Cyclazodone: Review of Nootropic Benefits, Uses, & Side Effects

Updated on March 19, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Overview of Cyclazodone's nootropic benefits, uses, and potential side effects.

This review will examine Cyclazodone’s nootropic features, benefits, and side effects. We will also discuss the appropriate dosage and how Cyclazodone can be used to improve cognitive function.

Cyclazodone is a centrally active stimulant created by the American Cyanamid Company in the 1960s. The drug is similar to pemoline and thozalinone, which are closely related. It has been investigated for its ability to reduce fatigue and as a possible anorectic (a drug that reduces appetite).

In recent years, Cyclazodone has gained popularity as a nootropic due to its stimulating and cognitive-enhancing effects. Biohackers use it as a smart drug to improve focus and concentration.

Let’s take a closer look at this intriguing nootropic and see what the research says about it.

Cyclazodone Review Summary

Cyclazodone is a potent stimulant with cognitive-enhancing and fatigue-reducing effects. It also has anorectic properties, helping to suppress appetite. As a nootropic, it can improve focus and concentration. However, there is limited research on Cyclazodone, which has not been approved for medical use in the United States.

Cyclazodone is 3-5 times stronger than its parent compound, Pemoline, and should be used cautiously. It is not recommended for those with a history of heart disease or high blood pressure.


  • Improves focus and concentration
  • A potent stimulant that reduces fatigue
  • Has appetite-suppressant properties


  • Limited research on its efficacy and safety in humans
  • not approved for medical use in the United States

What Is Cyclazodone?

Cyclazodone, also known as N-Cyclopropylpemoline, is a stimulant that belongs to the 4-oxazolidinone class. Cyclazodone is structurally similar to pemoline and 4-methylaminorex, both of which are banned in some countries due to their potentially dangerous side effects, liver toxicity being a common concern.

Cyclazodone enhances dopamine and norepinephrine in the brain, which is why people notice increased stimulation, focus, strength, blood pressure elevation, and mild euphoria. Cyclazodone has a stimulant effect that many people online report is similar to methylphenidate and amphetamine.

The inventors’ patents show that cyclazodone has a stronger central nervous system stimulant and anorexigenic impact than pemoline and is more potent (1). It also shows how it’s different from other N-lower-alkyl-substituted pemoline derivatives by having a higher therapeutic index (TI) with fewer side effects while maintaining patient safety.

How Does Cyclazodone Work In The Brain?

Cyclazodone works by binding to and activating the Trace Amine Associated Receptor 1 (TAAR1). This receptor is a key regulator of dopamine, serotonin, and noradrenaline levels in the brain (2).

By activating this receptor, Cyclazodone causes increased concentrations of these neurotransmitters in the synaptic cleft. This leads to cognitive and physical stimulation within the user.

Cyclazodone also has a high affinity for the dopamine transporter (DAT) and norepinephrine transporter (NET). This means it can inhibit reuptake and increase concentrations of dopamine and norepinephrine, thus enhancing their effects.

What Is Cyclazodone Used For?

Cyclazodone is used for its stimulating properties and as an anorexic agent. It has been studied for use in treating fatigue, narcolepsy, obesity, and Attention Deficit Hyperactivity Disorder (ADHD).

However, there is limited clinical research on Cyclazodone’s efficacy for these conditions, and it is not approved for any medical use in the United States. Off-label, it is used as a cognitive enhancer and energy booster for those seeking to improve focus and concentration.

A study on Cyclazodone’s parent compound, Pemoline, looked at 21 adolescents with an average age of 14 years old who were diagnosed with ADHD. The participants went through a 10-week, double-blind crossover design study of pemoline. Dosing was optimized to find the best efficacy and lowest side effects (3).

According to Bostic, J Q et al., the Pemoline treatment effectively reduced ADHD symptoms in adolescents when compared to the placebo. 60% of adolescents who took pemoline responded to treatment, compared to only 11% of those treated with a placebo. This response was the same regardless of gender or lifetime psychiatric comorbidity.

Since Cyclazodone is a more potent derivative of Pemoline, it is not surprising that it has similar effects in reducing ADHD symptoms and has been noticed in people who have used it off-label (4).

What Are The Benefits Of Cyclazodone For Cognition?

Cyclazodone is a potential nootropic and stimulant, but further scientific research is necessary to determine its safety and effectiveness. However, while it can be taken for research purposes or to treat ADHD, the lack of information regarding its side effects and toxicity should be a major concern.

Cyclazodone has similar effects to amphetamine, albeit much weaker. It has a low-to-moderate affinity for serotonin and is similar to other central nervous system stimulants. However, unlike methamphetamine, it does not cause physical dependence.

