8 Best Nootropics for Longevity in 2023 (Tested & Reviewed)

Updated on January 16, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Are you looking to stay sharp and focused well into your later years? 

Whether you’re an aging professional, a student studying for exams, or just someone who wants to maintain their mental clarity, nootropics can help. 

In this article, we’ll explore the best nootropics for longevity and how they can help you keep your mind sharp as you age.

1. Mind Lab Pro

Mind Lab Pro is a nootropic stack that is tailored towards optimizing cognitive performance and supporting overall wellbeing. It contains 11 natural ingredients, including phosphatidylserine[1], bacopa monnieri[2], L-Tyrosine and Lion’s Mane mushroom extract. All of these ingredients have been studied for their potential to increase longevity. 

By stimulating the production of neurotransmitters like acetylcholine, Mind Lab Pro helps to improve memory, focus, and overall mental clarity. In addition, the ingredients in this nootropic stack have been linked to improved mood and stress management, which can help to reduce the risk of age-related diseases.

2. Creatine

Creatine is one of the most popular nootropics used to support long-term brain health and longevity. It is an amino acid derivative that helps to produce energy in the body and increases the number of mitochondria in cells. It has been shown to improve focus, mental clarity, and concentration. 

Additionally, creatine has anti-aging effects, which can help to protect against age-related cognitive decline. It also helps to reduce fatigue, enhance mood, and improve physical performance. It is important to note that creatine is best taken with food for optimal absorption and should be taken for at least two weeks for best results.

3. Ashwagandha

Ashwagandha is an herb that has been used for centuries in India for its health benefits. It helps reduce stress and anxiety, which are both linked to increased longevity. Studies have also shown that Ashwagandha can improve cognitive function and increase energy levels. 

It is often taken as a supplement, and is available in capsule, powder and extract form. As with any supplement, it is important to consult with your doctor before taking Ashwagandha, as it can interact with certain medications.

4. Alpha GPC

Alpha GPC is an excellent nootropic for longevity. It is one of the most studied nootropics and has been shown to improve cognitive performance, reduce stress and fatigue, and improve overall brain health. It has also been shown to increase levels of acetylcholine in the brain, which is essential for memory and learning. 

Alpha GPC can also be used to protect neurons from damage, reducing the risk of age-related cognitive decline. As such, it is a great supplement for those looking to maintain their cognitive abilities as they age.

5. Citicoline

Citicoline is another nootropic that has been studied for its effects on longevity. It is a natural supplement, derived from the lecithin found in egg yolks. It helps to regulate the release of acetylcholine, which is a neurotransmitter that plays a key role in memory and learning. 

Citicoline also helps to protect the brain from damage caused by free radicals. Studies have shown that it can improve cognitive function, focus, and memory. It can also help to reduce stress and fatigue, which can lead to better overall health and a longer life.

6. L-Theanine

L-Theanine is another one of the best nootropics for longevity. It is an amino acid found in green and black teas. It helps to reduce stress and anxiety, while improving cognitive performance. It is also known to help protect against age-related cognitive decline. 

L-Theanine helps to support healthy brain function and can help to protect against the damage caused by free radicals. It is also believed to promote relaxation and restful sleep. L-Theanine can be taken as a supplement or enjoyed from natural sources such as green tea or black tea.

7. Ginkgo Biloba

Ginkgo biloba is a natural nootropic that has been used for centuries to improve cognitive functioning and mental clarity. Its leaves contain a range of active compounds, including flavonoids and terpenoids, which are believed to be responsible for its effects. In addition, Ginkgo biloba is also believed to promote longevity[3] by reducing inflammation and oxidative stress in the body. 

Studies suggest that Ginkgo biloba may help to reduce the risk of Alzheimer’s disease, enhance memory, and improve blood circulation. It is also a powerful antioxidant, which can help protect cells against damage from free radicals. For these reasons, it is a popular choice among those looking to increase longevity through nootropics.

