Noopept Megadose: In-Depth Guide & Risks

Updated on May 2, 2023
 by — reviewed by Jason Williams, PhD (Contributor: George Collins / Editor: Yoko Hill)

Noopept (GVS-111) is a powerful nootropic supplement that is gaining popularity in the world of cognitive enhancement.

It has been shown to improve memory, focus, and alertness. Some people have even gone so far as to take a megadose of Noopept, which means they take more than the recommended dosage.

But is a megadose safe, and is it really that effective?

Let’s take a look at what you need to know before taking a megadose of Noopept.

Using a Noopept Megadose

Noopept is a nootropic compound that has been observed to have cognitive-enhancing effects. It works by increasing neuron receptor sensitivity and increasing the availability of Glutamate and Acetylcholine (two essential neurotransmitters) in the brain (1).

using a noopept megadose

This makes it easier for users to focus, be productive and stay alert for long periods. As such, it’s commonly used as a nootropic supplement to improve mental performance. Anecdotal reports from people in the biohacking community suggest that when Noopept is taken at higher doses, known as ‘megadoses,’ it can produce even more impressive results.

Not only this, but some users also report experiencing better emotional regulation and greater mental clarity when taking higher doses of Noopept.

It's hypothesized that when compared with lower doses, megadoses are believed to offer superior results due to the increased binding affinity on receptor sites associated with increased productivity and alertness.

What's more, taking a Noopept megadose may also reduce fatigue levels associated with mental stress while helping individuals remain focused and attentive for extended periods.

That said, Noopept dosing varies from person to person; it goes for how it performs in different users at high dosages or as part of Noopept stacks (but more on this later).

Noopept Mega Dose Benefits and Effects

Megadosing Noopept can range between 100 mg to 200 mg. Some swear to have taken as much as 300 mg thrice a day, but this is relatively high and could harm you. Start with the base amount and slowly increase daily consumption until you have identified your preferred tolerance level. For most, megadosing Noopept up to 100 mg twice daily is enough.

At its core, Noopept acts as an effective neuroprotective agent by increasing nerve impulse transmissions in the brain and helping protect brain cells from age-related degeneration. This makes it an ideal choice for individuals seeking anti-aging effects or wishing to preserve their current cognitive function as they age.

In preclinical studies, Noopept also displayed antioxidant activity, which suggests that it helps decrease damage to cells caused by free radicals or other environmental factors (2).

mega dose benefits effects

In general, the following are Noopept’s megadose effects:

  • Increased acetylcholine (ACh) signaling
  • Increased expression of BDNF and NGF
  • Protects against glutamate toxicity
  • Increased inhibitory neurotransmission in the brain
  • Helps prevent memory and cognitive decline

Noopept Megadose Side Effects

Megadosing Noopept can result in mild to moderate side effects. The most common side effects are:

  • Headaches
  • Fatigue
  • Dizziness
  • Nausea
  • Insomnia
  • Loss of appetite

Rarely, some users may experience increased anxiety and irritability. Other less common side effects include gastrointestinal discomforts such as bloating, constipation, or diarrhea.

Some people have also reported muscle spasms or twitching while using this supplement. Additionally, people taking a Noopept megadose may experience decreased short-term memory and difficulty concentrating.

In some cases, users may also feel a tingling sensation in their extremities or experience dry mouth.

Noopept Megadose Experiences Shared on Reddit

To give you more ideas on the possible things you might experience, here are the accounts or stories from the community of Noopept users on Reddit.

According to LooksDelicious:

“I feel much muuuuuch better than I did yesterday and have completely returned to my normal self. Upon waking up this morning, I felt like complete crap as if I had 10+ alcoholic beverages. I'm hoping someone else has a better experience with high-dose Noopept than I have… I do not recommend doing what I did.”

According to tackybastard:

“I have found a megadose (150mg to 200mg) to be very stimulating in a clean, relaxing way. Like a next-day LSD experience, where things just feel different and positive.”

According to TheCrawlingKingSnake:

“Dude this is crazy. I decided today as well to try a megadose regimen with the year-old Noopept I have. I found the old bag from a year ago and decided what the hell. I made a bunch of 50-70mg capsules and took one, and went to work. I feel like I got some more energy and maybe talking a little smoother, but it could be a placebo effect.”

Frequently Asked Questions (FAQ)

The most frequently asked questions about Noopept megadosing are answered below:

What Are the Contraindications of Noopept?

Noopept can interact with certain medications, including but not limited to anticonvulsants and MAO inhibitors. It is also contraindicated for pregnant or breastfeeding women. People with gastrointestinal problems, kidney diseases, and liver diseases should avoid taking noopept.

How Long Can I Take Noopept?

People take 10-30 mg of Noopept per day for cognition. Usually, Noopept is cycled on and off, taking it for a few months and then taking a break for a few weeks. Megadosing Noopept should only be done for a short period of time - usually 1-2 weeks.

What Are the Long-Term Side Effects of Megadosing Noopept?

There are no long-term, large-scale studies on the effects of megadosing Noopept. There is anecdotal evidence, however, that suggests that megadosing noopept at 200 mg twice a day can lead to tolerance and reduced effectiveness over time.

Can Megadosing Noopept Cause Addiction?

There are no reported cases of addiction related to taking Noopept. However, when megadosing Noopept, it is possible to build up a tolerance to the effects. This means that users may need to increase their dosage or take more frequent doses to achieve the same effect as before.


Nootropics, like Noopept, are potent and proven to be helpful. Things to be guaranteed are its significant benefits to most of its users, such as improved cognitive functions, mood, and well-being.

Noopept has become increasingly popular due to its impressive range of cognitive and memory-boosting benefits. However, caution should be taken when considering megadosing. People have different reactions, so speaking with a medical professional is advised before taking Noopept.