Pyritinol Review: Benefits, Dosage, Side Effects & Where to Buy Encephabol

Cognitive decline among the elderly is a common occurrence. But based on studies, Pyritinol seems to have it handled.

Let's check out if it is true in this Pyritinol review.

What is Pyritinol (Encephabol)?

Pyritinol (also known as pyrithioxine) is a substance of two Vitamin B6 molecules joined by two sulfur atoms (a disulfide linkage). Its profile shows a long history of usage in Europe to treat dementia and other forms of cognitive decline in the elderly.

what is pyritinol

Pyritinol (pyridoxine disulfide or pyrithioxine), a sulfhydryl-containing dimer of 5-thiopyridoxine, is a sulfhydryl-containing chemical. It was used as a psychostimulant with dubious efficiency but no known side effects from 1961 onwards until mainly being abandoned.

Pyritinol has been licensed in Austria, Germany, France, Italy, Portugal, and Greece for "symptomatic treatment of chronically reduced brain function in dementia syndromes" and "supporting treatment of sequelae of craniocerebral trauma." It is also licensed in France as a disease-modifying therapy for rheumatoid arthritis, based on the findings of clinical trials. It is available over the counter in many countries and is widely advertised on the internet as a treatment for "memory problems."

It has resurfaced as a nootropic chemical for recreational use, but no research in the young adult population has been conducted.

How Does Pyritinol Work?

Pyritinol is a thiamine derivative. Thiamine is a water-soluble B vitamin that plays an important role in the metabolism of carbohydrates, fats, and proteins. Thiamine deficiency is associated with many neurological problems, including dementia.

It is a disulfide compound. It is an oxidized form of thiamine. Oxidized thiamine has been shown to enhance memory in older people.

Pyritinol is a nootropic substance that helps you think more clearly. It results in glucose reuptake in the brain and is commonly used for various cerebrovascular conditions.

Pyritinol is an effective memory enhancer. The reason for this is that it can cross the blood-brain barrier. It also increases the availability of thiamine in the brain. Pyritinol aids in the pathways regulation of neurotransmitters such as acetylcholine, GABA, N-methyl-D-aspartate, etc.

Thiamine is essential for the metabolism of carbohydrates, fats, and proteins. It is an essential nutrient that helps to produce energy in the body. Thiamine or vitamin B1 is water-soluble and a vitamin containing sulfur. It plays an important role in energy metabolism from the tricarboxylic acid cycle. Thiamine deficiency is associated with many neurological problems, including dementia.

It is a disulfide compound. It is an oxidized form of thiamine. Oxidized thiamine has been shown to enhance memory in older people.

Pyritinol is believed to act as a selective serotonin reuptake inhibitor (SSRI) by blocking the reuptake of serotonin. This is the cell chemical that helps your brain produce a feeling of calm. It can also be helpful for depression.

Benefits of Pyritinol (Encephabol)

Pyritinol, also known as pyridoxine disulfide or pyrithioxine, is a semi-synthetic water-soluble vitamin B6 (European medicinal names Encephabol, Encefabol, Cerbon 6) (Pyridoxine HCl).

pyritinol benefits

Merck Laboratories created it in 1961 by using a disulfide bridge to connect two vitamin B6 molecules (pyridoxine). It has been a prescription and over-the-counter medicine for cognitive difficulties, rheumatoid arthritis, and learning disorders in children in numerous countries since the 1970s. It has been offered as a nootropic dietary supplement in the United States since the early 1990s.

Pyritinol is used to treat Alzheimer's disease, stroke, Parkinson's disease, dementia, age-related memory loss, and traumatic brain injury. It also improves psychomotor performance.

Pyritinol is a nootropic substance that helps you think more clearly. It promotes glucose reuptake in the brain and is commonly used for various cerebrovascular conditions.

Pyritinol Experiences & Reviews Shared on Reddit

Here's what you can get from taking Pyritinol based on experiences shared on Reddit:

According to danarm:

"Yes, I have used it (Encephabol 200 mg). It is good, it feels similar to modafinil, but too much of it can give panic attacks. I prefer modafinil instead."

