Flmodafinil Review: Nootropic Benefits, Dosage, & Side Effects

Updated on January 16, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

This review will examine Flmodafinil's nootropic features, benefits, and side effects. We will also discuss the appropriate dosage and how Flmodafinil can be used to improve cognitive function.

Flmodafinil, also known as CRL-40,940, NLS-4, Bisfluoromodafinil, and Lauflumide, is a potent analog of Modafinil in the class of eugeroic drugs. It enhances wakefulness, improves focus and concentration, and increases mental energy.

But what exactly sets Flmodafinil apart from traditional Modafinil? And how can you use this popular cognitive enhancer safely and effectively?

Let's take a closer look.

Flmodafinil Review Summary

Flmodafinil is a potent analog of Modafinil, providing similar nootropic benefits such as improved focus and wakefulness. However, it has a longer duration of action and a higher potency than traditional Modafinil.

Flmodafinil is a weak dopamine reuptake inhibitor and a selective dopamine-releasing agent, which helps enhance cognitive function without causing overstimulation. However, the clinical research on Flmodafinil is limited and should be used cautiously.

Pros:

  • Longer duration of action than Modafinil
  • Enhanced cognitive function without overstimulation
  • Improves mood and motivation

Cons:

  • Limited clinical research available
  • Difficult to find high-quality Flmodafinil online

What Is Flmodafinil?

flmodafinil CRL-40,940 structure

Flmodafinil is the bisfluoro analog of the popular nootropic drug Modafinil [1]. An analog means it has a slightly different chemical structure but ultimately produces similar effects. Flmodafinil is a eugeroic smart drug and a weak dopamine reuptake inhibitor [2].

Eugeroic drugs promote wakefulness and are commonly used to treat sleep disorders like narcolepsy. A dopamine reuptake inhibitor means that Flmodafinil also improves mood, motivation, and focus by increasing dopamine levels in the brain.

Flmodafinil has a higher bioavailability than Modafinil, meaning it has a more efficient absorption and delivery in the body, thus requiring a lower dosage. It was first patented in 2013 by NLS Pharmaceutics, and the pre-clinical trials have been underway since 2015 [3].

That said, Flmodafinil is not yet FDA-approved for any medical uses and remains primarily available as a research chemical.

flmodafinil review

How Does Flmodafinil Work In The Brain?

Flmodafinil works primarily as a wakefulness-promoting agent, but it also enhances focus, improves mood, and boosts mental energy.

It does this by increasing histamine levels in the hypothalamus, a brain region responsible for regulating sleep, wakefulness, and appetite. Flmodafinil also increases levels of glutamate, one of the brain’s primary neurotransmitters involved in learning and memory. When glutamate levels are enhanced, cognitive function is improved [4].

In addition, Flmodafinil is a weak dopamine reuptake inhibitor, which means it increases dopamine levels in the brain. Dopamine is involved in the reward and pleasure centers of the brain, making it a key player in motivation and focus.

Like Modafinil, Flmodafinil also increases levels of norepinephrine (NE), a neurotransmitter involved in attention and alertness [5]. An interesting difference, however, is that Flmodafinil does not cause rebound hypersomnolence, according to Luca, Gianina, et al. Unlike Modafinil, Flmodafinil appears to need less recovery time after taking it, as evidenced by the sleep patterns it produces.

This makes Flmodafinil a promising alternative for those seeking improved wakefulness and cognitive function without needing prolonged recovery time.

What Is Flmodafinil Used For?

Flmodafinil has shown promising results in pre-clinical trials for treating sleep disorders such as narcolepsy and shift work sleep disorder. According to Luca, Gianina et al.’s study, Flmodafinil was more effective at promoting wakefulness and reducing sleepiness than Modafinil.

Flmodafinil is also used off-label as a cognitive enhancer and productivity aid by biohackers, students, and professionals. Its effects on focus, mood, and energy make it a popular choice for improving mental performance during high-pressure situations or creative problem-solving.

Anecdotally, many users report that the effects of Flmodafinil are more noticeable and longer-lasting than those of Modafinil. It may also have fewer side effects, such as jitteriness or headaches.

What Are The Benefits Of Flmodafinil For Cognition?

As a wakefulness-promoting agent and cognitive enhancer, Flmodafinil offers a range of potential benefits for mental performance. These include:

  • Improved focus and wakefulness
  • Enhanced mood
  • Increased motivation
  • Heightened alertness
  • Better memory and learning abilities

One of the strengths of Flmodafinil is its lack of rebound hypersomnolence, meaning users will not need as much recovery time after taking it compared to Modafinil or Adderall.

Another benefit is that it has a higher bioavailability and requires a lower dosage, making it more efficient in its effects.

Where To Buy Flmodafinil Online?

Flmodafinil is a research chemical and has not yet been approved by the FDA for medical use. As a result, it can be difficult to find reputable sources for purchasing it online. We couldn't find any sources that we can confidently recommend.

Instead, we recommend Modafinil as a reliable alternative for promoting wakefulness and enhancing cognitive function. It is FDA-approved, readily available online from reputable vendors, and has similar effects as Flmodafinil.

