and it stands for the highest quality.

2. Alpha Brain

Alpha Brain is a nootropic supplement that promises to enhance cognitive performance and increase alertness in daily life. It is made up of natural ingredients that boast several benefits, such as nutrients that enhance brain function and GPC choline, which has positive effects on mood and memory. Alpha Brain also includes the popular nootropic ingredient Huperzia serrata, which is rich in Huperzine A – an essential ingredient that supports the neurotransmitter acetylcholine.


  • Improves memory, focus, and processing speed
  • Regulates neurotransmitters like GABA and serotonin in the brain
  • Facilitates key brain functions for improved cognition and mental prowess


  • Not recommended for pregnant or nursing women
  • May cause side effects like nausea, jitters, and headaches

Ultimately, Alpha Brain, like most nootropic supplements, has its pros and cons, but if you’re looking to improve your focus and concentration, it may be worth giving it a try.

3. 5-HTP (Hydroxytryptophan)

5-HTP (Hydroxytryptophan) is a nootropic supplement that is becoming increasingly popular due to its ability to naturally increase serotonin levels in the body. As a derivative of the essential amino acid L-tryptophan, it acts as a precursor to 5-hydroxytryptamine (serotonin). 5-HTP supplements are believed to be a natural treatment for depression and obesity.

The body produces L-5-Hydroxytryptophan from the amino acid L-tryptophan with the help of tryptophan hydroxylase, and another enzyme, aromatic amino acid decarboxylase, then transforms 5-HTP into serotonin, which plays a crucial role in regulating mood, appetite, and other cognitive processes.(1) 5-HTP supplements are effective as a natural anxiolytic and stress reducer, to ease pain associated with fibromyalgia and arthritis, and promote weight loss.


  • Enhances mood and improves cognitive function
  • Reduces stress and anxiety
  • Modulates brain chemicals associated with mood


  • May have side effects like nausea, diarrhea, and dizziness for some people
  • Long-term effects are not well-established

It is important to consult with your healthcare provider before taking 5-HTP supplements as they can interfere with prescription medication that alters serotonin and/or melatonin levels. Overall, 5-HTP supplements effectively increase serotonin levels in the brain, thus improving mood and mental energy.

4. Turmeric

Turmeric is a widely studied spice that contains curcumin, a natural compound with potent anti-inflammatory and antioxidant properties. Curcumin has been found to play an active role in the treatment of various central nervous system disorders, including depression, epilepsy, and other neurodegenerative and neuropsychiatric disorders. The molecule has shown neuroprotective effects in animal models of depression, tardive dyskinesia, and diabetic neuropathy.(2)

Curcumin enhances the level of neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and modulates various neurotransmitter levels in the brain while inhibiting reactive astrocyte expression and preventing cell death. Studies have even suggested that it effectively disaggregate beta-amyloid and prevent fibril and oligomer formation to treat Alzheimer’s disease.(3)


  • Has anti-inflammatory and antioxidant properties
  • Helps with pain relief and an overall mood enhancer


  • May cause stomach upset
  • May interact with certain medications

A downside to curcumin is its poor oral bioavailability, but this can be enhanced with bioavailability enhancing agents such as piperine. Turmeric is an excellent supplement option for those looking to naturally boost their serotonin levels and improve their mental health.

5. Omega-3

Omega-3 is one of the best nootropics for boosting mood, improving cognitive function, and reducing inflammation in the brain. It is a powerful supplement that improves brain health and help to prevent cognitive decline. Omega-3 is one of the most important nutrients for brain health and is found in foods such as oily fish, nuts, and seeds. It contains fatty acids such as EPA and DHA, which are essential for proper brain function.

Omega-3 has been shown to improve memory, attention, and overall cognitive performance in both adults and children. It also improves mood and reduces symptoms of depression and anxiety. Omega-3 has anti-inflammatory properties and protects the brain cells from damage and prevent cognitive decline.(4)


  • Works to elevate low serotonin levels
  • Reduces inflammation and relieves oxidative stress
  • Lowers risk of heart disease


  • May cause belching, bad breath, and nausea in some users
  • May not be effective for everyone

It is important to take omega-3 supplements regularly to ensure you are getting enough of these essential fatty acids for optimal brain health. Choosing the right source of omega-3 is important to ensure you are getting a high-quality supplement that is free from contaminants.

6. Rhodiola Rosea

Rhodiola Rosea is a popular nootropic supplement that has been used for centuries to combat fatigue and enhance cognitive function. It is an adaptogenic herb that helps the body adapt to stress and maintain a balanced physiological state. Rhodiola Rosea has also been found to improve attention, short-term memory, and learning.

