Noopept Megadose: In-Depth Guide & Risks

Updated on September 28, 2022
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

I guess you’ll agree that taking a supplement many times the usual dose will either give you the extra desired result or an unpleasant effect.

Well, let’s look at the brighter side.

What if a megadose of Noopept nootropic allows you to experience certain benefits?

A Noopept megadose can elevate your cognitive functions and recreational experience.

Read on to know more about the mega dose in this nootropic and what you may experience.

What is Noopept and How Does it Work?

Noopept, as its commercial name, is the N-phenylacetyl-L-prolylglycine ethyl ester drug that is one of the popular nootropics similar to Piracetam.

noopept omberacetam structure

Piracetam also enhances memory and is widely used for cognitive functions. Unlike Piracetam, Noopept has a less psychostimulatory effect.

Users even claim that among these two nootropics, Noopept is 1000x better than Piracetam.

An apparent differentiation from the user’s perspective between Noopept and Piracetam is the amount of dose for the effects to show.

Noopept is recommended to use in 10 mg to 30 mg daily, which is less than 10% of Piracetam dosages that are higher in grams amounting to 3 to 4 grams per day.

Moreover, Noopept positively alters a person's mental state with a variety of cognitive advantages. It acts as a brain booster after supplementation.

noopept megadose featured image

After taking Noopept nootropic, users experience an enhanced mood, focus, memory, learning, and energy levels.

This nootropic is a prodrug of cycloprolylglycine in which it positively affects neurotransmitter systems.

It refines communication between neurons in the brain and stimulates signal transmissions that unite thought processes and focus.

Consuming a reasonable Noopept dosage activates neurotransmitters such as serotonin (natural mood stabilizer), dopamine (chemical messenger for feel-good feelings), and glutamate (signals cognitive learning and memory).

It also amplifies another neurotransmitter, which is norepinephrine, a stress hormone that mobilizes the brain to act and improves attentiveness and energy.

Noopept is widely used by students, professors, athletes, and corporate professionals to boost their brainpower.

Using a Noopept Megadose

As Noopept dosing varies from person to person, it goes for how it performs in different users at high dosages or as part of Noopept stacks.

Research shows that taking nootropics like noopept pills in mega dose has not been recorded to result in extreme side effects.

using a noopept megadose

Unlike many other nootropics, a Noopept daily recommended dosage is as low as 10 to 30mg, which most consumers use one day a week.

This minimum dosage allows an individual to already feel the effects of enhanced cognition and being generally well.

When people start to realize that 10mg capsules are no longer enough or less effective for them, that’s the only time they begin to use noopept in mega dose.

However, it is not recommended for first-timers to immediately start using noopept in high doses. It is always necessary to assess your tolerance for this nootropic at lower dosages.

You may try the minimum dosage for two weeks first for optimizing your cognitive functions and if you want to give a megadose of Noopept a try, make sure to consult a doctor and do some additional research.

Once you’re good to go, you may try megadosing up to 100mg of Noopept twice a day to improve your senses, mood, and general cognition.

Mega Dose Benefits and Effects

The main benefit of Noopept nootropic allows one to use higher-order thinking. Literature and accounts concerning its megadose have no adverse effects.

mega dose benefits effects

In general, the following are Noopept’s megadose effects:

  • Improved learning ability,
  • Enhanced overall cognitive functions,
  • Improved memory and focus,
  • Promoted positive mood,
  • Enhanced reflexes and perception.

Like any other supplement, your results may not be the same as the others. Nootropics are personalized smart drugs, and not all of us have the same sensitivity level.

The following are the detailed areas with greater improvement using megadosing in Noopept nootropic:

  • Intelligence (analytical and computational reasoning)
  • Drive and motivation (self-confidence and energy levels)
  • Thoughts expression and verbal fluency
  • Creative thinking
  • Focus and concentration
  • Visual perception (colors and distinct features)
  • Stress and anxiety, especially in social settings
  • Negative thoughts and depression symptoms
  • Comprehension of philosophical matters
  • Music emotional reaction

Meanwhile, it’s best to know the possible side effects if you like to increase your Noopept intake.