If you're looking for a reliable vendor to buy Modafinil online, we highly recommend ModafiniXL:

What Do People Say About Flmodafinil On Reddit?

Let's take a look at what people are saying about Flmodafinil on Reddit.

According to tmj87:

"...Overall, comparing Flmodafinil to Modafinil, from my experience it is way superior. No headaches, no mood swings, and only need really small doses to get full focus.

Word of caution though, do your research in where you decide to buy it first. I made that mistake!"

According to Johnjames1987:

“...It's said Flmodafinil is x4 more potent than modafinil. I really can feel the difference and take a maximum of 50-75mg each time."

According to janismm88:

"I have been using modafinil a lot even at first times when I tried it it was never so powerful as flmodafinil yes moda maybe gets you motivated etc but you are like cold robot with people. Flmodafinil powder just makes me more happy plus motivated libido is through the roof…"

How Do You Take Flmodafinil For Cognitive Enhancement?

Flmodafinil should be taken orally, with or without food. It is typically taken once a day, in the morning or early afternoon, to promote wakefulness and cognitive enhancement throughout the day.

It is important to start with a lower dosage and gradually increase it as needed to gauge individual tolerance and avoid potential side effects.

Some users choose to cycle Flmodafinil, taking it for a few weeks or months, followed by a break before starting again. This is not necessarily required but may help prevent tolerance buildup and maintain the drug's effectiveness over time.

Flmodafinil will last in the body for up to 8 hours, so it should not be taken in the evening or before bedtime as it may interfere with sleep. You can split the dosage into two smaller doses, taken in the morning and early afternoon, for more sustained effects throughout the day.

Users report experiencing positive effects at 50-200 mg dosages daily. If you haven't tried eugeroic drugs like Modafinil or Flmodafinil, starting with 50 mg daily is recommended.

Most people will find that 100 mg of Flmodafinil is the optimal daily dosage for cognitive enhancement and wakefulness. If you use other nootropics to stack with Flmodafinil, adjust the dosage accordingly to avoid potential side effects.

What Are The Side Effects Of Flmodafinil?

Since Flmodafinil works by stimulating the central nervous system, some potential side effects may include anxiety, jitters or restlessness, headaches, and insomnia.

Other common Flmodafinil side effects may include:

  • Nausea
  • Dizziness
  • Diarrhea
  • Dry mouth

Modafinil has been associated with a rare but serious skin rash called Stevens-Johnson Syndrome (SJS) [6], and it is important to seek medical attention if you experience any skin reactions while taking Flmodafinil.

It's worth noting that Modafinil has been researched extensively and has been prescribed for medical use, while Flmodafinil has not yet been studied as much and is not approved by the FDA. As a result, the potential side effects of Flmodafinil may be less well-known than Modafinil.

What Nootropics Are Similar To Flmodafinil?

Other eugeroic drugs similar to Flmodafinil include Adrafinil, Armodafinil, and Modafinil. These 3 drugs also promote wakefulness and cognitive enhancement. Let's take a closer look at each one down below:

  • Modafinil is the most widely studied and commonly used eugeroic drug but is less potent than Flmodafinil. Modafinil has a longer half-life and requires higher doses to achieve the same effects as Flmodafinil.
  • Armodafinil is the R-enantiomer of Modafinil, meaning it is a single-isomer version of Modafinil. This structure has slightly different effects and a longer action duration than both Modafinil and Flmodafinil.
  • Adrafinil is a precursor to Modafinil, which is converted into Modafinil in the liver after ingestion. Adrafinil is weaker than Modafinil, Armodafinil, and Flmodafinil. Because Adrafinil is converted into Modafinil in the liver, you'll need to take higher doses, which can strain the liver.

Modafinil is the closest alternative to Flmodafinil. It is the most well-researched nootropic in comparison and is very easy to buy online. However, if you want a stronger and longer-lasting nootropic experience, Armodafinil may be a better option.

What Brain Supplements Can Flmodafinil Be Stacked With?

Flmodafinil can be stacked with various nootropic supplements for enhanced cognitive effects. One supplement that stacks well with Flmodafinil is a choline source, such as Alpha GPC or CDP-Choline, as it can improve focus and memory formation.

One of the downsides with Flmodafinil, and Modafinil in general, is the headaches that can often occur when using them. Taking a choline supplement can help prevent or reduce these headaches.

Racetams, such as Piracetam or Aniracetam, can also be stacked with Flmodafinil for enhanced cognitive effects. Combining these two nootropics can result in improved learning and memory, increased focus, and a boost in mood.

If you don't want to experiment too much with stacking individual nootropic supplements, a well-rounded blend like NooCube can also be a good option. In addition to choline, NooCube contains various nootropic ingredients that enhance cognitive function and brain health, including Alpha GPC, Huperzine A, Bacopa Monnieri, and L-Theanine.

L-Theanine, in particular, is a great addition to a Flmodafinil stack as it can help reduce jitteriness and improve mood, creating a more balanced focus and energy. NooCube is a great foundation to stack with Flmodafinil for enhanced cognitive benefits.

