Dihexa: Review of Benefits, Uses, Dosage, & Side Effects

Updated on April 24, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Dihexa review

Dihexa is a novel compound that has been gaining attention in the field of medicine and neuroscience in recent years.

The peptide has been found to have powerful nootropic effects, with studies showing remarkable cognitive enhancement and neuroprotective properties.

In this article, we will delve deeper into what exactly dihexa is and how it works, its potential applications in treating cognitive impairments and neurological disorders, and the controversies surrounding its use.

What is Dihexa?

Dihexa, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide derived from angiotensin IV that has been found to have nootropic properties.(1) It has a high affinity for hepatocyte growth factor (HGF) and its receptor c-Met, which are important for brain function and growth. Dihexa is a drug that is designed to enhance cognitive function, improve mental stamina, and enhance certain cognitive functions.

It is known for improving memory, information processing, and learning, and it is believed to work by promoting the growth of new brain cells and improving the function of existing ones. Dihexa has also been studied for its potential use in treating Alzheimer's disease and other neurodegenerative disorders, as well as in enhancing athletic performance.

The drug is orally active and penetrates the blood-brain barrier, making it a promising candidate for further research on its potential benefits for brain health. While it is a relatively new drug, Dihexa has already shown promising results in animal models, and could hold great potential for improving cognitive function in humans.

Nootropic Benefits of Dihexa

Dihexa is a promising nootropic drug that offers several cognitive benefits. Its neuroprotective properties can improve cognition and increase spines/synapses in rat models of cognitive dysfunction. For humans, Dihexa has the potential to enhance memory retention, improve information processing, and increase mental stamina. In addition to its potential use as a treatment for Alzheimer's disease and other neurodegenerative disorders, Dihexa may also be useful in enhancing athletic performance.

Enhancement of Memory and Cognitive Function

Enhancement of memory and cognitive function is one of the most significant nootropic benefits of Dihexa. The first-in-class compound is orally active and penetrates the blood-brain barrier to facilitate memory consolidation and retrieval. Animal trials have shown that Dihexa improves cognitive function in rats with Alzheimer's disease-like mental impairment.

Moreover, dihexa treatment enhances information processing, learning ability, and neural regeneration, promoting higher learning and memory. Dihexa has the potential to be used in the treatment of various neurodegenerative disorders, including Alzheimer's disease. It could also be used to enhance athletic performance by improving cognitive function and reaction time. However, more studies are necessary to determine the optimal dosage and long-term safety of Dihexa.

Improved Information Processing and Learning

Dihexa, a potent nootropic drug, has been shown to enhance certain cognitive functions, including improved information processing and learning. By promoting higher learning and memory, Dihexa can help individuals process information more efficiently and effectively.

Research has demonstrated that Dihexa can boost cognitive levels and memory in rats, and modafinil, another cognitive enhancer, has been found to improve target sensitivity in a rapid visual information processing task.

Mechanism of Action

The mechanism of action for Dihexa lies in its ability to increase the levels of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), and facilitate the activation of the HGF/MET signaling pathway. This leads to the stimulation of dendritic arborization and synaptogenesis, which helps improve cognitive function and memory retention.

Furthermore, Dihexa has been shown to activate the PI3K/AKT signaling pathway, which is known to play a vital role in synaptic plasticity and neuronal survival. These activations promote the restoration of nerve cells' structure and function, regulate inflammatory responses, and prevent nerve damage.(2) Researchers have also discovered that Dihexa attenuates cell death through an HGF-dependent signaling mechanism.

With these unique mechanisms of action, Dihexa holds promise as a cognitive enhancer and treatment for neurodegenerative disorders, such as Alzheimer's disease.

Uses of Dihexa

Dihexa has a wide range of uses, primarily focusing on enhancing cognitive function and memory. Its nootropic benefits have been demonstrated in animal models of Alzheimer's disease-like mental impairment, and it has been found to potently improve certain aspects of cognitive function. Dihexa works by penetrating the blood-brain barrier and facilitating memory consolidation and recall. Its neuroprotective benefits have also been demonstrated in rat models of cognitive dysfunction.

Improvement of Cognitive Functions with Dihexa

Dihexa has shown promise in improving cognitive functions, including memory, learning, and information processing. It is classified as a nootropic drug, which means it enhances brain performance. In animal studies, Dihexa has been found to restore spatial learning and cognitive functions, and increase synapses in rats with cognitive dysfunction.(3) It has also been shown to rescue cognitive ability in APP/PS1 mice, which are used as models of Alzheimer's disease-like mental impairment. People who have used Dihexa have reported improvements in creativity, problem-solving skills, and thinking.