Overview of Cyclazodone benefits:

  • Cyclazodone exhibits central nervous system stimulant and antidepressant efficacy and potency
  • Possesses anorexic efficacy and potency with lesser toxicity, unlike that of d-amphetamine
  • Cyclazodone has cognitive and physical stimulation
  • Provides strong wakefulness and stimulation
  • Significantly boosts mood and motivation
  • Verbal fluency and sociability
  • Better focus and empathy

But, as with all nootropics, the effects and benefits vary from person to person. Individual factors such as age, weight, metabolism, and overall health can affect how well Cyclazodone works for you.

Where To Buy Cyclazodone Online?

If you want to purchase Cyclazodone, it’s important to note that it is not currently marketed or approved for medical use in the United States. As such, it can only be purchased online for research purposes.

It’s important to exercise caution and do thorough research on any vendor before purchasing Cyclazodone. Several vendors offer Cyclazodone in powder form, capsules, or tablets at varying doses.

What Do People Say About Cyclazodone On Reddit?

Let’s take a look at what Reddit users have to say about Cyclazodone:

According to Polaco157:

“As I figured it wud, the adrafinil significantly potentiated the effects. But the cyclazodone on its own was still very impressive. On an empty stomach, it kicks in ~30-40min. Lasts about 8hrs from the little I’ve seen. It provides strong wakefulness and stimulation.”

According to serduv:

“It’s less euphoric than Adderall but extremely potent and functional. It absolutely does what you want it to do if you’re trying to function at a decent level and/or prolong wakefulness. Very clean. It does elevate the mood just a bit as well – just not to where it’s outside of normal…”

According to labratdream:

It’s a serious stimulant of amphetamine potency and one-third of its cardiotoxicity. This is not something you should get into unless you know what you are doing. From personal and long-term experience ( like 3 years with breaks ) it’s stronger than methylphenidate. Typical dose is between 10-20mg right in the morning. It’s much more potent than fenozolone and thozalinone.”

How Do You Take Cyclazodone For Cognitive Enhancement?

We recommend taking Cyclazodone on an empty stomach in the morning or early afternoon. It’s important not to take it too late in the day, as it may affect sleep patterns. It’s also important to start with a low dose, gradually increasing as needed.

Cyclazodone should be cycled, taking breaks every few days to prevent tolerance buildup and prevent possible adverse effects.

It’s important to note that Cyclazodone is a stimulant, so it may not be suitable for individuals with heart conditions or high blood pressure. It’s always best to consult with a healthcare professional before starting any new nootropic supplement.

The ideal Cyclazodone dosage range is between 5 and 40 mg. Initially, beginners can start with a dose of 5 mg and increase this slowly until they have reached the desired level. However, some people go as high as 50 mg.

Dosage Levels:

  • Light: 5 – 10 mg
  • Moderate: 15 – 20 mg
  • Strong: 25 mg – 40 mg

If this is your first time trying Cyclazodone, you can also split your dose in half and take it twice a day. It’s important to pay attention to how your body responds and adjust accordingly. As with any nootropic or stimulant, it is not recommended to exceed the recommended dosage.

What Are The Side Effects Of Cyclazodone?

Among the common side effects of Cyclazodone are increased urination, dry mouth, and headaches. It may also elevate blood pressure.

Although cyclazodone has a lower abuse potential than many other stimulants, it still poses a risk of harm. Therefore, users should be aware of its side effects and follow the best harm-reduction practices to minimize their risks.

Immediate side effects of Cyclazodone:

  • Increased heart rate
  • Frequent urination
  • Dry mouth
  • Teeth grinding (prolonged usage)
  • Increased body temperature
  • Muscle cramps
  • Temporary erectile dysfunction

There are also after-effects associated with Cyclazodone use, which may include the following symptoms:


  • Anxiety
  • Mental fatigue
  • Delusion
  • Depersonalization
  • Depression
  • Headaches
  • Irritability
  • Motivation suppression
  • Psychosis
  • Tactile hallucinations

Most of these can be prevented or minimized by using Cyclazodone responsibly and taking regular breaks from its use.

What Nootropics Are Similar To Cyclazodone?

Some nootropics that have similar effects to Cyclazodone include Armodafinil and Modafinil. These two stimulants also promote wakefulness and cognitive function but have a lower abuse potential than Cyclazodone.

Modafinil, also known as Provigil, is a prescription medication often used to treat sleep disorders such as narcolepsy. It increases dopamine levels in the brain and has been shown to improve cognitive function in sleep-deprived individuals.

Armodafinil, also known as Nuvigil, is a more potent version of Modafinil. It also promotes wakefulness and improves cognitive function but may have longer-lasting effects and a more targeted mechanism of action.

Armodafinil and Modafinil work on the brain’s orexin and dopamine systems, while Cyclazodone works on norepinephrine and serotonin. Regarding side effects, Modafinil and Armodafinil are well-tolerated and have fewer reported side effects than Cyclazodone.

What Brain Supplements Can Cyclazodone Be Stacked With?

