Hydrafinil Review: Benefits, Dosage, & Side Effects

In this Hydrafinil review, we look at the pros and cons of the Modafinil analogue, its recommended dosage, vendors where you can buy it, and whether its benefits outweigh the potential risks and side effects.

Finishing your day's task may be daunting at times, and your lack of focus and sluggishness may be the ones affecting your performance.

Hydrafinil promotes wakefulness and alertness.

If you are up with biohacking to stay awake and help you get through the day, then dive into this in-depth review of it.

What is Hydrafinil?

Hydrafinil (fluorenol)[1]“9H-Fluoren-9-Ol.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine, https://pubchem.ncbi.nlm.nih.gov/compound/74318. is a class of drugs called "eugeroics" which includes Modafinil, Armodafinil, Flmodafinil and Adrafinil. All these drugs provide somewhat similar results and improve wakefulness.

hydrafinil 9 fluorenol chemical structure

Hydrafinil has been found to be less stimulating than Modafinil and other eugeroics, but otherwise provides similar results. It is made up of only one active metabolite, 9-fluorenol.

Fluorenol is a weak dopamine reuptake inhibitor. Hydrafinil is 39% stronger than modafinil,[2]Dunn, Derek, et al. “Wake Promoting Agents: Search for Next Generation Modafinil, Lessons Learned: Part III.” Bioorganic & Medicinal Chemistry Letters, Pergamon, 13 Apr. 2012, … Learn more which can sometimes cause addiction in some people and has several side effects if taken in large doses or too frequently.

The shorter half-life of Hydrafinil makes it safer for people to take regularly than Modafinil.

Imagebuy hydrafinil
EffectsIncreased histamine levels, better glutamate levels, enhanced mood, less addictive and stimulating
Potential Side EffectsHeadache, dizziness, nausea, nervousness, anxiety, difficulty sleeping, mild crash
Half-Life6 - 8 hours
Common Dosage50 - 150 mg daily
Content1 g
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Eugeroics are wakefulness-promoting drugs that are beneficial when ingested in moderation. They help you maintain a state of alertness and energy and increase your productivity.

How Does Hydrafinil Work in the Brain?

Hydrafinil Review: Benefits, Dosage, & Side Effects

Research has shown that eugeroics like Hydrafinil and Modafinil keep you from sleep but with a well-rested feeling without fatigue. You become more attentive, and your information processing and logical thinking also increase.

Hydrafinil is said to improve short-term visual memory, boost focus, concentration, and information processing while reducing impulsivity and increasing critical thought.

It has serotonergic effects on neurotransmitters without worrying about getting sleep at night since the drug stays in the body for only 6 to 12 hours.

This is how Hydrafinil works:

  • Dopamine reuptake inhibition. It acts as a dopamine reuptake inhibitor that causes increased dopamine and norepinephrine levels in the prefrontal cortex of the brain.
  • 5-HT6 antagonism. The antagonism of the 5-HT6 receptor enhances the production of choline and glutamate in the brain.
  • Increased histamine levels. Hydrafinil increases histamine levels, which benefits our circadian rhythm, preventing sleepiness and narcolepsy.

What Are the Benefits of Hydrafinil?

hydrafinil benefits

Hydrafinil has favorable advantages in preventing sleep and improving mood compared to other substances. Some of them are:

1. Increased Alertness

Eugeroics like Hydrafinil can help users stay awake and alert, without the negative side effects of other stimulants and amphetamines. It is effective for staying alert without side effects. It boosts mental alertness and wakefulness because of its impact on the neurotransmitter dopamine. This may help you focus on a task at hand while not being distracted or sluggish later in the day. Additionally, people with information processing deficiencies may find that Hydrafinil helps them to better understand and remember new information.

2. Brain-Boosting Effects

Hydrafinil is a cognitive enhancer (nootropic). It is believed to increase wakefulness and vigilance. Some people also claim that it can increase the amount of dopamine and norepinephrine in the brain. This may provide a noticeable energy boost, which is less significant than modafinil and armodafinil. Learning new information becomes easier while taking hydrafinil due to increased dopamine and norepinephrine levels.

3. Mood Benefits

It is no secret that a better mood can lead to greater productivity and motivation. Some people may experience a slight mood boost from taking hydrafinil due to its serotonergic effects. This means that the drug increases serotonin levels in the brain. Dopamine and norepinephrine are also increased, leading to a better overall mood and more motivation to get things done.

How Does Hydrafinil Work?

Hydrafinil is marketed by Cephalon Pharmaceuticals as a eugeroic agent. After its development, it was one of the first substances to be deemed a successor of the FDA-approved medication, Modafinil.

