PRL-8-53: Review of Nootropic Benefits, Dosage, & Side Effects

Updated on February 27, 2024
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)
An overview of the nootropic benefits, dosage, and side effects of PRL-8-53.

PRL-8-53, a synthetic nootropic compound developed in the 1970s, has been making waves for its potential memory-enhancing effects. This potent cognitive enhancer promises enhanced learning and subsequent retention in humans. 

The available findings suggest that PRL-8-53 could cause a slight improvement in the retention of verbal information, pointing towards its potential as an effective nootropic for improved learning.

However, with limited human trials conducted so far, the full extent of PRL-8-53’s effect on learning and retention of verbal information is yet to be fully understood. 

This article provides a comprehensive overview of PRL-8-53, delving into its chemical structure.

We will also discuss recommended dosages, safety concerns, potential side effects, and where to buy PRL-853. By considering all relevant aspects, you will be better equipped in your search for the best memory-enhancing drug in the nootropic community. 

What is PRL-8-53?

PRL-8-53 (Methyl 3-2-benzyl methyl amino ethyl benzoate hydrochloride), is a nootropic substance that was first synthesized in the 1970s by a chemist named Nikolaus Hansl at Creighton University. It works by increasing neurotransmitter activity in the brain, namely acetylcholine (ACh) and dopamine (DA).

PRL-8-53 is a synthetic nootropic used for research purposes and cognitive enhancement. PRL-8-53 is derived from benzoic acid (found in dairy products, fruits, and plants) and phenylethylamine (a stimulant chemical).

Evidence from one of the only human research studies found that PRL-8-53 causes a statistically significant degree of improvement in the brain’s retention of verbal information. There was a 42.7% increase in memory retention in 24 hours and a 45.2% increase in 1 week after using PRL-8-53.(1)

Studies on PRL-8-53 are limited, but this one clinical trial done by committed researchers has shown promising results regarding memory enhancement in healthy people over 30.


  • Improves memory and cognitive function
  • Improves learning capacity 
  • A potent nootropic with no severe side effects reported


  • Limited data available (only 1 human study conducted)
  • A niche-market nootropic that can be hard to find

Mechanism of Action

The PRL-8-53 mechanism of action works through several processes in the brain.

Let’s delve into how this powerful nootropic influences our cognitive function and mood.

  1. Modulates Brain Dopamine: PRL-8-53 modulates dopamine levels in the brain. Dopamine is a neurotransmitter that plays a significant role in mood, motivation, and reward. By influencing dopamine levels, PRL-8-53 may enhance cognitive performance and improve memory.
  2. Enhances Acetylcholine Production: PRL-8-53 might boost acetylcholine production. High levels of acetylcholine are vital for people who need to increase memory and learning capacity. Therefore, enhancement of acetylcholine activity could lead to improved short-term memory and avoidance learning.
  3. Influences Serotonin Levels: This nootropic supplement potentially affects serotonin levels in the brain. Serotonin regulates mood and stress response. As a result of low oral doses of a new psychotropic agent like PRL-8-53, there could be an improvement in motivation and a reduction in stress due to a rise of this mood-regulating neurotransmitter.
  4. Increases BDNF: It’s hypothesized that PRL-8-53 increases brain-derived neurotrophic factor (BDNF). BDNF supports the survival of existing neurons and encourages the formation of new ones. Thus, increased BDNF can counteract cognitive decline and enhance cognitive function.

Nootropic Benefits of PRL-8-53

PRL-8-53 (Methyl 3-2-benzyl methyl amino ethyl benzoate hydrochloride) is a nootropic that could potentially enhance your cognitive abilities.

Here are some of PRL-8-53’s key benefits and ways it may improve your brain function.

1. Boosts Short-Term and Long-Term Memory Performance

PRL-8-53 can potentially enhance your short-term and long-term working memory recall and reduce memory loss. Psychopharmacology studies gave this theory a test and invited healthy subjects to take PRL-8-53. It was found that verbal information was improved to a statistically significant degree after the administration.

According to Dr. Hansl et al., the benefits of taking PRL-8-53 can be broken down into 3 major categories:

  • Immediate short-term memory improvement
  • Greater long-term retention
  • Improving learning abilities

The immediate memory and learning improvement is thought to be due to PRL-8-53’s cholinergic properties.(2)

The long-term retention and increased learning ability may be due to PRL-8-53’s ability to increase dopamine levels in the brain.(3)

2. Increased Learning Ability

Through studies conducted using the serial anticipation method under double-blind conditions, it was observed that PRL-8-53 resulted in a slight improvement in the acquisition of information. 

More significantly, the retention of verbal information was found to improve to a statistically significant degree. These improvements were observed with low oral doses of the supplement. 

This increased learning ability is because of PRL-8-53’s ability to affect the cholinergic system. Oral intake of PRL-8-53 boosts your acetylcholine levels to improve your cognitive performance and allow you to take in new information. 

3. Assists with Verbal Fluency and Language Learning

Finally, PRL-8-53 may assist with verbal fluency and language learning. If you’re trying to learn a new language or improve your speaking skills, this nootropic might be beneficial.

During the double-blind placebo study conducted with human subjects (referenced previously in the article), verbal information was found to improve by a statistically significant degree.

4. Improves Focus and Concentration Levels

Concentration levels could possibly be boosted by PRL-8-53. It helps in maintaining focus on the tasks at hand, making it easier for you to stay productive throughout the day. PRL-8-53 reviews highlight this nootropic’s benefit as a study aid for students who need a cognitive boost.

Uses of PRL-8-53

PRL-8-53 powder is a synthetic research compound that has been of interest mainly for its potential nootropic effects. The primary research around PRL-8-53 is limited, and it has not been widely studied or accepted in mainstream medicine or pharmacology.

