People suffering from depression and cognitive impairment often do not receive the desired effect of their medication compared to NSI-189.
MDD or major depressive disorder is a severe medical illness that may cause mortality and functional impairment.
To prevent this, NSI-189 is developed as a novel drug that would facilitate its treatment.
What’s in it? Let’s dive in and find out.
What is NSI-189?
NSI-189 [R] is an experimental neurogenic compound that may potentially treat MDD, traumatic brain injury, stroke, cognitive impairment, and neurodegeneration due to aging.
Neuralstem Inc is a biopharmaceutical company that develops NSI-189. The chemical is being investigated as an alternative drug designed for those who failed to respond to conventional medications.
However, the phase 2 trials were not as successful as phase I. It failed to meet the requirements for the primary effectiveness endpoint in MDD [R].
At present, NSI189 is still being tested for other conditions such as improved cognition, diabetic neuropathy, stroke, and Angelman syndrome.
The study covered patient recruitment and NSI imaging.
It increases the hippocampal volume like other antidepressants. But what sets it apart is its ability to screen for compounds responsible for the said increase among rodents.
Since there is yet a need for a human clinical trial, its ability to increase the hippocampal volume makes it a better medication for depression.
Mechanism of Action
NSI-189 may promote neurogenesis in the hippocampus-derived neural stem cell and affect the parts responsible for learning, memory, and emotion. This happens along with different processes.
The drug is a benzylpiperazine-aminopyridine that may pass the blood-brain barrier.
Neurogenesis is stimulated in the hippocampal slices, specifically the left side of the human brain.
In some cases, as in after stroke, it may increase Ki67 and MAP2. It also aids in the improvement of BDNF, GDNF, and VEGF.
Noted activities are likewise seen on the Skp, Cullin, F-box containing complex.
Possible Other Mechanisms
NSI-189 demonstrates a few more mechanisms that may prove it as a better treatment for depression.
In the brain, it is said to increase the hippocampal size by 20%, and it modulates aldosterone receptors by improving glucocorticoid resistance.
Other possible mechanisms include TRPV1 antagonist and norepinephrine-dopamine reuptake inhibitor with binding affinity.
Benefits & Effects
A sufficient human clinical trial has to be conducted to prove the efficacy of this nootropic.
But since there is a lack of it, this NSI 189 review lays down the benefits of taking the product from the first trials.
On Human Studies
- Improved depression. In a placebo-controlled study, taking 40 mg to 80 mg per day of NSI 189 for 28 days showed significant improvements to depression symptoms in several people.
- Improved cognition. Self-reported improvements on cognition were reported by those who were under the phase I trial. This includes not only memory but also learning ability and focus.
On Animal Studies
The supplement revealed more effects that are favorable to humans.
- Ischemic stroke. A study on rats resulted in an improved brain and motor deficits after an induced stroke. NSI-189 reverses cell death that is caused by oxygen deprivation. The effect lasted 24 weeks.
- Diabetic neuropathy. A person with diabetes may have neuropathy, which is a form of nerve damage. To help regenerate the nerve, NSI-189 aids in the growth of neurons and stops further damage to the brain and limbs.
- Angelman syndrome. The nervous system is the most affected part of the body because of Angelman syndrome. It is a genetic disorder that causes cognitive and motor skill impairments. NSI 189 activates TrkB and Akt pathways and reverses such impairments.
Dosage & How to Take
NSI supplements should be taken in recommended amounts for visible results. A dose of 40 mg is typically advised for starters.
Depending on the body’s reaction, it can be taken once, twice, or thrice a day for 28 days, as suggested by a clinical trial focused on the treatment of the major depressive disorder.
If you wish to try the drug along with other supplements or have any existing conditions, it is best to seek medical advice to avoid adverse reactions.
Most of the clinical research on NSI 189 is on animals, and there are only very few on humans.
Nonetheless, patients’ side effects are reported regardless of taking it in small or higher doses.
