Memory decline is one of the most feared effects of aging and PRL-8-53 seems to be the answer to this dilemma.
Would you believe that in a study, it was able to improve the memory of its subjects by more than 200%?
This nootropic is promising in that aspect. But is there more to it than a memory booster?
Let us find out in this PRL-8-53 review.
What is PRL-8-53?
PRL-8-53 [R] is a synthetic nootropic derived from benzoic acid and phenylmethylamine. Benzoic acid is found in the food we eat such as dairy products, fruits, and plants.
The drug name is methyl 3-2-benzyl methyl amino ethyl benzoate. It is a promising supplement that was developed in 1972 by Dr. Nikolaus Hansl at Creighton University.
Rumors and a few documents revealed that a stronger version was also created by Dr. Hansl, PRL-8-147.
In 1978, Dr. Hansl conducted a human study where volunteers doubled their memory with just a single dose.
This discovery made it the most talked-about nootropics in the market.
Neurohackers even tagged it as a powerful supplement that boosts memory formation, retention, and recall improving the overall cognition and memory function.
As a brain supplement, methyl 3 2 benzyl exhibits changes in one’s ability to think and process information. Its chemical makeup protects the brain cells from damage and prevents it from neurological diseases.
With better cognitive function, the mental faculties for memory, alertness, attention, and intelligence work perform at their peak.
How Does it Work?
3-2-benzyl methyl amino ethyl benzoate regulates the neurotransmitters. According to Dr. Hansl, it boosts dopamine, modulates serotonin, and enhances acetylcholine activity.
Acetylcholine is a neurotransmitter that works in improving memory. On one hand, the increased dopamine levels make you focused, active, and motivated.
Serotonin handles feelings of depression, anxiety, and difficulty in sleeping. PRL853 (53*8) inhibits serotonin production to prevent such unproductive states.
In the lone research, it was expected that the volunteers will develop impulsive aggressive disorders caused by dopamine and serotonin activities. But such side effects were not prevalent among them.
Effects & Benefits
People use nootropics for improved memory and cognition. PRL-8-53 reviews revealed that its supplementation can improve mental abilities in a short period.
This supplement has only limited studies so its effects and benefits are yet to be officially published for representation. However, there is anecdotal evidence that supports this claim.
Users attest to its ability to improve memory and cognitive function. These two are the primary benefits of the product.
Let us expound on it a little more.
Long-term memory enhancement
In the only human clinical study, the participants were given a dose of 5 mg 2 hours before a memorization test.
They listened to recordings with 12 words in various sequences. Then they were asked to recall the words right after finishing the test.
Again they were asked to recall the words 2 hours and 96 hours after the test.
In these 3 instances, the immediate recall showed little benefits from taking PRL-8-53. But the later test showed an 80% improvement in the result.
Improved visual memory
The unpublished research of Dr. Hansl shows a result of a test where volunteers recalled the geometric patterns shown to them by drawing them on a piece of paper.
This test has high statistical data supporting improved visual memory after taking the supplement.
Another test result that is yet to be found is the one where participants were asked to form words using dots and letters. Those who are on PRL-8-53 have higher results giving the drug another point for its potential in verbal fluency.
There are still other potential benefits of the drug that results from various chemical actions in the brain.
The following are found in the clinical trials conducted on animals. These are assumed to also take place in the human brain.
- Upregulation of dopamine. Dopamine production slows down as we age. This process has a significant impact on our cognition. The compound modulates dopamine production to prevent age-related memory loss and cognitive decline.
- Long-term memory formation. When tested on animals, the drug increased the noradrenaline responses peripherally and centrally. If the same effect is visible in humans, there is a high possibility that it can increase storage for long-term memory.
- Boosts cholinergic system. The drug improves the acetylcholine response in the brain. It implies that it can boost the chemical system responsible for memory formation, storage, and retrieval.
Dosage & How to Take
The use of it has limited clinical trials that can establish the proper dose.
What is readily available is the quantity that exhibits its known benefits among users. The published study recommends taking 5 mg. Depending on the effects, the users increase their dosage to 10-20 mg per day.
There is an ideal PRL-8-53 dosage in the patent information. The ratio of the dosage to the bodyweight is .1-4mg/kg. This ratio is quite controversial as it provides a wide window of dosage variance.
Taking the drug in its maximum dose shows no evidence of danger. However, in animal tests, it was proven lethal.
The powder supplement may be administered in other ways but Dr. Hansl’s team recommends oral dosage.
When you buy PRL-8-53, it is often available in 1 to 5-gram powder jars. It can be simply swallowed, added to a drink, or in caps.
PRL-8-53 is a well-tolerated nootropic and poses no serious side effects based on the limited clinical trial.
If it should have any, it is expected to have similar side effects with other nootropics.
Users may experience a mild headache while using the drug other than that, there is nothing else reported.
In an animal study, high doses may reduce motor function. This is yet to be further studied on humans.
To avoid adverse effects, you should start with small doses and work your way up to taking higher doses depending on how your body responds to it.
Here are a few PRL-8-53 Reddit experiences.
According to inmy325xy:
“I started out with small doses and worked my way up to larger quantities. I definitely feel that 10mg is a great everyday dose and it didn't seem like taking 15mg was a big improvement over the 10. However, I decided to try 20mg on Friday for my Neuroscience test and was amazed by the enhancement in recall I had.”
According to baliflipper:
“I’ve noticed increased verbal fluency with PRL myself. Paired with caffeine it’s a great study too. But like mentioned, it has to be taken with studying and when taking the exam for recall.”
According to wave78:
“I used PRL with Semax and some caffeine and I memorized about 300 questions for an exam in like 3 hours. That combo was amazing for memory. I have a horrible memory by the way. I'm not young drank heavy most of my life too. If you know me memory is not my thing. I save it for those occasions.”
Read more about the research and how to buy PRL in this review.
Nootropics work in synergy. Each of them has a benefit of their own and stacking them accurately poses positive reactions to the body.
Although we have little research and understanding about the benefits and works of PRL-8-53, we can still rely on the idea that the stacked supplements give maximum benefits when taken together.
Based on anecdotal evidence, a stack may work well with the following:
- Vitamin B12
- Alpha GPC
The mentioned supplements are tested only by the users and not based on research. There is no solid evidence that these substances are safe to interact with PRL-8-53.
Where to Buy PRL-8-53 Powder and Capsules?
Experimental drugs should be bought from trusted vendors. It is unregulated and any vendor can simply claim the authenticity of their products.
Reputable nootropic vendors like Science.bio offer lab-tested supplements so customers are assured of its purity and identity.
PRL-8-53 powder is available in half, 1, and 5-gram jars.
Frequently Asked Questions (FAQ)
This chemical has little research but we can still answer basic questions that might have crossed your mind.
What is the Half-Life of PRL-8-53?
Users have shared that they are experiencing effects 30 minutes after taking the drug.
It remains in the body for 2-4 hours. Others suggest to take it 30 minutes before your target activity.
How Much is PRL-8-53?
Science.bio sells PRL-8-53 solution for $29.99. If buying in bulk, you can get it as low as $20.99.
The powder form is available in 500 mg jar. It costs $14.99 per jar and only $10.49 in bulk.
PRL-8-53 is created in the laboratory that aims to target memory and cognitive function. Despite the little research about its potential benefits, it has multiplied its supporters because of its cognitive effects.
More strong evidence may be needed to prove that it is worthy in the nootropic community. But as long as it is unregulated with no recorded toxicity for long-term use, it will continue to be considered as one of the best cognitive enhancer supplements.