Dihexa: Review of Nootropic Benefits, Uses, Dosage, & Side Effects

Updated on March 2, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
Overview of Dihexa's cognitive benefits, uses, and potential side effects.

In the evolving world of nootropic and peptide therapy, the new drug Dihexa stands out as a potent compound with significant potential in enhancing cognitive function and treating neurodegenerative diseases. 

Developed by researchers from Washington State University, this oligopeptide drug, derived from angiotensin IV, has sparked considerable interest in medical and wellness communities.

By reviewing the existing research and clinical studies, we aim to provide a thorough understanding of how this peptide can be integrated into treatment methods for neurodegenerative diseases and cognitive enhancement strategies.

Are you thinking about using this nootropic? Could it offer new possibilities for patients and individuals seeking to improve their cognitive health and overall wellness?

Let’s have a closer look.

What is Dihexa?

Dihexa (also known as PNB-0408, or scientifically as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide)  is a novel and potent nootropic compound, classified as an oligopeptide. It has garnered significant attention for its potential in cognitive enhancement and the treatment of neurodegenerative diseases. Dihexa is a derivative of angiotensin IV, which is part of the renin-angiotensin system that the aldosterone hormone is also a part of.

Dihexa, a small molecule peptide, is particularly notable for its ability to penetrate the brain and facilitate the repair and growth of neurons, a critical aspect in addressing cognitive decline. Peptide Dihexa was developed by researchers to provide a treatment method for neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.

Dihexa is an oligopeptide, which means it is composed of a short chain of amino acids. This structure allows it to effectively cross the blood-brain barrier, a crucial feature for healthy brain function and neurological effectiveness.

The peptide therapy’s mechanism of action involves the potentiation of hepatocyte growth factor (HGF) and its receptor, c-Met, which plays a crucial role in synaptic plasticity and neurotrophic support. This brain-derived neurotrophic function also prevents neurological disorders from forming.

The therapeutic potential of Dihexa peptide extends beyond its neurogenic capabilities. It has been shown to improve cognitive function by enhancing memory and learning in people. This makes it a valuable therapeutic treatment in combating cognitive impairment and various brain disorders.

This nootropic drug and its ability to form new functional synapses in the brain indicates its potential to not only slow down but possibly reverse aspects of certain cognitive dysfunctions.

Pros:

  • Boosts cognitive abilities, such as improved memory formation and faster information processing
  • Stimulates the growth of new neurons, new connections, and new synapses
  • Boosts BDNF expression

Cons:

  • Not yet approved by the FDA
  • Further clinical research is needed to understand this nootropic drug’s safety profile for continued use

Mechanism of Action

Dihexa’s mechanism of action within the brain is a fascinating aspect of its pharmacological profile, particularly regarding its effects on cognitive enhancement and potential treatment of neurodegenerative diseases. 

Here’s an in-depth look at how Dihexa works within the human body:

  • Primary Mechanism: Dihexa functions primarily by modulating the activity of hepatocyte growth factor (HGF) and its receptor, c-Met. HGF is a key nerve growth factor involved in various cellular processes, including those within the body, such as the nervous system.
  • Enhancement of Neurogenesis: By enhancing the HGF-c-Met pathway, Dihexa promotes neurogenesis — the growth and development of new neurons. This signal is crucial for maintaining and improving brain function, especially in conditions where neuronal loss or damage is prevalent.
  • Formation of New Synapses: Dihexa is known for its ability to stimulate synaptogenesis — the formation of new synapses in the brain. This contributes to enhanced neural connectivity and plasticity, essential for learning, memory, and overall cognitive functioning.(1)
  • Neural Network Enhancement: Improved synaptic formation and plasticity lead to stronger and more efficient neural networks, which are vital for cognitive processes and neural health.(2)
  • Protection Against Neuronal Damage: Dihexa’s mechanism of action suggests that it may also have neuroprotective effects, helping to safeguard neurons from various forms of damage or degeneration.

