Unifiram Review: Benefits, Side Effects, Dosage & Where to Buy

Unifiram is one of the newer nootropic drugs.

It’s already making waves as a potent brain performance enhancer, but is it safe, and should you give it a try?

Let’s find out.

What Is Unifiram?

unifiram structure

Unifiram (DM-232) [R] is a potent nootropic that’s not approved in the U.S. for any medical use. That’s because there are no human studies regarding its effects or safety. Despite this, many people are using it as a cognitive enhancer and much more [R].

Compared to other nootropics, this is far more potent. For example, even though the supplement’s chemical structure is similar to that of Piracetam, a member of the Racetam family, it is far more potent. That means a far smaller dose of Unifiram is enough to deliver the same effects as a larger dose of Piracetam.

Like Piracetam, it works by interacting with AMPA receptors in the brain. Its influence on the AMPA receptors leads to increasing the brain’s glutamate uptake, which in turn causes heightened synaptic transmission between neurons. The result is enhanced mental performance.

Aside from this, it also triggers acetylcholine production, which in turn boosts general cognition and learning ability.

Effects & Benefits

The lack of human studies concerning its effects means there isn’t much information about its impact on the human brain. Nonetheless, people keep experimenting with it and have seen good results.

Many anecdotal reports indicate that using this improves concentration, memory, learning, mental energy, and basic cognition. These are the same results you can get from using popular Racetams like Sunifiram, Piracetam, and Aniracetam. The difference is Unifiram appears to be far more potent, delivering bigger results with smaller doses.

Based on the little available evidence, it seems to increase glutamate and acetylcholine levels in the brain. Higher levels of these brain chemicals lead to brain neurons that transmit signals between one another more effectively.

The result is an increase in your ability to process information faster and more clearly. That’s why it has become a fan favorite for anti-amnesiac effects, such as boosting attention span and mental acuity, and much more.

But unlike many Racetam nootropics, users of this compound claim it’s not as effective as a mood enhancer for anxiety or depression treatment. There’s also no evidence that it can boost physical performance.

That said, if you need a nootropic that boosts cognitive clarity, concentration, speed of thought, and confidence, anecdotal evidence indicates that it works.


Even though the FDA does not approve it, you can legally buy Unifiram in powder form or as capsules. The powder can be taken orally or sublingually for quicker effect.

But because the drug is unregulated and there are no human studies, there’s no official guideline regarding proper Unifiram dosage. According to anecdotal reports, due to the supplement’s potency, a 5-10 milligram (mg) dose is enough to experience strong effects. Many users also advise never going above 30 mg.

At higher doses, people report experiencing undesired effects, such as out-of-control experiences and long comedowns. Avoid such experiences by sticking with a dose that doesn’t exceed 10 mg. And if you are worried about building a tolerance, use the supplement cyclically instead of continuously.

Side Effects

The lack of human studies makes it difficult to determine if it has any side effects and what they are – if there are any.

According to anecdotal reports, as long as you use the supplement in low doses, the chances of experiencing side effects are minimal. People who have used it in higher doses report experiencing extreme irritability and anxiety that lasts for several days.

Problems may also arise if you try amplifying the effects of Unifiram by using it alongside stimulants, such as alcohol or caffeine. For example, people who used it with caffeine potentiates report experiencing unpleasant effects.

To be on the safe side, do not use this without first consulting your doctor. Also, if you are on prescribed medication, it’s best to avoid using the supplement. That’s because the lack of research means there’s no way of telling how the supplement will interact with certain medications.

Experiences Shared on Reddit

Here’s feedback from Redditors after trying this compound:

According to killword-noot:

“The most noticeable effect I noticed (and that others have reported) is reduction of fatigue, particularly while sleep-deprived–not in a stimulating way, just a reduced need for sleep and a feeling of wakefulness. It also seems to give a good boost to logical and mathematical reasoning similar to (but possibly better than) sunifiram…”

According to Sherlockian_Holmes:

“My experiences with unifiram have been quite astounding. It’s a subtly stimulating compound that, unlike sunifiram, is not pushy in any way. I’ve been using 30 mg twice daily, and I find it to be incredibly helpful in overall motivation and cognitive clearness.”

Unifiram Stacks

Due to the lack of data regarding Unifiram, it’s hard to tell what supplements will stack nicely with it. However, since it shares similarities with members of the Racetam family, stacking it with Racetams like Piracetam or Noopept should yield positive results.

Where to Buy Unifiram?

You can legally buy Unifiram in the U.S. But, because the drug is unregulated, it’s best to buy it from a vendor with a track record for selling safe and effective nootropics. Based on our experience and positive feedback from buyers, Science.bio is a reputable supplier that delivers top-quality nootropics at competitive prices


While there isn’t a lot of information regarding the benefits and effectiveness of Unifiram, the feedback from users who’ve tried it is promising.

As long as you use it cyclically and without exceeding the recommended dose of 5-10 mg, you should enjoy its brain-boosting nootropic effects without any significant side effects.