Additionally, it has demonstrated potential as a natural mood enhancer and anxiety reducer. It enhances cognitive function by modulating the levels of key neurotransmitters such as serotonin, dopamine, and norepinephrine.(5) These neurotransmitters play crucial roles in mood regulation, motivation, and cognitive function, and their modulation may underlie Rhodiola Rosea’s nootropic effects.


  • Improves mental performance under stress
  • Reduces fatigue and anxiety
  • Works as a natural anti-depressant to improve your mood


  • May cause side effects like dry mouth or dizziness
  • May interact with certain medications

Rhodiola Rosea also contains potent antioxidant compounds that help neutralize free radicals and protect cells from oxidative damage. Its antioxidant properties may contribute to its neuroprotective effects and overall health benefits. All these benefits make Rhodiola Rosea a valuable natural supplement for enhancing mental performance and overall well-being.

7. L-Theanine

L-Theanine is a naturally occurring amino acid that is found in tea leaves. Its ability to enhance relaxation and reduce stress and anxiety levels has earned it recognition as a nootropic ingredient. Many studies have shown that L-Theanine improves focus and attention when combined with caffeine. It works to modulate the stimulating properties of caffeine, resulting in improved cognitive performance. L-Theanine has also been associated with enhancing sleep quality and promoting cardiovascular health. Its ability to protect the brain from age-related cognitive decline makes it an ideal supplement for those who are concerned about their cognitive health.(6) L-Theanine has been found to have antioxidant properties that protect the body from oxidative stress and free radicals, contributing to overall health.(7)


  • Reduces anxiety and stress
  • Improves mental focus and alertness
  • Enhances neural pathways for a healthy brain and body


  • May cause side effects like sleepiness
  • May interact with certain medications
  • Long-term effects not well-established

Additionally, L-Theanine has been found to promote the production of neurotransmitters such as serotonin and dopamine, which regulate emotions and improve mood. With all these benefits, it is easy to see why L-Theanine has gained popularity as a versatile nootropic ingredient. It truly is a promising and natural supplement that contributes to one’s overall health and well-being.

How Do Nootropics for Serotonin Work?

Nootropics are substances that enhance cognitive function and boost mood and mental energy. The best nootropics for serotonin work by modulating levels of neurotransmitters such as dopamine and serotonin, or by increasing blood flow to the brain. By improving focus, memory, and vigilance, they reduce fatigue and enhance motivation.

These substances act on the brain by increasing dopamine levels in the brain, reducing inflammation, improving blood flow, and encouraging cell growth. Specifically, L-Theanine plays a role in modulating the brain chemicals dopamine, serotonin, and GABA. Some of the most effective ingredients include caffeine, Bacopa monnieri, Rhodiola rosea, and ashwagandha. These ingredients work together to increase energy levels and mental performance while also reducing stress and anxiety.

Overall, nootropics offer a natural and effective way to improve cognitive performance, but it’s important to maintain a healthy lifestyle and consult with a physician before adding any supplements to your diet.

What to Consider Before Buying Nootropics for Serotonin?

Before purchasing nootropics to boost serotonin levels, it’s important to reflect on several factors that can influence their compatibility with your unique needs and lifestyle.

1. Personal Health and Sensitivities

Before starting any new supplement regimen, consider your current health status and any sensitivities or allergies you may have. Certain nootropic ingredients might not be suitable for everyone, and understanding your own body is key to selecting the right product.

2. Desired Outcomes

Identify what you aim to achieve with nootropics. Whether it’s mood elevation, cognitive enhancement, or stress reduction, the intended outcome will guide your choice of nootropic.

3. Interaction With Other Supplements or Medications

If you’re currently taking other supplements or medications, it’s important to consider how nootropics might interact with them. Some nootropic ingredients can affect the metabolism of other drugs, potentially leading to adverse effects.

4. Lifestyle and Diet

Your lifestyle and dietary habits can influence the effectiveness of nootropics. For instance, a diet rich in nutrients that support serotonin production may complement the use of nootropics, while certain lifestyle choices might diminish their effectiveness.

5. Budget and Cost-Effectiveness

Finally, consider your budget and the cost-effectiveness of the nootropic. Higher-priced products do not always guarantee better results, and it’s important to find a balance between quality and affordability.

How We Picked the Top Nootropics for Serotonin

We employed a comprehensive review process to identify the best nootropics for boosting serotonin levels, mood, and mental energy. Our selection criteria included effectiveness, ingredients, scientific evidence, dosage, safety, brand reputation, product transparency, manufacturing process, user reviews, price, and overall value. By evaluating each of these factors, we aimed to provide readers with a reliable and well-rounded list of the top serotonin-enhancing nootropics.


We analyzed clinical trials and user experiences to measure serotonin elevation, mood enhancement, and increased mental energy as primary outcomes.