Treatment for Alzheimer's Disease and Other Neurodegenerative Disorders

Dihexa has shown promising results as a potential treatment for Alzheimer's disease and other neurodegenerative disorders.(4) It works by binding to hepatocyte growth factor (HGF) with high affinity and reducing the neurological damage caused by Alzheimer's disease. Moreover, it enhances cognitive functions and increases synapses/spines in models of cognitive dysfunction. These benefits also suggest that Dihexa or similar molecules may have potential as a treatment for other neurodegenerative diseases or brain traumas.

For patients suffering from Alzheimer's disease or other neurological disorders, Dihexa could be an essential breakthrough in managing their cognitive functionalities. However, further research is still needed to establish a definitive treatment plan for these neurodegenerative disorders using Dihexa.

Potential Use in Enhancing Athletic Performance

There has been an increasing interest in the use of Dihexa as a potential cognitive enhancer for athletes. While Dihexa is primarily meant to be used in senior patients to improve cognitive functions, some may see a potential advantage in using it to enhance athletic performance. However, there is currently limited research that supports this potential use. It should be noted that the World Anti-Doping Agency has not yet included Dihexa as a banned substance, but athletes should always check with their governing organization before using any new drug or supplement.

Dihexa Dosage

When it comes to taking Dihexa, it is essential to follow the recommended dosage guidelines to ensure safety and effectiveness. As per anecdotal testimonials, the ideal dose for Dihexa ranges from 8 mg to 45 mg orally, taken once a week. Supplement companies selling Dihexa as a research chemical often suggest taking 10 to 20 mg a day, while the drug manufacturers recommend 10 mg to 20 mg once a week.

However, exact dosing may vary based on individual needs and use. It is crucial to keep in mind that Dihexa is a peptide variant derived from angiotensin IV(5) and should only be taken according to the recommended dosage. People who wish to use Dihexa for improving cognitive function, treating neurodegenerative disorders, or enhancing athletic performance, among other uses, should consult with a healthcare professional before commencing use.

Side Effects & Safety

When it comes to any supplement or drug, it is important to consider the potential side effects and safety concerns. Short term safety studies with Dihexa have shown no apparent toxicity and a lack of neoplastic induction. However, long term ingestion of Dihexa has been linked to an increased risk of certain cancers. Other reported side effects include jitters, irritability, mood swings, changes in taste, increased anxiety, nausea, and insomnia.

It should also be noted that withdrawal of Dihexa supplementation after discontinuing use can lead to jitters and irritability. While the nootropic benefits of Dihexa are extensive, users should carefully consider the potential side effects and consult with a healthcare professional before use. Overall, Dihexa seems to be safe for short term use at recommended dosages, but long term effects remain uncertain. It is important to always prioritize safety when it comes to supplementation.

Where to Buy Dihexa

PureRawz is a reputable source for purchasing high-quality Dihexa supplements. Their products are lab-tested for purity and quality, ensuring that every customer receives a reliable and effective supplement. As a USA-based company, they offer fast shipping for those who want to experience the nootropic benefits of Dihexa.

Customers can order with confidence, knowing that PureRawz only sells peptides for research purposes. This is an excellent option for individuals looking to enhance their cognitive functions, treat neurodegenerative disorders or enhance athletic performance. With PureRawz's consistent commitment to quality, Dihexa supplement buyers can be confident in the accuracy of their research results.

Dihexa FAQ

How does Dihexa work?

Dihexa functions by targeting the hepatocyte growth factor (HGF) system, encouraging synapse formation and enhancing neural connectivity, which may lead to improved cognitive abilities

What are the potential benefits of Dihexa?

Dihexa is being studied for its potential to enhance memory, increase cognitive function, and support neuroplasticity, which could be beneficial for age-related memory loss or cognitive impairments.

Is Dihexa legal?

Dihexa is not a controlled substance and is legal to purchase and possess in most countries. However, it is not approved for human consumption by the FDA or similar regulatory agencies.


In summary, Dihexa is an oligopeptide drug that shows promising results in improving cognition and memory in rat models and animal studies. It has a high binding affinity to HGF and c-Met receptors, both of which play a critical role in brain function. Dihexa may have potential uses in treating neurodegenerative disorders such as Alzheimer's disease and also enhancing athletic performance.

The drug is chemically stable and has been shown to cross the blood-brain barrier, making it an attractive option for enhancing brain function. Dihexa is classified as a nootropic drug, a substance that can help improve brain performance, particularly in the areas of learning and memory processing. Nonetheless, although Dihexa is considered safe, the possible side effects and the appropriate dosage for humans are not yet fully understood.

Further studies are needed to establish Dihexa's efficacy and to determine the optimal dosage for human use. Finally, for those looking to find Dihexa, it is important to be cautious and only purchase from reputable sources.