In addition to alertness, the nootropic compound Hydrafinil also improves cognitive performance based on its function.

What is the Recommended Dosage of Hydrafinil?

hydrafinil dose

Determining the dosage of a drug can be difficult, as there are no clinical trials to reference. However, many people have found that the most effective dosage for Hydrafinil is between 20 and 250 mg. At this dosage, users will begin to feel the euphoric effects kick in at around 100 mg with moderate effects occurring at 25 mg.

It's important to note that Hydrafinil should only be used for short bursts of productivity - not all-nighters or 12 hour work days! You'll get about five to six hours of energy from it, which is just enough to last you through the day.

Where to Buy Hydrafinil Online?

If you're looking to buy Hydrafinil online, PureRawz is the best place to do so. Not only does the vendor offer high-quality data sheets for each chemical offered, but they also include security audits to ensure quality control.

Plus, PureRawz provides quick shipping times after the purchase is made online.

What Are the Potential Side Effects of Taking Hydrafinil?

hydrafinil side effects

Hydrafinil is a powerful wakefulness-promoting agent that has been linked to a number of potential side effects. These include nausea, headaches, and dizziness. However, these side effects are rare in people who follow the recommended dosage.

The limited clinical research leaves some unanswered questions about the long-term safety of Hydrafinil.[3]GLOOM. “Hydrafinil (Fluorenol): A Modafinil Analogue with Questionable Safety.” Mental Health Daily, 24 Dec. 2015, … Learn more It is important to consult with a licensed physician before taking this drug.

What do Reddit Users Say About Hydrafinil in Reviews?

Hydrafinil is a new drug on the market that has been gaining in popularity. It is said to be a more powerful alternative to Modafinil, and many people are curious about it. In order to get a better idea of what users think about Hydrafinil, we took a look at Reddit.

Overall, the reviews are positive. People report feeling more alert and focused when taking Hydrafinil, and they appreciate that there are few negative side effects. Some individuals did not feel the effects from Hydrafinil as strongly as they hoped, but went back to using Modafinil because it was more powerful. The majority of users report minimal negative side effects such as skin irritation - which is easily manageable. All in all, users seem happy with their experience using Hydrafinil and would recommend it to others!

Here are some experiences quoted for reference:

According to HesitantPsychonaut:

"…I tried Hydrafinil for the first time yesterday in the form of one 50mg capsule. Took it about 4 am with some coffee and my daily vitamins. About 45 mins I noticed first effects. An hour in I was experiencing some pretty strong (for afinils) stimulation, which took me by surprise as I wasn't expecting much from 50mg…"

According to OneLodz:

"…Then this evening I took 60mg and then this amazing experience happened. I felt euphoric for more than an hour and just felt very calm and centered. Just this amazing feeling of calm and well being!!! Lasted for as 3-4 hours and no crash atm still…"

How Does Hydrafinil Compare to Other Similar Nootropics?

Hydrafinil is a research chemical with little research. As it has not been thoroughly studied, its use should be tested before considering it.

Hydrafinil vs. Modafinil

Hydrafinil is up to 39% more potent than Modafinil and milder in the crash phase of usage. However, human trials on Hydrafinil are limited and Modafinil studies are better understood. Modafinil is better than Hydrafinil because it has a better known efficacy and safety profile. In general, Modafinil is the best choice for those looking to buy an eugeroic.

Conclusion: Is Hydrafinil a Safe Supplement?

Hydrafinil is available in powder or capsule form and it is deemed to be relatively safe to use based on its similarity to other scientifically backed medications. However, at present, no scientific investigation has been able to determine the safety of using hydrafinil. The FDA doesn't regulate this compound so caution is required. Hydrafinil hasn't gone through human clinical trials and it's not recommended for pregnant or breastfeeding individuals.


1“9H-Fluoren-9-Ol.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine, https://pubchem.ncbi.nlm.nih.gov/compound/74318.
2Dunn, Derek, et al. “Wake Promoting Agents: Search for Next Generation Modafinil, Lessons Learned: Part III.” Bioorganic & Medicinal Chemistry Letters, Pergamon, 13 Apr. 2012, https://www.sciencedirect.com/science/article/abs/pii/S0960894X12004702.
3GLOOM. “Hydrafinil (Fluorenol): A Modafinil Analogue with Questionable Safety.” Mental Health Daily, 24 Dec. 2015, https://mentalhealthdaily.com/2015/12/23/hydrafinil-fluorenol-a-modafinil-analogue-with-questionable-safety/.