Cyclazodone can be stacked with various brain supplements, but it’s important to consider the potential interactions and side effects. One supplement that stacks well with Cyclazodone is Noopept.

Noopept is a powerful nootropic that enhances cognitive function and has neuroprotective properties. It also increases levels of acetylcholine (ACh), a neurotransmitter that plays a role in memory and learning. Noopept is very similar to Piracetam, another popular nootropic, but it is much more potent and has a quicker onset of action.

Another great supplement to stack with Cyclazodone is NooCube. NooCube is a nootropic blend containing 13 brain-boosting ingredients, such as Alpha-GPC, Huperzine A, and Cat’s Claw.

NooCube also contains ingredients that support brain health and protect against oxidative stress, making it an excellent foundation for any nootropic stack. Stacking Cyclazodone with Noopept and/or NooCube can enhance its effects and support overall brain health.

You can get your hands on NooCube right here:

Frequently Asked Questions (FAQ)

Let’s take a closer look at some commonly asked questions about Cyclazodone.

How Long Does It Take For Cyclazodone To Work?

Cyclazodone works within 20-60 minutes. It can take up to 8 hours for it to wear off, so it’s important to plan accordingly and avoid taking it too late in the day.

How Does Cyclazodone Make You Feel?

Cyclazodone makes you feel more alert and focused, with increased energy levels. It can also elevate mood and improve cognitive function. High doses can cause a euphoric feeling and increase sociability and confidence.

What’s The Half-Life Of Cyclazodone?

The half-life of Cyclazodone is approximately 4-6 hours. This means that it takes about 4-6 hours for the body to eliminate half of the drug from the system.

Is It Safe To Use Cyclazodone?

Cyclazodone’s safety in humans has not yet been studied. It is currently not approved for medical use and has a high potential for abuse and addiction. Cyclazodone is likely to possess hepatotoxic (liver-toxic) properties and may cause various side effects, especially at high doses. It should be used with caution and under the guidance of a healthcare professional.

Is Cyclazodone A Controlled Substance?

Cyclazodone, being an analogue of the Schedule IV controlled substance Pemoline in the US, may fall under 21 U.S.C. §813 Federal Analogue Act. This means that it could potentially be considered a controlled substance, and possession or distribution may result in legal consequences.

Can Cyclazodone Be Detected In A Drug Test?

There is currently no information available on whether Cyclazodone can be detected in drug tests. However, it is structurally similar to Pemoline, which has been reported to potentially cause false positive results for amphetamines in some drug screens.

Can Cyclazodone Be Used for ADHD?

There is limited research on the use of Cyclazodone for treating ADHD symptoms, and it is not approved by the FDA for this indication. It may have similar effects to stimulant medications used for ADHD, but more studies are needed to determine its safety and efficacy in this population.

Can I Drink Alcohol While Taking Cyclazodone?

It is not recommended to consume alcohol while taking Cyclazodone or any other stimulant medication. Alcohol can increase the effects of stimulants, leading to increased risk of harm such as elevated heart rate and blood pressure.

Can Cyclazodone Cause Weight Loss?

It is possible that Cyclazodone may have an effect on weight, as it has been shown to increase metabolism and suppress appetite in animal studies. However, more research is needed to determine its potential effects on weight in humans. It should not be used solely for the purpose of weight loss, as there can be potential risks and side effects associated with its use.


So what do we know about Cyclazodone?

It is a potent nootropic that can enhance cognitive function and elevate mood, but it may also have the potential for abuse and serious side effects. Its safety in humans has not yet been studied, so it should be used with caution and under the guidance of a healthcare professional.

Biohackers stack Cyclazodone with supplements like Noopept and NooCube for enhanced effects, but it’s important to consider potential interactions and side effects. Cyclazodone may potentially be considered a controlled substance in the US, and it may cause false positive results in some drug tests.

Overall, more research is needed on this emerging nootropic compound. That being said, we do have a lot of anecdotal evidence from users, so it may be worth trying out if you are looking for a cognitive boost.

Cyclazodone: Review of Nootropic Benefits, Uses, & Side Effects 1

Do you always feel tired and unable to focus? Check out Cyclazodone, a potent derivative of the nootropic and psychostimulant compound Pemoline.

Editor's Rating:

Sources, Studies, and Scientific Research
  1. “US3609159A – 5-Phenyl-2-Cyclopropylamino-4-Oxazolinone, and Process for Making the Same.” Google Patents, Google,  ↩
  2. Miller, Gregory M. “The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.” Journal of neurochemistry vol. 116,2 (2011): 164-76. doi:10.1111/j.1471-4159.2010.07109.x ↩
  3. Bostic, J Q et al. “Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial.” Journal of child and adolescent psychopharmacology vol. 10,3 (2000): 205-16. doi:10.1089/10445460050167313 ↩
  4. “R/Nootropics – Cyclazodone!” Reddit, ↩