You can get your hands on NooCube right here:

Frequently Asked Questions (FAQ)

Let's answer some commonly asked questions about Flmodafinil.

Is Flmodafinil legal?

Yes, Flmodafinil is legal to possess and use in the United States. It is not a controlled substance. However, it has not been approved by the FDA for medical use and, therefore, cannot be prescribed by doctors.

How Long Does It Take For Flmodafinil To Work?

Flmodafinil kicks in quickly, with effects typically noticeable within 1-2 hours of ingestion. Depending on the dosage and individual factors, the effects last for about 8-12 hours.

How Does Flmodafinil Make You Feel?

Flmodafinil makes you feel alert and focused, with improved cognitive function. It will also improve your mood and motivation levels. You will experience no crash or jitteriness.

What's The Half-Life Of Flmodafinil?

The half-life of Flmodafinil is approximately 4-6 hours, meaning it takes about 8-12 hours for the effects to wear off and the drug to be eliminated from the body.

Is Flmodafinil Addictive?

According to research and anecdotal evidence, Flmodafinil is not considered to be addictive. However, as with any drug or supplement, it's important to use caution and moderation when taking it. Also, consult a doctor if you have a history of addiction or substance abuse.

Can I Take Flmodafinil Every Day?

It is not recommended to take Flmodafinil every day for extended periods of time. This is because it can lead to tolerance and reduced effectiveness. It's best to cycle Flmodafinil, taking it only a few times per week or as needed.

Is It Safe To Use Flmodafinil?

Flmodafinil is safe when used in the 50-200 mg range and taken as directed. High doses can cause side effects such as headaches, nausea, and anxiety.

Is Flmodafinil Better Than Adderall?

Unlike Adderall, Flmodafinil is not an amphetamine and does not have the potential for abuse. It also does not cause the crash or jitteriness that Adderall can. If you're looking for a safe, non-stimulant alternative to Adderall, Flmodafinil is a good option.

Is Flmodafinil A Stimulant?

Flmodafinil is not considered a traditional stimulant like caffeine or amphetamines. Rather, it is a eugeroic, meaning it promotes wakefulness and alertness. It does not have the same potential for abuse or negative side effects as traditional stimulants do.

Can Flmodafinil Cause Weight Loss?

There is no evidence to suggest that Flmodafinil causes weight loss. However, it may indirectly lead to weight loss by improving focus and motivation, increasing physical activity, and better eating habits.

Can I Take Flmodafinil With Alcohol?

It is not recommended to mix alcohol with Flmodafinil as it can increase the risk of negative side effects and impair cognitive function. It's best to avoid consuming alcohol while taking Flmodafinil.

Can I Take Flmodafinil With Antidepressants?

Mixing Flmodafinil with antidepressants (such as Prozac) without consulting a doctor first is not recommended. This is because the combination can lead to adverse reactions or interactions. Always consult a doctor before combining any medications or supplements.

Can Flmodafinil Be Used For Treating ADHD?

Flmodafinil has not been approved by the FDA for treating ADHD, and there is limited research on its effectiveness in treating Attention Deficit Hyperactivity Disorder. It is not recommended to use Flmodafinil as a replacement for conventional ADHD medication.

Conclusion

So what do we know about Flmodafinil?

It is a eugeroic drug with cognitive enhancing effects, making it a popular choice for productivity and studying. It has a quick onset of action and long-lasting effects. However, it is not FDA-approved for medical use and should be used with caution and moderation.

Flmodafinil affects certain neurotransmitters in the brain, improving focus and alertness. It also has mood-enhancing effects and does not cause crashes or jitteriness associated with traditional stimulants.

Flmodafinil is more potent than its parent drug, Modafinil, but also has a shorter half-life. Overall, Flmodafinil is a safe and effective option for those seeking cognitive enhancement, as long as it is used responsibly and under the guidance of a doctor.

References

References
1“US20130295196A1 - Lauflumide and the Enantiomers Thereof, Method for Preparing Same and Therapeutic Uses Thereof.” Google Patents, Google, https://patents.google.com/patent/US20130295196.
2Luca, Gianina et al. “Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound.” Frontiers in neuroscience vol. 12 519. 15 Aug. 2018, doi:10.3389/fnins.2018.00519
3“Pipeline: NLS Pharmaceutics.” Monsolfoundation.ch, https://nlspharma.com/science/pipeline/.
4Ferraro, L et al. “The antinarcoleptic drug modafinil increases glutamate release in thalamic areas and hippocampus.” Neuroreport vol. 8,13 (1997): 2883-7. doi:10.1097/00001756-199709080-00016
5Gerrard, Paul, and Robert Malcolm. “Mechanisms of modafinil: A review of current research.” Neuropsychiatric disease and treatment vol. 3,3 (2007): 349-64.
6“Stevens-Johnson Syndrome.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 30 Apr. 2022, https://www.mayoclinic.org/diseases-conditions/stevens-johnson-syndrome/symptoms-causes/syc-20355936#:~:text=Stevens%2DJohnson%20syndrome%20(SJS),to%20heal%20after%20several%20days.
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