Can You Take Nootropics with Antidepressants?

Updated on February 23, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Understanding the Interaction between Nootropics and Antidepressants.

Can you take nootropics with antidepressants?

Taking care of one’s mental health has become increasingly important in today’s fast-paced world.

Many individuals rely on antidepressant medications to manage their symptoms. Others seek to enhance their cognitive abilities through the use of nootropics. Both are safe to use independently,(1) with no negative long-term effects. However, a common question arises: can I take antidepressants with nootropics

This article will analyze the risk of side effects, based on factual data, to help you learn more. So, if you’re considering combining nootropics with antidepressants, then read on to make an informed decision!

Understanding Nootropics and Antidepressants

Antidepressants and nootropics and are substances that impact brain function and play a role in cognitive enhancement and mood regulation. They are especially helpful for individuals with mental health disorders, as well as those who experience regular, mild depression.

Nootropics are compounds that are often referred to as “smart drugs”,(2) and are used to help improve mood and cognitive function. Nootropics have the ability to improve various aspects of cognitive function, such as memory, focus, creativity, and motivation. The improved cognitive action also has the ability to improve mood swings and reduce depression.

On the other hand, antidepressants are medications that are primarily used to treat depression and other mood disorders. They work by increasing the levels of certain chemicals in the brain, such as norepinephrine, serotonin and dopamine, which are responsible for regulating mood and emotions.

Common types of nootropic supplements for depression and improved brain function include:

  1. Racetams: This group of compounds, including piracetam, aniracetam, and oxiracetam, work to improve mood and cognitive function, as well as enhance memory by increasing the levels of neurotransmitters in the brain. This also allows for the nootropic to relieve depression.
  2. Modafinil: This prescription medication promotes wakefulness and alertness, improving focus and reducing fatigue, making it one of the best cognitive enhancers.
  3. Omega-3 fatty acids: Found in fish oil, these compounds support brain health and help with cognitive function and mood regulation.

Some of the most commonly used antidepressants include:

  1. Selective serotonin reuptake inhibitors (SSRIs): These medications, such as fluoxetine (Prozac) and sertraline (Zoloft), increase the levels of serotonin in the brain, helping to alleviate symptoms of depression and anxiety.(3)
  2. Serotonin-norepinephrine reuptake inhibitors (SNRIs): Medications like venlafaxine (Effexor) and duloxetine (Cymbalta) work on both serotonin and norepinephrine, providing relief for mood disorders.(4)
  3. Tricyclic antidepressants (TCAs): Older antidepressants like amitriptyline and imipramine are still used in certain cases. They affect multiple neurotransmitters, including serotonin and norepinephrine.

In summary, nootropics are compounds known for their cognitive-enhancing properties, while antidepressants are medications primarily used for mood regulation.

It’s safe to take nootropics and antidepressants independently, and both play important roles in impacting brain function and improving cognitive performance. However, it’s always best to consult with a healthcare professional before starting any new regimen with commonly prescribed antidepressants or nootropics. 

Interactions Between Nootropics and Antidepressants

Nootropics and antidepressants potentially interact and cause effects and risks when used in combination, especially if you’re using a new supplement that your body has not yet adjusted to.

Are nootropics safe with antidepressants? When considering the interaction between these substances, several key factors should be taken into account:

  1. Drug Interaction: Nootropics and antidepressants have the potential to interact with each other when taken simultaneously. This risk of adverse interaction leads to various effects in the body, which may influence the overall efficacy and safety of these medications. They also have the potential to have a negative interaction with other supplements or medications you are on, such as allergy medicine. This is why it is important to consult with a healthcare professional about your daily supplement regimen in order to ensure positive effects. 
  2. Neurotransmitters: Both nootropics and antidepressants affect neurotransmitters in the brain. Nootropics are often used to enhance cognitive function and work by modulating levels of neurotransmitters such as dopamine, acetylcholine, and glutamate. Antidepressants, on the other hand, primarily target serotonin, norepinephrine, and dopamine.
  3. Serotonin Syndrome: One of the potential risks associated with the interaction between nootropics and antidepressants is the development of serotonin syndrome. Serotonin syndrome occurs when there is an excess accumulation of serotonin in the body, leading to symptoms such as agitation, confusion, rapid heart rate, and elevated body temperature. It can be a life-threatening condition and requires immediate medical attention.
  4. Side Effects: Combining nootropics and antidepressants may increase the risk of experiencing side effects. Each medication has its own set of potential side effects, and their interaction can lead to an amplification or alteration of these effects. Common side effects of nootropics include headaches, gastrointestinal issues, and insomnia, while antidepressant side effects may include nausea, drowsiness, and sexual dysfunction.
  5. Risks: It is important to note that there is limited research on the specific interactions between different types of nootropics and antidepressants. Therefore, the risks associated with their combined use may not be fully understood. Consequently, it is crucial for individuals considering combining these medications to consult with a healthcare professional who can provide personalized advice based on their medical history and specific circumstances.

