Unifiram Review: Benefits, Side Effects, Dosage & Where to Buy

If you are interested in learning about Unifiram, then this article is for you. In this Unifiram review, we'll cover the benefits of this nootropic, what its side effects are, and how to take it.

What is Unifiram?

unifiram structure

Unifiram (DM-232)[1]“Unifiram.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine, https://pubchem.ncbi.nlm.nih.gov/compound/9861054. is a nootropic research chemical with better antiamnesic potency than piracetam in animal trials. Sunifiram (DM-235) and sapunifiram (MN-19). Dextro Unifiram is the more active of the two enantiomers. It alleviates pentobarbital-induced hypnosis while having no effect on motor coordination. As of today, no human studies on unifiram have been conducted. Unifiram is not patented and is available for purchase online despite a lack of human and long-term toxicity research.

Imagebuy unifiram
EffectsImproves concentration, memory, learning, mental energy, and basic cognition
Potential Side EffectsIrritability and anxiety (higher doses)
Half-Life3 - 5 hours
Common Dosage5 - 10 mg daily
Content1 g
Money Back GuaranteeCase-by-case
Rating⭐⭐⭐⭐☆ 4.3/5
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Unifiram and sunifiram were tested at key receptors, ion channels, and transporters but showed no affinity for any of them. At 1 μM, they didn't bind glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, or opioid receptors.[2]Scapecchi, Serena, et al. “Structure–Activity Relationship Studies on UNIFIRAM (DM232) and Sunifiram (DM235), Two Novel and Potent Cognition Enhancing Drugs.” Bioorganic & Medicinal … Learn more The medications didn't potentiate recombinant AMPA receptors, demonstrating they aren't positive allosteric modulators. In the passive avoidance test, they prevented amnesia induced by the AMPA receptor antagonist NBQX, suggesting indirect or downstream AMPA receptor activation may be involved in their memory-enhancing effects.

How Does Unifiram Work?

Although the mechanism of action of unifiram is still being investigated, it appears to counteract the over-stimulating effect of other nootropics, conferring anti-fatigue and cognition-enhancing properties. It can also be combined with cholinergic nootropics and racetams.

What are the Benefits of Unifiram?

Unifiram functions as an AMPA and NMDA receptor agonist, reducing the effects of these neurotransmitters. Memory and cognition are known to be improved by compounds with a similar mechanism of action as Unifiram. They have anti-amnesic, anti-sedative, and anti-hypnotic properties, in addition to cognitive benefits. Unifiram's benefits include increased synaptic transmission and acetylcholine production. It is also useful in reducing the amnesic effects of scopolamine and improving memory according to studies in mice.

unifiram review

Consuming Unifiram improves focus, memory, learning, mental vigor, and fundamental cognition, according to numerous anecdotal reports. These are the same results as well-known Racetams like Piracetam and Aniracetam. The difference is that Unifiram appears to be far more effective, producing greater effects at lower doses.

According to the evidence, it appears to increase glutamate and acetylcholine levels in the brain. Increased levels of these brain chemicals result in brain neurons that transfer impulses more efficiently.

As a result, your ability to process information more quickly and clearly improves. That is why it is a popular choice for anti-amnesiac effects such as increased attention span and mental clarity.

Customers claim that, unlike many Racetam nootropics, this chemical is ineffective as a mood enhancer for anxiety or depression treatment. There is also no evidence that it can improve physical performance.

Anecdotal evidence suggests that it functions as a nootropic, improving cognitive clarity, concentration, speed of thought, and confidence.

What's the Dosage of Unifiram?

There is no official Unifiram dosage guideline because the drug is unregulated and there are no human studies. Anecdotal reports suggest that a 5-10 milligram (mg) dose is sufficient to provide powerful results due to the supplement's strength. Many users also recommend not exceeding 30 mg.

People report experiencing unwanted side effects at higher doses, such as out-of-control feelings and prolonged comedowns. To avoid such occurrences, limit your dose to no more than 10 mg. To avoid developing a tolerance, take the supplement in cycles rather than continuously.

What are the Side Effects of Unifiram?

According to anecdotal evidence, the chances of having negative effects are negligible if the supplement is taken in small doses. According to users, higher doses cause significant irritation and anxiety that lasts for several days.

Problems may also arise if you attempt to enhance Unifiram's effects by combining it with stimulants such as alcohol or caffeine. People who used it in conjunction with caffeine potentiators, for example, reported unpleasant side effects.

To be safe, avoid using this without first consulting your doctor. You should also avoid using the supplement if you are taking prescription medication. It is impossible to predict how the supplement will interact with specific prescriptions because there have been no human trials.

Unifiram Reviews & Experiences Shared on Reddit

Here’s feedback from Redditors after trying this compound:

According to killword-noot:

“The most noticeable effect I noticed (and that others have reported) is reduction of fatigue, particularly while sleep-deprived--not in a stimulating way, just a reduced need for sleep and a feeling of wakefulness. It also seems to give a good boost to logical and mathematical reasoning similar to (but possibly better than) sunifiram…”

According to Sherlockian_Holmes:

“My experiences with unifiram have been quite astounding. It's a subtly stimulating compound that, unlike sunifiram, is not pushy in any way. I've been using 30 mg twice daily, and I find it to be incredibly helpful in overall motivation and cognitive clearness.”

What are the Best Unifiram Stacks?

Because there has been little research on Unifiram, it is difficult to predict which supplements will work well with it. However, because it is comparable to members of the Racetam family, stacking it with Racetams such as Piracetam or Phenylpiracetam should be beneficial. Noopept could be another option.

Where to Buy Unifiram?

Unifiram can be legally purchased in the United States. However, because the drug is unregulated, it's best to buy it from a vendor who has a track record of selling safe and effective nootropics.

Chemyo is a reputable supplier that provides high-quality nootropics at reasonable prices, based on our experience and positive feedback from buyers.


While there isn't much information available about the benefits and effectiveness of Unifiram, user feedback is encouraging. You should be able to enjoy its brain-boosting nootropic effects as long as you use it cyclically and do not exceed the recommended dose of 5-10 mg.


1“Unifiram.” National Center for Biotechnology Information. PubChem Compound Database, U.S. National Library of Medicine, https://pubchem.ncbi.nlm.nih.gov/compound/9861054.
2Scapecchi, Serena, et al. “Structure–Activity Relationship Studies on UNIFIRAM (DM232) and Sunifiram (DM235), Two Novel and Potent Cognition Enhancing Drugs.” Bioorganic & Medicinal Chemistry, Pergamon, 19 Nov. 2003, https://www.sciencedirect.com/science/article/abs/pii/S0968089603007120.