People who use the drug at 40 mg may still experience dry mouth, restlessness, sleepiness, headaches, dizziness, rash, hyperthermia, and palpitations.
There are no serious long term side effects reported on animals when administered in high doses.
Even with the lack of a sufficient human clinical trial, the phosphate compound had become available in the market for human consumption.
Here is what users experience from taking NSI 189.
According to elasticoder:
“I've been using it for a month in conjunction with a consistent exercising routine and vitamins. I must say that the results are amazing. I mix 40 mg in coffee or orange juice every morning. You will feel the effects within 15 minutes. At first, you will feel stimulated and motivated. The feeling is similar to Adderall but less intense and healthier...The best part about NSI-189 is that there is no withdrawal if you stop taking it at any point. Last but not least, this compound is very hard to find. I managed to find a legit vendor with authentic signed lab reports. You can check out their site ->https://science.bio/.”
According to falre1028us:
“Personally, I've found NSI-189 to be very useful. I'm taking 50mg freebase once daily in the morning. The acute effects for me are a gentle wave of calmness, improved long-term memory, and notably improved vision.”
According to ThechanceW:
“So I started taking NSI-189 a little bit over a month ago, freebase, sourced from science.bio...The first day I took 40mg sublingually in the morning, to very little effect… The second and third days I did the same, with no effects. The fourth day I swallowed down 40mg with water, and noticed a slight mood boost. The fifth, and all subsequent days, I've taken between 80 and 110mg orally in the morning, sometimes on an empty stomach, sometimes not, and I feel as though I've been brought back to life.”
NSI-189 Freebase vs. Phosphate Powder: What's the Difference?
There are instances when both freebase and phosphate are available, and users get confused about which one to get.
Both forms provide the same benefits in improving depressive symptoms while showing better cognitive function.
To add some clarity, here is what you should know about their difference.
Phosphate is the one used by Neuralstem Inc in their clinical trials. It is best taken orally and is about 15 to 20% more expensive than the other version, but is much more stable and has better bioavailability.
The freebase version is used for sublingual ROA. It is the secondary amine, which is the nitrogen atom bonded to two carbon atoms and one hydrogen atom. It has poor bioavailability.
If you consider purchasing NSI 189, you may want to consider the mentioned factors to know whether to get the freebase or the phosphate.
Where to Buy NSI-189 Phosphate Powder?
It is challenging to find NSI 189 for sale due to its scarcity. If there is availability in the market, there are still pertinent things you have to check to ensure that your chosen vendor is reliable and that what you are buying is legitimate.
Some supplements are priced very high, while some are too low. To avoid any problems with NSI-189 buy from reliable sources and check the following:
- Credentials. The vendor has evidence of independent laboratory testing.
- Trustworthiness. There are hefty of good reviews about the vendor.
- Availability. There should be customer service support that would assist customer queries.
- Trusted methods. Uses organoleptic verification
Organoleptic verification is an intensive method of identifying compounds.
This method includes observing the actual appearance and physical properties of the chemical if it matches the online reports.
Often, the appearance, taste, and smell are the factors to check in organoleptic verification. The chemical may be crystalline, has a faint odor, and has a bitter taste.
NSI-189 is not very dense compared to other chemicals. 50 mg of the supplement is equivalent to 0.15cc scoop.
This dosage is often used for the treatment of patients with cognitive impairment and depressive symptoms. A clinical trial may use the 40-120 mg NSI 189 dosage.
NSI-189 is eyed as a drug for the treatment of major depressive disorder.
Even with a lack of human study, it remains a potential antidepressant medication.
Its administration also shows positive responses in the brain that may improve cognition caused by brain trauma or aging.
The phase I clinical trial gave high hopes in the medical field as to the significant discovery of a possible new treatment for depression.
However, other crucial aspects have to be covered and tested to amplify the efficacy of NSI-189 as a new strategy or treating depression and cognitive impairment.