Due to limited scientific evidence regarding these interactions, it is important for individuals to seek professional guidance when considering simultaneous use. Overall, the interaction between nootropics and antidepressants has potentially significant effects on neurotransmitter regulation and may increase the risk of serotonin syndrome. Additionally, combining these medications may amplify the occurrence of side effects. 

The Risk of Serotonin Syndrome

Serotonin syndrome is a potential risk when combining nootropics and antidepressants. It is a rare but potentially life-threatening condition that occurs when there is an excess of serotonin in the brain. Serotonin is a neurotransmitter that plays a crucial role in regulating mood, appetite, sleep, and other bodily functions.

Serotonin syndrome has the potential to cause a wide range of symptoms, including:

  • Agitation and restlessness
  • Confusion and disorientation
  • Rapid heart rate and high blood pressure
  • Dilated pupils
  • Excessive sweating
  • Tremors and muscle twitching
  • Shivering and goosebumps
  • Diarrhea
  • Headache

In severe cases, serotonin syndrome can lead to seizures, high fever, irregular heartbeat, unconsciousness, and even death. It is important to seek medical attention immediately if you experience any of these symptoms.

  • Causes: Serotonin syndrome can occur when there is an excess of serotonin in the brain. This can happen when combining certain medications that increase serotonin levels, such as nootropics and antidepressants. Some antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), work by blocking the reabsorption of serotonin, leading to increased levels in the brain. When combined with certain nootropics that also affect serotonin levels, the risk of serotonin syndrome increases.
  • Treatment: If you suspect you may be experiencing serotonin syndrome, it is important to seek immediate medical attention. Treatment typically involves discontinuing the medications that are contributing to the condition and managing symptoms. In severe cases, hospitalization may be required, and additional measures such as the administration of intravenous fluids, sedatives, or muscle relaxants may be necessary. It is important to follow the guidance of a medical professional for proper diagnosis and treatment.

To avoid the risk of serotonin syndrome, it is essential to inform your healthcare provider about all the medications, including nootropics and antidepressants, that you are taking. They can provide guidance on potential interactions and help you make informed decisions regarding your treatment plan.

Conclusion: Can You Take Nootropics with Antidepressants?

In conclusion, the question of whether you can take nootropics with antidepressants requires careful consideration and consultation with a healthcare provider.

Several key points have emerged from the article, shedding light on the potential risks and safety considerations involved in this combination.

Here is a summary of those key points:

  • Combining nootropics with antidepressants can have unpredictable effects, as both substances may interact with each other and with the individual’s unique physiological makeup.
  • There is a potential risk, as nootropics can interact with antidepressants when taken together, causing side effects, adverse drug interactions, and changes in the efficacy of either medication.
  • Safety considerations are paramount when considering the combination of these two types of medication to improve cognitive function, as there may be a lack of comprehensive research regarding their interactions.

Ultimately, the advice and guidance of a healthcare provider should be sought if you are wondering if you can you take nootropics with antidepressant supplements. Medical experts offer tailored recommendations based on the individual’s specific circumstances.


Sources, Studies, and Scientific Research
  1. Afanasieva, O G et al. “Antidepressant, psychostimulant, and nootropic effects of major and trace element composition.” Bulletin of experimental biology and medicine vol. 155,2 (2013): 204-6. doi:10.1007/s10517-013-2113-5 
  2. Malík, Matěj, and Pavel Tlustoš. “Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs.” Nutrients vol. 14,16 3367. 17 Aug. 2022, doi:10.3390/nu14163367 
  3. Chu, Andrew. and Roopma Wadhwa. “Selective Serotonin Reuptake Inhibitors.” StatPearls, StatPearls Publishing, 1 May 2023. 
  4. Sansone, Randy A, and Lori A Sansone. “Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison.” Innovations in clinical neuroscience vol. 11,3-4 (2014): 37-42. 
chevron-down