We examined each formula thoroughly, prioritizing evidence-based, natural, and high-quality ingredients that effectively support serotonin production and function.

Scientific Evidence

We referred to peer-reviewed research and meta-analyses to confirm the efficacy of key ingredients in boosting serotonin levels and improving mood and mental energy.


We evaluated optimal dosages and ingredient ratios, ensuring their alignment with established research for maximum effectiveness in serotonin support.


We assessed the safety of each ingredient by considering potential side effects and interactions and verifying compliance with regulatory guidelines. We prioritized FDA-approved ingredients.

Brand Reputation

We appraised brands’ credibility, and trustworthiness by examining customer reviews, expert endorsements, and company history.

Product Transparency

We valued comprehensive ingredient disclosure, including sources and concentrations, to enable informed consumer decision-making.

Manufacturing Process

We scrutinized manufacturing standards, giving preference to products made in certified facilities and adhering to Good Manufacturing Practices (GMP).

User Reviews

We analyzed genuine customer feedback, emphasizing testimonials that describe mood enhancement, increased mental energy, and serotonin level improvements.


We compared product prices to ensure they were competitive and in line with the quality and efficacy of the nootropic.


We determined overall value by considering the balance of price, quality, and effectiveness, ensuring optimal return on investment for consumers.

Nootropics for Serotonin in Summary

Serotonin is a neurotransmitter that is responsible for regulating mood, appetite, and sleep. Nootropics are supplements that improve cognitive function, and some of them have been found to boost serotonin levels too.

Mind Lab Pro is one of the best nootropics for serotonin. It contains phosphatidylserine, which has been shown to help lower symptoms of anxiety and depression. Another popular nootropic for serotonin is Alpha Brain, which contains Alpha GPC that impacts alpha brain waves to improve focus and motivation.

Additionally, 5-HTP, a naturally occurring amino acid, is used to boost serotonin levels and can be found in many nootropic supplements. Turmeric and Omega-3 have also been found to have a positive impact on serotonin levels, while Rhodiola Rosea and L-Theanine promote relaxation and calmness.

While selecting the best nootropic for serotonin, it’s essential to look for products backed by solid scientific research and clinical trials. It is also important to consult with a healthcare professional to determine the best supplement to meet personal needs and goals.

FAQs About Nootropics for Serotonin

Are nootropics for serotonin safe to use?

Most natural and high-quality nootropics are generally safe to use, especially when taken in recommended dosages. However, some people may experience side effects such as headaches, insomnia, nausea, or anxiety, particularly when taking synthetic or high-dose nootropics. It’s always best to consult with a healthcare professional before starting any new supplement or medication.

Can nootropics help with major depressive disorder?

Research shows that certain nootropics may help increase levels of serotonin in the prefrontal cortex, which could potentially benefit patients with major mood disorders like depression.

Are high doses of mood-boosting nootropics safe?

It depends on the specific nootropic and the individual. While some nootropics may be safe at high doses, others may have side effects or interactions with other medications. It is always best to consult with a healthcare professional before taking high doses of any nootropic.

Will nootropics work for everyone with low serotonin?

No, nootropics may not work for everyone. The effectiveness of nootropics can vary based on individual factors such as genetics, lifestyle, and underlying health conditions.

Can nootropics be used as a replacement for prescription medications?

No, nootropics should not be used as a replacement for prescription medications without consulting with a healthcare professional first.

Sources, Studies, and Scientific Research
  1. Maffei, Massimo E. “5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology.” International journal of molecular sciences 22.1 (2020): 181. ↩
  2. Banji, David, Otilia JF Banji, and Kavati Srinivas. “Neuroprotective effect of turmeric extract in combination with its essential oil and enhanced brain bioavailability in an animal model.” BioMed Research International 2021 (2021). ↩
  3. Mishra, Shrikant, and Kalpana Palanivelu. “The effect of curcumin (turmeric) on Alzheimer’s disease: An overview.” Annals of Indian Academy of Neurology 11.1 (2008): 13. ↩
  4. Kiecolt-Glaser, Janice K., et al. “Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial.” Brain, behavior, and immunity 25.8 (2011): 1725-1734. ↩
  5. Khanum, Farhath, Amarinder Singh Bawa, and Brahm Singh. “Rhodiola rosea: a versatile adaptogen.” Comprehensive reviews in food science and food safety 4.3 (2005): 55-62. ↩
  6. Vuong, Quan V., Michael C. Bowyer, and Paul D. Roach. “L‐Theanine: properties, synthesis and isolation from tea.” Journal of the Science of Food and Agriculture 91.11 (2011): 1931-1939. ↩
  7. Kimura, Kenta, et al. “L-Theanine reduces psychological and physiological stress responses.” Biological psychology 74.1 (2007): 39-45. ↩