While the initial research on Dihexa’s mechanism is promising, ongoing studies are crucial to fully understand the full effects of Dihexa and its potential applications in different neurological conditions, such as Alzheimer’s disease.

Nootropic Benefits of Dihexa

Let’s have a look at the key benefits of Dihexa.

1. Enhancement of Memory and Learning

Dihexa has shown significant potential in improving memory and learning abilities. This is particularly relevant for both healthy individuals seeking cognitive enhancement and patients with cognitive impairments.

2. Promotion of Neurogenesis

By stimulating the growth of new neurons (neurogenesis), Dihexa contributes to the overall health and functionality of the brain, which is crucial for cognitive processes.(3)

3. Facilitation of Synaptogenesis

Dihexa aids in the formation of new synapses (synaptogenesis), enhancing neural connectivity and plasticity. This is key to learning new information and forming memories.(4)

4. Improvement of Cognitive Function in Neurodegenerative Diseases

In conditions like Alzheimer’s and Parkinson’s disease, Dihexa’s ability to promote neuron and synapse growth offers potential therapeutic benefits in the prevention of cognitive decline.(5)

5. Enhanced Mental Clarity and Focus

Users may experience improved mental clarity and focus, beneficial for tasks requiring sustained cognitive effort.

6. Potential in Treating Learning Disorders

There is potential for Dihexa to be beneficial for people treating specific learning disorders, such as attention deficit disorder, although this application requires more research.

7. Support in Brain Repair and Recovery

In cases of brain injury or certain neurological conditions, Dihexa’s role in promoting neuronal growth and connectivity might aid in recovery and rehabilitation after memory loss.

Uses of Dihexa

Dihexa, as a potent nootropic compound, offers a range of cognitive-enhancing benefits. Its unique impact on neurology and its ability to modulate neurogenesis and synaptogenesis positions it as a promising agent in the realm of cognitive health.

Below is an overview of the nootropic benefits of Dihexa:

  1. Enhancement of Memory and Learning: Dihexa has shown significant potential in improving memory and learning abilities. This is particularly relevant for both healthy individuals seeking cognitive enhancement and patients with cognitive impairments.
  2. Promotion of Neurogenesis: By stimulating the growth of new neurons (neurogenesis), Dihexa stimulates the activation and functionality of the brain, which is crucial for cognitive processes.
  3. ALS Treatment Potential: ALS (amyotrophic lateral sclerosis) is a neurodegenerative disease that affects nerve cells in the brain and spinal cord, leading to loss of muscle control. Given Dihexa’s potential to promote neural growth and synaptic formation and retention, it presents an intriguing possibility for research in the context of overcoming ALS.
  4. Facilitation of Synaptogenesis: Dihexa aids in the formation of new synapses (synaptogenesis), enhancing neural connectivity and plasticity. This is key to brain health and facilitates the brain’s ability to learn new information and form memories.
  5. Improvement of Cognitive Function in Neurodegenerative Diseases: In conditions like Alzheimer’s and Parkinson’s disease, Dihexa’s ability to promote neuron and synapse growth offers potential therapeutic benefits in slowing or possibly reversing cognitive decline within brain cells.
  6. Neuroprotective Properties: Dihexa may offer neuroprotective effects, potentially safeguarding the brain from degeneration and damage, which is important in maintaining cognitive abilities over time.
  7. Potential in Treating Cognitive Impairment: For individuals with cognitive impairments due to various causes, Dihexa offers a potential treatment method to improve or restore cognitive functions.
  8. Enhanced Mental Clarity and Focus: Users experience improved mental clarity and focus, beneficial for tasks requiring sustained cognitive effort.
  9. Reduction in Cognitive Decline Associated with Aging: As a nootropic, Dihexa could play a role in mitigating age-related cognitive decline, helping maintain cognitive functions in the aging population.
  10. Treating Learning Disorders: There is potential for Dihexa to be beneficial in treating specific learning disorders, although this application requires more research.
  11. Support in Brain Repair and Recovery: In cases of brain injury or certain neurological conditions, Dihexa’s role in promoting neuronal growth and connectivity might aid in recovery and rehabilitation.