8. Bacopa Monnieri

Bacopa monnieri is another nootropic known for its cognitive benefits, but it also has potential to boost longevity. This herb has been used in traditional Ayurvedic medicine for centuries and is known for its anti-aging effects. It is believed to improve memory, concentration, alertness and focus. 

Additionally, it may reduce inflammation, protect the brain from toxins, and help protect against the damage caused by free radicals. Studies have found that Bacopa monnieri can help protect the brain from age-related cognitive decline, making it an important part of any longevity regimen.

How Can Nootropics Help With Longevity?

Nootropics can be beneficial for longevity. They can provide the brain and nerves with essential nutrients and specific neurotransmitter enhancement, which can help to defend against neurodegeneration and cognitive decline.

Nootropics, such as Creatine, Ashwagandha, Alpha GPC and Citicoline, can help promote longevity. Alpha GPC easily crosses the blood-brain barrier and can help improve cognitive functions. Ashwagandha helps alleviate stress, fatigue and restore energy. Creatine can help maintain muscle mass and provide energy. All of these nootropics can improve physical and mental health, thereby aiding in longevity.

The Benefits of Nootropics for Longevity

Nootropics are becoming increasingly popular as a way to promote longevity. They offer a variety of benefits that can help protect the brain and promote healthy aging. Nootropics can help improve cognitive function, prevent cognitive decline, and increase energy levels. They may also promote better sleep, reduce stress and anxiety, and support the immune system. 

Nootropics may also have anti-inflammatory effects, which could help protect the body from age-related diseases. There are also medications that address cognition and inattention. But they often come with side effects and addiction risks. So, nootropics can be a safer alternative as they help the brain to react and protect itself against stress without sedation or loss of skill.

The Safety and Side Effects of Taking Nootropics to Have Longevity

Nootropics are generally regarded as safe when taken in moderation, but they may have some side effects and interactions with certain medications. It is always important to be mindful of the ingredients in any supplement you take. 

the best nootropics for longevity

Some possible side effects to consider include headaches, stomach upset, diarrhea, irritability, and insomnia. Additionally, some nootropics, such as alpha GPC, can interact with anticoagulants and other drugs. It is important to consult your doctor if you are taking any medications before starting a nootropic routine for longevity.

Tips on Choosing the Right Nootropic for Longevity

When choosing a nootropic for longevity, it is important to consider the potential risks and side effects associated with each product. Additionally, ensure that the product is manufactured in a certified laboratory, and that it has a money-back guarantee. It is also important to check the ingredients and dosage recommendations to ensure that they are safe and effective. 

Finally, consider the cost of the product when comparing different nootropics, as some may be more expensive than others. By taking all of these factors into account, you can make an informed decision about which nootropic will be the best choice for you.

Conclusion: The Pros and Cons of Taking Nootropics for Longevity

In conclusion, the use of nootropics for longevity appears to be a promising option. Nootropics have been shown to improve cognitive abilities, mood, and energy levels, which can lead to a healthier and longer life. They also act as an antioxidant and may help to protect against age-related diseases. 

While there are some potential side effects associated with taking these supplements, they can be managed with proper use and research. When considering the use of nootropics for longevity, it is important to first consult with a medical professional to ensure they are safe and effective for you.


1Kim BK, Park SK. Phosphatidylserine modulates response to oxidative stress through hormesis and increases lifespan via DAF-16 in Caenorhabditis elegans. Biogerontology. 2020 Apr;21(2):231-244. doi: 10.1007/s10522-020-09856-0. Epub 2020 Jan 8. PMID: 31915963.
2Phulara SC, Shukla V, Tiwari S, Pandey R. Bacopa monnieri promotes longevity in Caenorhabditis elegans under stress conditions. Pharmacogn Mag. 2015 Apr-Jun;11(42):410-6. doi: 10.4103/0973-1296.153097. PMID: 25829783; PMCID: PMC4378142.
3Winter JC. The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat. Physiol Behav. 1998 Feb 1;63(3):425-33. doi: 10.1016/s0031-9384(97)00464-2. PMID: 9469738.