According to crogenroler:

"I used it regularly for over 2 years, here is my experience: Using 200 mg. tablets (Encephabol), the onset is maybe 20-30 minutes, with a notable stimulation, both mental and physical. It's kind of on the harsh side, similar to too much sulbutiamine or phenylpiracetam. I found the effect was quite noteworthy from 200-to 400 mg. It goes well with amphets, Ritalin, pemoline. It is quite good as a stand-alone, although it is somewhat harsh, not smooth, and will keep you awake. The effects are very cerebral, with a sense of pressure in the head. Intense, rough, though I would do it again (Will keep you awake-not before going to bed."

According to u/ranza:

"I should start that I just had a horrible reaction after taking 300mg of Pyritinol; about an hour after taking the drug, I've felt so tired that I needed to lay down, and I've started seeing things with my eyes closed. When I've tried to get up, I've noticed something wrong with my sense of balance, and I couldn't read anything from a short distance because it was becoming blurry. I was uncoordinated and had heart palpitations to the degree that pushed the coffee cup off the table (it had never happened to me before). It was awful, now it's about 7h after the ingestion, and I'm slowly coming back to myself. In the meantime, I've drank a lot of water, and I had to pee about 7 times."

Where to Buy Pyritinol?

Pyritinol is available from online pharmacies or even on Amazon. You can choose to purchase it from your reliable vendor. It is sold by the name of Encephabol on the Cosmic Nootropic website.

The price will depend if you are buying the liquid or tablet form plus the corresponding shipping fee depending on your location.

Pyritinol Dosage

Pyritinol helps treat cerebral and mental function disorders. Coated pills of Encephabol (Pyritinol) are available. The dosage is determined by the severity of the patient's illness. Tablets should be taken with a full glass of water and a meal.

pyritinol dosage

Adults should take 600 mg every day (2 tabs 3 times a day).

Dosage for newborn infants: 20 mg every day for a month starting on the third day of life.

Dosage for pediatric patients: 2 months: every week, the dosage is increased by 20 mg until the daily dose reaches 100 mg.

50-300 mg per day for children aged 1 to 7. 50-600 mg per day for children aged 7 and up (1-2 tabs 1-3 times a day).

Patients with chronic illnesses should receive treatment for at least 8 weeks.

How to Take Pyritinol?

A standard Pyritinol dosage is 600mg taken in divided dosages with meals throughout the day, with 300mg taken with two of the day's meals.

It is sold in tablets, and the suspension was taken by mouth. Remember to take it with food, drink a glass of water and swallow it whole, not chew or crush.

Pyritinol Side Effects & Safety

Adverse effects were reported in 25% of patients when reintroduced in some countries for rheumatoid arthritis. In the process, the apparent greater frequency of adverse reactions to Pyritinol patients with rheumatoid arthritis has been attributed to cross-allergy with d-penicillamine.

pyritinol side effects

Roughly 40% of users experience adverse reactions, with about 23% of those who do not continue using the product. The most common symptoms are non-specific rashes and stomatitis, but pemphigus, lichen planus, and photosensitivity have also been observed.

Users report that when they take Pyritinol, they experience the following side effects:

  • nausea
  • dizziness
  • headaches
  • blurred vision
  • excessive thirst
  • sleepiness
  • irritability
  • heart palpitations
  • feeling anxious
  • anxiety
  • increased blood pressure
  • increased heart rate

If you experience these side effects, stop taking Pyritinol immediately and seek medical attention.

Frequently Asked Questions (FAQ)

Let's answer your questions here.

Is Pyritinol Safe to Take with Alcohol?

For the same reason that it is not advisable to mix alcohol with any drugs, it is also not advisable to mix Pyritinol with alcohol.

Can Pyritinol Be Taken With Medications? 

Pyritinol can be taken with most medications, but you should not take it if you take other medicines containing alcohol.

What are the Warnings of Pyritinol?

Its pharmacology shows that it has adverse effects on people who have a history of rheumatoid arthritis.

Pyritinol Review: Conclusion

Pyritinol is a cholinergic nootropic medication used to treat dementia and recover damaged cognitive functions. It is now available in more than 50 countries throughout the world. It's used in medicine to treat dementia, mental impairment, and developmental delays in children, including autism.

Pyritinol is not a diet pill, nor is it a stimulant. As long as you follow the dosage guidelines, it will be safe to take. While some people report side effects, the product is considered safe.