Where to Buy Dihexa

Are you on the search to find the best place to purchase high-quality Dihexa?

Well, your search has ended. After in-depth research and testing, we have found the no.1 retailer for Dihexa online.

Each nootropic product has third-party testing to ensure efficacy, and you’re given a money-back guarantee to ensure your satisfaction!

Dihexa Dosage

Dihexa dosages can vary widely depending on the individual’s specific needs, health status, and the condition being treated.

Overall, a standard dosage is between 5 mg to 20 mg.

Dihexa can be taken orally, and the dosage might be adjusted based on the method of administration and individual absorption rates.

It is essential to consult with a healthcare professional before starting Dihexa, as they can provide personalized dosage recommendations based on medical history and health objectives.

Clinical trials and research studies are needed to establish standardized dosing regimens for Dihexa. Such studies would also provide more information on its long-term safety and efficacy.

Dihexa Side Effects & Safety

There is limited clinical data available on the side effects of Dihexa, as it is still under research and not widely used in clinical settings. Side effects can vary among individuals, and some may experience none.

However, some potential side effects include: 

  • Nausea
  • Irritability
  • Allergic responses
  • Digestive discomfort

Safety profile notes include:

  • Research Stage: Dihexa is still in the research stage, and more extensive clinical trials are needed to establish a comprehensive safety profile.
  • Approval and Availability: The regulatory approval and availability of Dihexa may vary by country. In many regions, it might not be approved for clinical use and could be available only for research purposes.

Summary

In the landscape of nootropic and peptide therapies, Dihexa emerges as a compound with remarkable potential, particularly in the realm of cognitive enhancement and the treatment of neurodegenerative diseases.

Originating from research at Washington State University and derived from the angiotensin IV pathway, Dihexa stands out for its ability to influence neurogenesis and synaptogenesis, offering hope for both cognitive improvement and neurological recovery.

Remember to consult a doctor before using Dihexa to ensure you’re on the best track!

FAQs

How long does Dihexa take to work?

Most users notice an increase in mental clarity and focus within a few days of starting Dihexa. The effects build up as the compound reaches steady levels in the system. However, individual experiences can vary.

What is the elimination half-life of Dihexa?

The half-life of Dihexa is quite long, with 50% of the peptide drug out of your system in 12.8 days after it has been administered.

Should you cycle Dihexa?

Regular users often take breaks or cycle their usage. This helps maintain the drug’s effectiveness and reduce potential side effects. Consult a healthcare professional before starting or cycling Dihexa.

Can I stack Dihexa with other nootropics?

Yes, stacking is possible. But caution is key. Ensure compatibility with other supplements. Start with lower doses when stacking. Monitor your body’s response closely.

How should I store Dihexa?

Keep Dihexa in a cool, dry place away from direct sunlight. Always follow medical advice on dosing, which may vary based on individual health needs.


Sources, Studies, and Scientific Research
  1. Wright, John W, and Joseph W Harding. “The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer’s Disease.” Journal of Alzheimer’s disease : JAD vol. 45,4 (2015): 985-1000. doi:10.3233/JAD-142814 
  2. Weiss, Jessica B et al. “Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.” Annals of medicine and surgery (2012) vol. 71 102917. 8 Oct. 2021, doi:10.1016/j.amsu.2021.102917 
  3. Sun, Xiaojin et al. “AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.” Brain sciences vol. 11,11 1487. 11 Nov. 2021, doi:10.3390/brainsci11111487 
  4. Musazzi, L et al. “Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation.” The international journal of neuropsychopharmacology vol. 17,5 (2014): 779-91. doi:10.1017/S1461145713001685 
  5. McCoy, Alene T et al. “Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents.” The Journal of pharmacology and experimental therapeutics vol. 344,1 (2013): 141-54. doi:10.1124/jpet.112.199497 
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