Possible Side Effects

Nootropics such as Noopept are considered non-toxic, unlike Piracetam nootropic, which triggers dry mouth, sleep disruption, dizziness, diarrhea, headache, anxiety, and weight gain.

If Noopept is taken larger than the typical dosage, the following risks may increase, although no harmful results were reported.

  • Brain fog at dosages more than 100 mg daily
  • Decrease in short-term memory
  • Nausea and headaches
  • Emotional numbness
  • Feeling emotionally and mentally drained after usage
  • Effectiveness limitation due to increase tolerance for a higher dose

It is best to carefully consider the long list of benefits and the possible risks in using Noopept nootropic with these all.

Mega Dose Experiences Shared on Reddit

To give you more ideas on the possible things you might experience, here are the accounts or stories from the community of Noopept users on Reddit.

Users claimed that when they’ve increased their Noopept consumption, they’ve felt the urge to do some work.

Many shared similar stories that they were quite alert the whole time and were surprised how their work became pretty easy.

Here are what they have more to say.

According to LooksDelicious:

“I feel much muuuuuch better than I did yesterday and have completely returned to my normal self. Upon waking up this morning, I felt like complete crap as if I had 10+ alcoholic beverages. I'm hoping someone else has a better experience with high-dose Noopept than I have… I do not recommend doing what I did.”

According to tackybastard:

“I have found a megadose (150mg to 200mg) to be very stimulating in a clean, relaxing way. Like a next-day LSD experience, where things just feel different and positive.”

According to TheCrawlingKingSnake:

“Dude this is crazy. I decided today as well to try a megadose regimen with the year-old Noopept I have. I found the old bag from a year ago and decided what the hell. I made a bunch of 50-70mg capsules and took one, and went to work. I feel like I got some more energy and maybe talking a little smoother, but it could be a placebo effect.”

Frequently Asked Questions (FAQ)

Now that benefits, effects, and possible experiences were laid out, the following are the amount and duration of utilizing Nooppet in larger quantities.

How Much Noopept to Take?

Megadosing Noopept can range between 100mg to 200mg. Some swear to have used as much as 300mg taken three times a day, but this is relatively high and could be harmful to you.

Start with the base amount and slowly increase consumption per day until you have identified your preferred tolerance level.

For most, megadosing Noopept up to 100mg twice a day can already feel the desired outcome.

Research shows that to cause an overdose, Noopept has to be used to nearly 20 to 50 times the recommended portion.

Based on Reddit stories, it’s not recommended to have a mega dose regularly since its effectiveness will diminish in the long term.

Since Noopept is water-soluble, you may take it sublingually by placing it below your tongue to dissolve, just simply drink it along with water, or using Noopept nasal spray.

How Long Can I Take Noopept?

Most cycle the use of Noopept and recommends having weekend breaks. They claim it to be efficient when used for five days straight and a temporary off for two days.

Also, one week off every month guarantee that its efficacy will diminish.

A mega dose is considered ideal when used only per week for a maximum of one day.

These usage practices are discouraged unless you have consulted a doctor or a medical professional before a mega-dose consumption.


Nootropics, like Noopept, is potent and proven to be helpful. Things to be guaranteed are its significant benefits to most of its users, such as improved cognitive functions, mood, and well-being.

Although there is a long list of irresistible benefits of megadosing Noopept, throwing caution to the wind might not be favorable in the long run.

Risks are present, and it varies for every individual. That’s why it is advisable to always seek professional medical help before consuming mega dosages of Noopept.

As one can never be prepared for the side effects, if there are any, it is better to do extreme research on possible experiences that will be helpful in your Noopept encounter.

Also, considering the cost must be kept in mind. Searching for the best brand of Noopept will have a significant effect on your wallet and experience.