The primary uses of PRL-8-53 in research contexts, based on the available literature, include:

  1. Memory Enhancer: The most notable study on PRL-8-53, conducted by Hansl and Mead in 1978, investigated its effects on human memory. In this study, single doses of PRL-8-53 were found to improve word retention scores in healthy volunteers.
  2. Cognitive Enhancement: While detailed studies are limited, PRL-8-53 has been investigated for its broader cognitive-enhancing properties, including potential effects on learning (memory formation), focus, and information processing.

Where To Buy PRL-8-53

The best place to purchase PRL-8-53 is from a reputable nootropics vendor such as is a leading online supplier of nootropics and other synthetic compounds. They offer a wide range of products, including PRL-8 53, at competitive prices. If you spend over $100, you are also eligable for free shipping.

Their PRL-8-53 is sold in liquid form and comes in a 600 mg bottle for only $29.99. All of their products are lab-tested and third-party verified for quality and purity.

PRL-8-53 Dosage

PRL-8-53 dosage varies among different people. Anecdotal reports suggest a range between 5 mg to 20 mg per day.

  • 5 mg is often enough for beginners
  • Experienced users may opt for up to 20 mg

This range, however, isn’t backed by extensive studies with human participants.

The enhanced memory function of PRL-8-53 is usually noticed within an hour of ingestion. These memory retention and overall cognitive effects can last several hours depending on the individual and the dose taken.

For optimal absorption, it’s best to take PRL-8-53 on an empty stomach. This advice is based on user experiences from PRL-8-53 Reddit reviews rather than scientific research.

There are no official dosing guidelines for PRL-8-53 due to a lack of extensive human studies. As a result, caution should be exercised when using this substance. Always start with a low dose and gradually increase if necessary.

PRL-8-53 Side Effects & Safety

There’s a lack of extensive research on PRL-8-53, especially compared to more established nootropics and drugs.

However, here are 5 key considerations about PRL-8-53’s side effects and safety profile:

  1. Limited Data: Due to the limited number of human studies on PRL-8-53, a comprehensive profile of its side effects is not well-established. The 1978 study reported no side effects, but this information is based on a single low oral dose administration to a small group of participants.
  2. Anecdotal Reports: Some users in online communities and forums have reported various side effects, but these are anecdotal and have not been systematically studied. These reported side effects range from headaches and fatigue to changes in mood.
  3. Purity and Source Concerns: As with many unregulated compounds, the purity and source of PRL-8-53 can vary, which can introduce potential health risks or side effects not directly related to the compound itself.
  4. Long-Term Effects: There’s a lack of long-term studies on PRL-8-53, so potential chronic side effects or interactions with other drugs are unknown.
  5. Mechanism of Action: The precise mechanism of action for PRL-8-53 is not fully understood, which means unexpected side effects could potentially arise due to interactions with other biological processes.


PRL-8-53, a synthetic nootropic compound, has garnered interest in recent years for its potential cognitive-enhancing properties. Preliminary studies, particularly a 1978 investigation, hint at its capacity to improve word recall in healthy adults.

However, the limited body of scientific literature on PRL-8-53 (Methyl 3-2-benzyl methyl amino ethyl benzoate hydrochloride) emphasizes the nascent stage of our understanding.

As the pursuit of cognitive enhancement continues to captivate both the nootropic community and the scientific community, it is paramount that rigorous studies be conducted on compounds like PRL-8-53. Although it was found that PRL-8-53 causes a slight improvement in memory retention, more studies are still needed as researchers are still learning about this nootropic’s effects on the human brain.

Remember, since PRL-8-53 is a research chemical, it’s essential to consult with a healthcare professional before adding it to your wellness routine.


How long does PRL-8-53 take to work?

PRL-8-53 typically starts working within 30 minutes to an hour after ingestion. However, this can vary depending on individual metabolic rates.

What is the elimination half-life of PRL-8-53?

Not much is known about the exact PRL-8-53 half-life and how quickly the impacts on learning and on retention can be felt. This is because it hasn’t been extensively studied in humans. However, its effects are usually felt throughout the day.

Should you cycle PRL-8-53?

Due to limited data, there’s no standard recommendation for cycling PRL-8-53. However, cycling nootropics can help prevent tolerance. Always consult with a healthcare provider.

Can I stack PRL-8-53 with other nootropics?

Yes, PRL-8-53 can be stacked with other nootropics. However, it’s vital to research each stack and understand potential interactions and side effects.

How should I store PRL-8-53?

PRL-8-53 should be stored in a cool, dry place, away from direct sunlight. Also, keep it out of reach of children.

What are the potential side effects of PRL-8-53?

Possible side effects, though rare, include headache, fatigue, and nausea. If these persist or worsen, seek medical attention.

Is PRL-8-53 legal to purchase and use?

The legality of PRL-8-53 varies by country. In the U.S., it’s unregulated, so it’s legal to purchase for personal use. Always check your local regulations.

Sources, Studies, and Scientific Research
  1. Hansl, N R, and B T Mead. “PRL-8-53: enhanced learning and subsequent retention in humans as a result of low oral doses of new psychotropic agent.” Psychopharmacology vol. 56,3 (1978): 249-53. doi:10.1007/BF00432846 ↩
  2. Hasselmo, Michael E. “The role of acetylcholine in learning and memory.” Current opinion in neurobiology vol. 16,6 (2006): 710-5. doi:10.1016/j.conb.2006.09.002 ↩
  3. Abe, Mitsunari et al. “Reward improves long-term retention of a motor memory through induction of offline memory gains.” Current biology : CB vol. 21,7 (2011): 557-62. doi:10.1016/j.cub.2011.02.030 ↩